Evidence-based multi level risk reduction for Bahamian mid-adolescents

巴哈马中青少年基于证据的多层次风险降低

• 批准号: 7884580
• 负责人: BONITA FRANCES STANTON
• 金额: $ 54.4万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7884580
• 关键词: 10 year old; AIDS prevention; AIDS/HIV problem; Abstinence; Acquired Immunodeficiency Syndrome; Address; Adolescence; Adolescent; Adolescent Risk Behavior; African; Age; Attention; Bahamas; Behavior; Behavior Control; Behavior Therapy; Behavioral; Caribbean region; Caring; Categories; Cells; Centers for Disease Control and Prevention (U.S.); Child; Clinical Trials Design; Collaborations; Color; Commit; Communication; Consent; Consultations; Country; Data; Decision Making; Developing Countries; Development; Diffusion; Education; Educational Curriculum; Effectiveness; Elements; Enrollment; Environment; Environmental Exposure; Epidemic; Epidemiology; Evaluation; Exhibits; Exposure to; Family health status; Funding; Future; Goals; Government; HIV; HIV Infections; Health Policy; Hour; Individual; Intention; Intervention; Knowledge; Learning; Letters; Life; Literature; Meta-Analysis; Motivation; Nature; Pan American Health Organization; Parents; Perception; Persons; Population; Positioning Attribute; Postdoctoral Fellow; Prevalence; Prevention; Prevention Research; Prevention program; Process; Publishing; Randomized; Randomized Controlled Trials; Recruitment Activity; Reporting; Research; Research Personnel; Resources; Risk; Risk Behaviors; Risk Reduction; Safe Sex; Sampling; Schedule; Schools; Students; Subgroup; Testing; Theoretical model; Time; Training; Transportation; Turks and Caicos Islands; UNESCO; Update; Work; Youth; base; career; cohort; condoms; design; effective intervention; elementary school; environmental intervention; evidence base; experience; follow-up; group intervention; high risk; high school; intervention effect; member; middle school; parental involvement; parental monitoring; parental role; post intervention; prevent; programs; protective behavior; public health relevance; response; sex; sex risk; sixth grade; skills; success; teacher; theories; therapy design; young adult

DESCRIPTION (provided by applicant): Over the last quarter century, substantial progress has been made in effecting purposeful behavioral change to reduce HIV/AIDS risk. Nevertheless, specific demographic and socio-geographic sub-groups remain at high risk and substantial challenges in maintaining purposeful behavioral change persist. Among those groups remaining at high risk are adolescents and young adults, persons of color, and individuals residing in transitional and developing countries. Challenges that have continued to confront behavioral risk reduction interventions include: a) waning intervention effects over time; b) changing environmental exposures and responses thereto that occur during adolescence; and c) the resource intensive nature of multiple session behavioral interventions especially in resource poor settings such as developing and transitional countries. This competitive renewal of R01MH069229 will focus on a particularly high risk population (youth of African descent attending Grade 10 in government high schools in The Bahamas, a nation with an HIV sero- prevalence of 3%) and proposes a four-cell, randomized, controlled trial designed to address each of the four challenges outlined above, building upon our ongoing research. During the past 4.5 years in our current funding period, the US-Bahamian research team has been evaluating the Bahamian adaptation of a 10- session adolescent HIV prevention program entitled "Focus on Youth in The Caribbean" (FOYC) and the 1- hour adapted parental monitoring intervention entitled "Caribbean Informed Parents and Children Together" (CImPACT) through a randomized, controlled three-celled trial involving 1360 Grade 6 youth and 1175 of their parents. Beginning at the 6 months follow-up and extending through 24 months follow-up, condom-use, condom-use intention, and relevant perceptions and knowledge were significantly higher among FOYC youth compared to control youth. Despite the efficacy of FOYC, the and 36 (preliminary data) actual rates among both FOYC and control youth are concerningly low (e.g. condom-use rates at 24 months and 36 months was 30% and 40% among FOYC youth and 20% and 25% among controls). Therefore, the Department of Education of The Bahamas and the US-Bahamian Research Team seek to identify an effective intervention that can be delivered to Grade 10 students in The Bahamas. In the research described in this submission, we propose to: a) Recruit 2600 youth (and their parents) from 172 Grade 10 FHLE classrooms over two years from all 7 government high schools in New Providence, The Bahamas; b) Randomly assign at the level of the classroom 2400 youth (and their parents) from 160 classes to one of four intervention conditions: 1) HFLE only (no parent intervention); 2) BFOOY only (no parent intervention); 3) BFOOY plus ImPACT (delivered to parent-youth dyads with a six month parent booster); or 4) BFOOY plus GFI (delivered to parent-youth dyads with a six month parent booster); c) Randomly assign one of the seven high schools (with ~12 HFLE classes and ~200 students) to a "control school" condition to explore possible class-to-class contamination within schools; d) Assess intervention effects on the entire sample at 6, 12, 18 and 24 months post-intervention (and among parents at 6 and 12 months); and e) Conduct sub-group analyses to explore: i) the impact of interventions received at two critical junctures during adolescence; ii) the effect of being part of a longitudinal trial on risk/protective behaviors; and iii) the extent of intervention contamination if the unit of randomization is the class rather than the school. PUBLIC HEALTH RELEVANCE: The proposed research will allow us to determine the best way to intervene with youth as they enter into the age of greatest HIV risk whether they have or have not had previous exposure to HIV risk reduction efforts. The project will help us to elucidate the role that parents may be able to assume in collaboration with a formal, school-based HIV prevention program to help protect their youth.. This research is both timely and of great global importance addressing many of the key research questions confronting AIDS researchers throughout the world. 1

