权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

EFFECTS OF WEIGHT BEARING EXERCISE ON PEOPLE WITH DIABETES AND NEUROPATHIC FEET

负重运动对糖尿病和神经病足患者的影响

基本信息

批准号：
7840414
负责人：
MICHAEL J MUELLER
金额：
$ 18.81万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-12 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7840414
关键词：
Adult American Ankle Articular Range of Motion Beck depression inventory Body Composition Body mass index Communities Complications of Diabetes Mellitus Control Groups Controlled Clinical Trials Data Diabetes Mellitus Dual-Energy X-Ray Absorptiometry Equilibrium Exercise Exposure to Flexor Foot Injuries Functional disorder Glycosylated hemoglobin A Goals Guidelines Impairment Incidence Injury Knowledge Leg Lesion Lipids Lower Extremity Magnetic Resonance Imaging Measures Muscle Muscle Weakness Neuropathy Outcome Patients Peripheral Nervous System Diseases Physical activity Randomized Recording of previous events Research Risk Serum Skin Sports Medicine Stress Surface Symptoms Temperature Testing Torque Ulcer Walking Weight-Bearing state ankle joint college digital disability foot functional disability high risk improved muscle strength performance tests pressure programs prospective public health relevance

项目摘要

DESCRIPTION (provided by applicant): People with diabetes and peripheral neuropathy (DM+PN) have substantial lower extremity impairments, functional limitations and disability. In addition to muscle weakness and poor balance, they also are at high risk for foot ulcerations, especially if they have a history of ulceration. Exercise is an important treatment component to help control the complications of diabetes. The American Diabetes Association and the American College of Sports Medicine recommend that adults with DM participate in at least 30 minutes a day of moderate-intensity physical activity that is consistent with a brisk walk. However, these groups discourage weight-bearing exercise for people with DM+PN due to risk of exercise-induced foot injury. Little data exists on the effect of exercise on people with DM+PN and no data support the restriction to limit weight bearing exercise in those with DM+PN. The Primary Goal of this proposal is to conduct a pilot randomized prospective controlled clinical trial to determine if people with DM+PN can benefit from a progressive weight-bearing exercise program (compared to a non weight bearing exercise program and a non exercising control group) without an increase in skin breakdown or foot lesions. Outcomes are included from measures of pathophysiology, impairments, functional limitations, and disability. The results of this study will help to determine if neuropathic skin and muscle can adapt to increasing physical stress levels without injury, and could have important implications for weight- bearing and exercise guidelines for people with DM+PN. PUBLIC HEALTH RELEVANCE: People with diabetes and peripheral neuropathy have substantial problems with weakness, stiffness, and insensitivity in their legs that result in problems with skin breakdown, balance, functional mobility (walking and stair climbing) and participation in community activities. Exercise has been shown to help these mobility problems in people with diabetes, but has not been tested in people who also have peripheral neuropathy. The Primary Goal of this proposal is to conduct a pilot randomized prospective controlled clinical trial to determine if people with diabetes and peripheral neuropathy can benefit from a progressive weight-bearing exercise program without an increase in skin breakdown or foot lesions. The benefits of a weight bearing exercise program will be compared to the benefits of a non weight bearing exercise program and a non exercising control group. The results of this study would have important implications for weight-bearing and exercise guidelines for people with diabetes and peripheral neuropathy.

描述（由申请人提供）：糖尿病和周围神经病变（DM+PN）患者有严重的下肢损伤、功能限制和残疾。除了肌肉无力和平衡差，他们也有患足部溃疡的高风险，特别是如果他们有溃疡史。运动是帮助控制糖尿病并发症的重要治疗组成部分。美国糖尿病协会和美国运动医学院建议糖尿病患者每天至少参加30分钟的中等强度的体力活动，这与快走一致。然而，由于存在运动性足部损伤的风险，这些人群不鼓励DM+PN患者进行负重运动。关于运动对DM+PN患者的影响的数据很少，也没有数据支持限制DM+PN患者的负重运动。本提案的主要目的是进行一项初步随机前瞻性对照临床试验，以确定DM+PN患者是否可以从渐进式负重运动计划中获益（与非负重运动计划和非运动对照组相比），而不会增加皮肤破裂或足部病变。结果包括从病理生理学，损伤，功能限制和残疾的措施。这项研究的结果将有助于确定神经性皮肤和肌肉是否可以在不受伤的情况下适应不断增加的身体压力水平，并可能对DM+PN患者的负重和运动指南产生重要影响。公共卫生相关性：患有糖尿病和周围神经病变的人具有腿部虚弱、僵硬和不敏感的实质性问题，这导致皮肤破裂、平衡、功能性移动（行走和爬楼梯）和参与社群活动的问题。运动已被证明有助于糖尿病患者的这些活动问题，但尚未在患有周围神经病变的人中进行测试。该提案的主要目标是进行一项试点随机前瞻性对照临床试验，以确定糖尿病和周围神经病变患者是否可以从渐进式负重运动计划中获益，而不会增加皮肤破裂或足部病变。将比较负重锻炼计划的获益与非负重锻炼计划和非锻炼对照组的获益。这项研究的结果将对糖尿病和周围神经病变患者的负重和运动指南产生重要影响。