Childhood Overweight in the Heartwatch Cohort: A Pilot Follow-up Study

描述（由申请人提供）：我们建议对1982年Heartwatch研究进行试点随访，该研究是在威斯康星州马什菲尔德进行的一项关于3106名儿童心血管疾病（CVD）危险因素的横断面研究。马什菲尔德的独特之处在于，它是一个孤立的农村社区，但它可以进入一个主要的医疗中心，随着时间的推移，它提供了丰富的数据。本研究的具体目的是：1)证明我们有能力重新组建1982年人口的队列。为了实现这一目标，我们将a)找到原始队列的成员；b)描述随访队列中参与者的亚组；2)确定心脏观察队列成员的童年体重状况本身与成年早期临床前心血管疾病之间的关系。为了实现这一目标，我们将检验儿童OW/ OW风险本身与年轻人临床前CVD发病率增加相关的假设，独立于成人肥胖对疾病的影响。为了验证这一假设，我们将进行临床检查，包括测量身高、体重、腰围和臀围、血压、踝肱指数和空腹脂质和脂蛋白测量。该RO3将在一个特征明确、已建立的队列中，为儿童与成年时期体重状况与心血管疾病风险之间的关系提供独特的纵向知识。此外，通过确认我们有能力招募1982年队列的一个亚组，并通过提供临床前心血管疾病与该队列中儿童体重状况之间关系的初步数据，我们将为未来的应用奠定基础，我们将提出研究潜在的机制，如肥胖诱导炎症的作用，在促进儿童超重的不良健康影响中。最终，这些信息将有助于设计有针对性的干预措施，以预防儿童超重和相关疾病。肥胖已成为国家公共卫生的重点问题，在成人和儿童中已达到流行病的程度。开展以下研究至关重要：1)阐明肥胖对健康的影响；2)了解这些健康影响何时开始形成。目前提出的研究将解决儿童超重本身是否与年轻人临床前心血管疾病发病率增加相关的问题，独立于成人肥胖的影响。这项研究的结果将为未来关于儿童超重对健康的长期影响的研究奠定基础。

DESCRIPTION (provided by applicant): We propose a pilot follow-up to the 1982 Heartwatch Study, a cross-sectional study in Marshfield, WI of cardiovascular disease (CVD) risk factors in 3106 children. Marshfield is unique in that it is an isolated, rural community, but with access to a single, major medical center, providing a rich body of data over time. Specific aims of this study are: 1) to demonstrate our ability to reassemble a cohort of the 1982 population. To accomplish this goal we will a) locate members of the original cohort; and b) describe the sub-group of participants in the follow-up cohort; and 2) to determine the relationship between childhood weight status per se and pre-clinical CVD during young adulthood among members of the Heartwatch cohort. To accomplish this goal we will test the hypothesis that childhood OW/at risk for OW per se is associated with increased incidence of pre-clinical CVD in young adults, independent of the effect of adult obesity on disease. To test this hypothesis we will conduct a clinical exam including measurement of height, weight, waist and hip circumference, BP, ankle- brachial index and fasting lipid and lipoprotein measurements. This RO3 will provide unique, longitudinal knowledge of the relationship between weight status and CVD risk, in childhood versus adulthood, in a well-characterized, established cohort. Furthermore, by confirming our ability to recruit a sub-group of the 1982 cohort and by providing preliminary data on the relationship between pre-clinical CVD and childhood weight status in this cohort, we will lay the foundation for future applications in which we will propose to study potential mechanisms, such as the role of obesity-induced inflammation, in contributing to the adverse health effects of childhood overweight. Ultimately, this information will help in designing targeted interventions to prevent childhood overweight and associated diseases. Obesity has become a national public health priority, reaching epidemic proportions among both adults and children. It is critically important to conduct studies aimed at 1) elucidating the health consequences of obesity and 2) understanding when these health effects begin to develop. The currently proposed study will address the issue of whether childhood overweight per se is associated with an increased incidence of pre-clinical cardiovascular disease among young adults, independent of the effect of adult obesity. Results from this study will set the stage for future research into the long-term health consequences of childhood overweight.