描述（由申请人提供）：在过去的四分之一世纪中，在实现有目的的行为改变以降低艾滋病毒/艾滋病风险方面取得了实质性进展。然而，特定的人口和社会地理亚群体仍然处于高风险之中，在保持有目的的行为改变方面仍然存在重大挑战。在这些仍然处于高风险的群体中，有青少年和年轻人、有色人种以及居住在转型期国家和发展中国家的个人。减少行为风险干预措施继续面临的挑战包括：a）干预效果随时间减弱; B）青少年时期不断变化的环境暴露及其反应;以及c）多疗程行为干预措施的资源密集型性质，特别是在发展中国家和转型期国家等资源匮乏的环境中。R01MH 069229的竞争性更新将重点关注特别高风险人群（在巴哈马政府高中就读10年级的非洲裔青年，巴哈马的HIV血清流行率为3%），并提出了一项四细胞随机对照试验，旨在解决上述四个挑战中的每一个，建立在我们正在进行的研究基础上。在我们当前资助期的过去4.5年中，美国-巴哈马研究小组一直在评估巴哈马适应题为"关注加勒比地区青年"（FOYC）的10期青少年艾滋病毒预防计划和题为"加勒比地区知情父母和儿童一起"（CImPACT）的1小时适应性父母监测干预措施，对照三细胞试验，涉及1360名六年级青年和1175名他们的父母。从6个月的随访开始，一直到24个月的随访，FOYC青年的安全套使用、安全套使用意图以及相关的认知和知识显著高于对照青年。尽管FOYC有效，但FOYC和对照组青年的实际使用率（初步数据）令人担忧地低（例如，FOYC青年24个月和36个月时的安全套使用率分别为30%和40%，对照组为20%和25%）。因此，巴哈马教育部和美国-巴哈马研究小组寻求确定一种可向巴哈马十年级学生提供的有效干预措施。在本报告所述的研究中，我们建议：a）招募2600名青年在巴哈马新普罗维登斯的所有7所政府高中的172个10年级FHLE教室（及其家长）中进行为期两年的调查; B）在教室一级随机分配2400名青年（及其家长）从160个班级到四个干预条件之一：1）仅HFLE（无家长干预）; 2）仅BFOOY（无家长干预）; 3）BFOOY + ImPACT（提供给父母-青少年二人组，父母助推6个月）;或4）BFOOY加GFI（提供给父母-青年二人组，并有六个月的父母助推器）; c）随机分配七所高中之一（约12个HFLE班级和约200名学生）到"对照学校"条件，以探索学校内可能的班级间污染; d）评估干预后6、12、18和24个月对整个样本的干预效果（以及在6个月和12个月的父母中）;以及e）进行分组分析，以探讨：i）在青春期两个关键时刻接受的干预措施的影响; ii）作为纵向试验的一部分对风险/保护行为的影响; iii）如果随机化的单位是班级而不是学校，干预污染的程度。 公共卫生相关性：这项拟议的研究将使我们能够确定在青年进入艾滋病毒风险最高的年龄时进行干预的最佳方式，无论他们以前是否接触过降低艾滋病毒风险的努力。该项目将帮助我们阐明父母在与正式的、以学校为基础的艾滋病毒预防计划合作中可能能够承担的作用，以帮助保护他们的青少年。这项研究既及时又具有全球重要性，解决了世界各地艾滋病研究人员面临的许多关键研究问题。1