Childhood Overweight in the Heartwatch Cohort: A Pilot Follow-up Study

Heartwatch 队列中的童年超重：一项试点后续研究

• 批准号: 7937161
• 负责人: LAURA ANN COLEMAN
• 金额: $ 4.42万
• 依托单位: MARSHFIELD CLINIC RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7937161
• 关键词: Address; Adult; Advertising; Age; Ankle; Blood Pressure; Body Weight; Cardiovascular Diseases; Child; Childhood; Chronic; Clinic; Clinical; Computerized Medical Record; Conflict (Psychology); Continuity of Patient Care; Cross-Sectional Studies; Data; Disease; Epidemic; Family history of; Farming environment; Fasting; Follow-Up Studies; Foundations; Future; Gender; Goals; Health; Healthcare; Height; Hip region structure; Incidence; Inflammation; Inpatients; Intervention; Knowledge; Lipids; Lipoproteins; Longitudinal Studies; Measurement; Measures; Medical; Medical center; Methods; Newspapers; Obesity; Outcome; Outpatients; Overweight; Participant; Population; Questionnaires; Radio; Recruitment Activity; Reporting; Research; Resources; Risk; Risk Factors; Role; Rural; Rural Community; Sampling; Serum; Stable Populations; Staging; Television; Testing; Time; United States; Weight; Work; Youth; base; cardiovascular disorder risk; cohort; design; emerging adult; follow-up; high school; indexing; member; population based; pre-clinical; prevent; public health priorities; residence; young adult

DESCRIPTION (provided by applicant): We propose a pilot follow-up to the 1982 Heartwatch Study, a cross-sectional study in Marshfield, WI of cardiovascular disease (CVD) risk factors in 3106 children. Marshfield is unique in that it is an isolated, rural community, but with access to a single, major medical center, providing a rich body of data over time. Specific aims of this study are: 1) to demonstrate our ability to reassemble a cohort of the 1982 population. To accomplish this goal we will a) locate members of the original cohort; and b) describe the sub-group of participants in the follow-up cohort; and 2) to determine the relationship between childhood weight status per se and pre-clinical CVD during young adulthood among members of the Heartwatch cohort. To accomplish this goal we will test the hypothesis that childhood OW/at risk for OW per se is associated with increased incidence of pre-clinical CVD in young adults, independent of the effect of adult obesity on disease. To test this hypothesis we will conduct a clinical exam including measurement of height, weight, waist and hip circumference, BP, ankle- brachial index and fasting lipid and lipoprotein measurements. This RO3 will provide unique, longitudinal knowledge of the relationship between weight status and CVD risk, in childhood versus adulthood, in a well-characterized, established cohort. Furthermore, by confirming our ability to recruit a sub-group of the 1982 cohort and by providing preliminary data on the relationship between pre-clinical CVD and childhood weight status in this cohort, we will lay the foundation for future applications in which we will propose to study potential mechanisms, such as the role of obesity-induced inflammation, in contributing to the adverse health effects of childhood overweight. Ultimately, this information will help in designing targeted interventions to prevent childhood overweight and associated diseases. Obesity has become a national public health priority, reaching epidemic proportions among both adults and children. It is critically important to conduct studies aimed at 1) elucidating the health consequences of obesity and 2) understanding when these health effects begin to develop. The currently proposed study will address the issue of whether childhood overweight per se is associated with an increased incidence of pre-clinical cardiovascular disease among young adults, independent of the effect of adult obesity. Results from this study will set the stage for future research into the long-term health consequences of childhood overweight.

描述（由申请人提供）：我们建议对1982年Heartwatch研究进行试点随访，该研究是在威斯康星州Marshfield进行的一项横断面研究，涉及3106名儿童的心血管疾病（CVD）风险因素。马什菲尔德的独特之处在于它是一个孤立的农村社区，但可以访问一个单一的主要医疗中心，随着时间的推移提供了丰富的数据。这项研究的具体目的是：1）证明我们有能力重新组装1982年人口的队列。为了实现这一目标，我们将a）定位原始队列的成员;和B）描述随访队列中的受试者亚组;和2）确定Heartwatch队列成员中儿童期体重状态本身与青年期临床前CVD之间的关系。为了实现这一目标，我们将测试的假设，即儿童OW/OW本身的风险与临床前心血管疾病的发病率增加，在年轻的成年人，独立的成人肥胖对疾病的影响。为了验证这一假设，我们将进行临床检查，包括测量身高、体重、腰围和臀围、血压、踝臂指数和空腹血脂和脂蛋白测量。该RO 3将在一个特征明确的既定队列中提供关于儿童期与成年期体重状况与CVD风险之间关系的独特的纵向知识。此外，通过确认我们招募1982年队列的一个亚组的能力，并通过提供该队列中临床前CVD和儿童体重状况之间关系的初步数据，我们将为未来的应用奠定基础，我们将提出研究潜在的机制，如肥胖诱导的炎症，在促进儿童超重的不良健康影响中的作用。最终，这些信息将有助于设计有针对性的干预措施，以预防儿童超重和相关疾病。肥胖症已成为国家公共卫生的优先事项，在成人和儿童中已达到流行病的程度。进行旨在1）阐明肥胖的健康后果和2）了解这些健康影响何时开始发展的研究至关重要。目前拟议的研究将解决儿童超重本身是否与年轻人临床前心血管疾病发病率增加相关的问题，而不受成人肥胖的影响。这项研究的结果将为未来研究儿童超重的长期健康后果奠定基础。