Mercury, Selenium and Risk of Cardiovascular Disease in Women and Men

汞、硒与女性和男性心血管疾病的风险

• 批准号: 7820009
• 负责人: DARIUSH MOZAFFARIAN
• 金额: $ 123.06万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-26 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7820009
• 关键词: Acceleration; Adult; Affect; Age; Alcohol consumption; Antioxidants; Benefits and Risks; Biological Assay; Biological Markers; Blood; Blood capillaries; Brain; Cardiovascular Diseases; Cardiovascular system; Chronic; Clip; Cohort Studies; Communities; Consumption; Coronary heart disease; Data; Decision Making; Development; Disease; Ensure; Environmental Exposure; Equipment; Evaluation; Event; Exposure to; Fishes; Food; Future; Gases; Geographic Locations; Geographic state; Gold; Health; Health Policy; Heavy Metals; Hour; Human Resources; Incidence; Individual; Intake; Joints; Linear Models; Manuscripts; Materials Testing; Measurement; Measures; Mercury; Methods; Methylmercury Compounds; Missouri; Modeling; Morbidity - disease rate; Multivitamin; Neutrons; Occupations; Omega-3 Fatty Acids; Outcome; Parents; Personnel Staffing; Physical activity; Play; Policies; Policy Maker; Population; Positioning Attribute; Postdoctoral Fellow; Preparation; Public Health; Quartz; Questionnaires; Recommendation; Relative (related person); Relative Risks; Reporting; Research; Risk; Risk Assessment; Risk Estimate; Risk-Benefit Assessment; Role; Sampling; Science; Scientist; Selection Bias; Selenium; Services; Shipping; Ships; Smoking; Source; Stroke; Structure of nail of toe; Survivors; System; Testing; Time; Toxic effect; Trace Elements; Tube; Vial device; Woman; Work; capillary; cardiovascular disorder risk; case control; cost; design; dietary trace element; evidence base; geographic difference; high risk; in utero; infancy; instrument; men; meter; mortality; novel; parent grant; prospective; protective effect; public health relevance; residence

DESCRIPTION (provided by applicant): Controversy exists among scientists, policy makers, and the public/media regarding health risks and benefits of fish intake in adults. Evidence indicates that long-chain n-3 fatty acids (n-3 FA) reduce risk of cardiovascular disease (CVD). Conversely, exposure to methylmercury (MeHg) present in some fish species may increase CVD risk. Fish are also a major source of selenium (Se), a trace element that may protect against MeHg toxicity. Thus, simultaneous consideration of CVD risks and benefits of n-3 FA, MeHg, and Se is necessary to allow informed decision-making by individuals and policy makers. Unfortunately, prior analyses of CVD effects of fish intake have generally focused either on risks of MeHg or benefits of n-3 FA (or, more rarely, of Se), rather than investigating their joint impact on CVD health. Accurate quantitative assessment of total effects of MeHg, Se, and n-3 FA would require comparable and objective biomarker assessments of each exposure in the same population, with adequate numbers of prospectively ascertained CVD endpoints and standardized covariate evaluation to minimize bias and imprecision. This Revision will dramatically accelerate the tempo of scientific research by adding to the parent grant objective biomarkers of n-3 FA levels and personnel/staff support to (1) prospectively investigate, using comparable and objective methods, the effects of n-3 FA, MeHg, and Se on CVD endpoints and (2) derive an evidence-based risk-assessment framework to quantify CVD effects of consuming specific fish species containing varying n-3 FA, MeHg, and Se. This research will overcome, for the first time, the present major limitations in the field. This Revision also will directly stimulate the U.S. economy by providing substantial job creation, including several new positions, as well as increased hours and retention of current staff and procurement of additional necessary equipment. PUBLIC HEALTH RELEVANCE: The research questions are important, novel, and timely for both science and public health policy. In addition to informing CVD risks and benefits of fish consumption and stimulating the US economy, the risk-assessment framework developed during this work will also inform future risk-benefit modeling of other key health outcomes affected by fish consumption, such as brain development in utero and infancy.

描述（由申请人提供）：科学家、政策制定者和公众/媒体对成年人摄入鱼类的健康风险和益处存在争议。有证据表明，长链n-3脂肪酸（n- 3fa）可降低心血管疾病（CVD）的风险。相反，接触某些鱼类中存在的甲基汞（MeHg）可能会增加心血管疾病的风险。鱼类也是硒（Se）的主要来源，硒是一种可以防止汞中毒的微量元素。因此，同时考虑n- 3fa、MeHg和Se的心血管疾病风险和益处是必要的，以便个人和政策制定者做出明智的决策。不幸的是，之前对鱼类摄入对心血管疾病影响的分析通常集中在甲基汞的风险或n-3 FA（或更罕见的Se）的益处上，而不是调查它们对心血管疾病健康的共同影响。对MeHg、Se和n- 3fa的总影响进行准确的定量评估，需要对同一人群中的每次暴露进行可比性和客观的生物标志物评估，并有足够数量的前瞻性确定的CVD终点和标准化的协变量评估，以尽量减少偏倚和不精确。本修订版将通过增加n-3 FA水平的客观生物标志物和人员/工作人员支持，大大加快科学研究的速度，以(1)使用可比和客观的方法前瞻性调查n-3 FA、MeHg和Se对CVD终点的影响；(2)建立基于证据的风险评估框架，量化食用含有不同n-3 FA、MeHg和Se的特定鱼类对CVD的影响。这项研究将首次克服目前该领域的主要局限。此次修订还将直接刺激美国经济，提供大量的就业机会，包括几个新职位，增加工作时间，保留现有员工，并采购额外的必要设备。