Persisting Effects of Prenatal Anxiety on Child Outcomes

产前焦虑对儿童结局的持续影响

• 批准号: 7826574
• 负责人: Thomas G O'Connor
• 金额: $ 34.89万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7826574
• 关键词: 14 year old; Accounting; Address; Adolescent; Adult; Age; Ally; Animal Experimentation; Anxiety; Anxiety Disorders; Behavioral; Birth; Child; Cognitive; Communities; Data; Data Reporting; Development; Diagnostic; Dose; Emotional; Event; Exposure to; Genetic; Genetic Polymorphism; Genetic Risk; Glucocorticoid Receptor; Human; Individual; Individual Differences; Investigation; Life; Link; Long-Term Effects; Longitudinal Studies; Measures; Mediating; Mental Depression; Mental Health; Neurosecretory Systems; Outcome; Pattern; Persons; Platelet Factor 4; Pregnancy; Process; Psychopathology; Public Health; Receptor Gene; Research; Risk; Role; Sampling; Science; Stress; Testing; Variant; animal data; base; early adolescence; experience; human data; multidisciplinary; offspring; postnatal; prenatal; prenatal stress; prevent; programs; prospective; psychosocial; response; theories

DESCRIPTION (provided by applicant): Experimental animal research strongly implicates prenatal stress in the long-term behavioral/emotional, cognitive, and neuroendocrine disturbance in offspring in a manner suggesting a programming mechanism. Recently reported data suggest that a parallel association may exist for prenatal anxiety in humans. The potential implications of these findings for understanding and preventing mental health problems in children and adults are both obvious and substantial. Basic questions remain, however, about the persistence of effects in humans, the mechanisms underlying the association, and the role of postnatal environmental experiences and genetic factors in accounting for individual variation. This proposal addresses these questions in the context of a unique multidisciplinary prospective, longitudinal study of a large community sample that has been continuously followed since early pregnancy. The study proposes to conduct in-person assessments of approximately 8,000 14 year-olds who have been followed since birth and for whom exposure to prenatal maternal anxiety and postnatal psychosocial adversity has been well-characterized. Data on psychopathology and HPA axis functioning at age 14 will be predicted from the interplay between previously collected data on maternal anxiety in pregnancy, specific psychosocial risks, and polymorphisms for the glucocorticoid receptor genes. The current study would provide a state-of-the-science investigation of prenatal anxiety that will have substantial impact on developmental theory and public health, and build on and extend research into the genetic bases of individual differences in stress vulnerability and psychopathology Specific aims of this research are to a) examine the long-term effects of prenatal anxiety on dimensional and diagnostic measures of psychopathology in early adolescence; b) assess the role of the HPA axis underlying the links between prenatal anxiety on adolescent psychopathology and stress vulnerability; c) test competing hypotheses concerning the processes by which prenatal anxiety has direct, mediated or moderated effects on adolescent psychopathology; and d) test the hypothesis that the effects of prenatal anxiety/stress on behavioral/emotional problems in early adolescence are moderated by genetic risk.

描述（由申请人提供）：实验动物研究强有力地表明，产前应激在后代的长期行为/情绪、认知和神经内分泌紊乱中存在一种编程机制。最近报道的数据表明，人类产前焦虑可能存在类似的关联。这些发现对于理解和预防儿童和成人的心理健康问题的潜在影响是显而易见的。然而，基本的问题仍然存在，关于人类影响的持久性，关联的潜在机制，以及出生后环境经历和遗传因素在解释个体差异中的作用。该建议在一个独特的多学科前瞻性的背景下解决这些问题，纵向研究一个大的社区样本，自怀孕早期以来一直持续跟踪。该研究建议对大约8000名14岁的儿童进行面对面的评估，这些儿童自出生以来一直受到跟踪调查，他们在产前、产妇焦虑和产后心理逆境的暴露都有很好的特征。14岁时的精神病理和HPA轴功能数据将通过先前收集的孕妇孕期焦虑、特定社会心理风险和糖皮质激素受体基因多态性之间的相互作用来预测。目前的研究将提供对产前焦虑的最先进的科学调查，这将对发展理论和公共卫生产生重大影响，并建立和扩展对压力易感性和精神病理学个体差异的遗传基础的研究。本研究的具体目标是：a)检查产前焦虑对青春期早期精神病理学维度和诊断措施的长期影响；b)评估HPA轴在产前焦虑对青少年心理病理和应激易感性之间的作用；C)检验关于产前焦虑对青少年精神病理有直接、介导或缓和影响的过程的相互矛盾的假设；d)检验产前焦虑/压力对青春期早期行为/情绪问题的影响是由遗传风险调节的这一假设。

项目成果

Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3.

孕产妇产前抑郁症与印迹基因PEG3的胎盘表达降低有关。

• DOI: 10.1017/s0033291716001598
• 发表时间: 2016-10
• 期刊: PSYCHOLOGICAL MEDICINE
• 影响因子: 6.9
• 作者: Janssen, A. B.;Capron, L. E.;O'Donnell, K.;Tunster, S. J.;Ramchandani, P. G.;Heazell, A. E. P.;Glover, V.;John, R. M.
• 通讯作者: John, R. M.

In utero cortisol and testosterone exposure and fear reactivity in infancy.

• DOI: 10.1016/j.yhbeh.2009.12.012
• 发表时间: 2010-03
• 期刊: HORMONES AND BEHAVIOR
• 影响因子: 3.5
• 作者: Bergman, Kristin;Glover, Vivette;Sarkar, Pampa;Abbott, Dave H.;O'Connor, Thomas G.
• 通讯作者: O'Connor, Thomas G.

Cortisol awakening response and subsequent depression: prospective longitudinal study.

• DOI: 10.1192/bjp.bp.113.126250
• 发表时间: 2014-02
• 期刊: The British journal of psychiatry : the journal of mental science
• 作者: Carnegie R;Araya R;Ben-Shlomo Y;Glover V;O'Connor TG;O'Donnell KJ;Pearson R;Lewis G
• 通讯作者: Lewis G

Maternal prenatal cortisol and infant cognitive development: moderation by infant-mother attachment.

• DOI: 10.1016/j.biopsych.2010.01.002
• 发表时间: 2010-06-01
• 期刊: BIOLOGICAL PSYCHIATRY
• 影响因子: 10.6
• 作者: Bergman, Kristin;Sarkar, Pampa;Glover, Vivette;O'Connor, Thomas G.
• 通讯作者: O'Connor, Thomas G.

Locus of Control and Negative Cognitive Styles in Adolescence as Risk Factors for Depression Onset in Young Adulthood: Findings From a Prospective Birth Cohort Study.

• DOI: 10.3389/fpsyg.2021.599240
• 发表时间: 2021
• 期刊: Frontiers in psychology
• 影响因子: 3.8
• 作者: Costantini I;Kwong ASF;Smith D;Lewcock M;Lawlor DA;Moran P;Tilling K;Golding J;Pearson RM
• 通讯作者: Pearson RM