9.4 Tesla Magnetic Resonance Imaging Scanner

9.4 特斯拉磁共振成像扫描仪

• 批准号: 7497807
• 负责人: BARJOR GIMI
• 金额: $ 199.63万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497807
• 关键词: Amino Acid Neurotransmitters; Anatomy; Animal Experimentation; Animal Model; Biochemistry; Blood flow; Brain Injuries; Cardiac; Cardiovascular Diseases; Cerebrum; Clinical; Complement; Data; Diagnosis; Disease; Funding; Funding Applicant; Image; Imaging technology; Ischemia; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Medical center; Metabolism; Molecular; Molecular Medicine; Organ; Oxygen; Physiology; Public Health; Research; Research Project Grants; Resolution; Technology Assessment; Tissues; Translating; Traumatic Brain Injury; Treatment Protocols; Tumor Oxygenation; United States National Institutes of Health; angiogenesis; blood perfusion; cancer imaging; college; heart function; hemodynamics; human disease; improved; in vivo; inorganic phosphate; instrument; neovasculature; novel; programs; public health relevance; tissue oxygenation; treatment response

DESCRIPTION (provided by applicant): Funding is requested for a high resolution 9.4T magnetic resonance (MR) scanner to serve and expedite in vivo animal research at the Dartmouth College and Dartmouth Hitchcock Medical Center (DHMC). The NIH funded research programs that will exploit the MR scanner are as follows: a) Cancer imaging: tumor oxygenation and assessment of treatment response b) Neuro-imaging: Cerebral haemodynamics and Brain injury c) Cardiac imaging: Angiogenesis in the heart and function of neovasculature These research programs in Dartmouth have extensive support from NIH and its subsections for the projects above. Common denominator for these projects is that they require non-invasive imaging technology for the assessment of anatomy, physiology and biochemistry in vivo in animal models for common human diseases. Magnetic resonance imaging (MRI) not only provides a non-invasive window to body anatomy, but at the same reveals information from central parameters of organ function, including blood flow (or perfusion), blood and tissue oxygenation (to estimate oxygen metabolism). Complemented with magnetic resonance spectroscopy (MRS), data from central tissue metabolites, including high-energy phosphates and lactate, pH and amino acid neurotransmitters, are obtained. MRI provides also great potentials to image tissue at molecular level by using tagged target specific probes. These projects have proven translational potential. PUBLIC HEALTH RELEVANCE The research projects in this proposal are dealing with several public health burdens in the US, including cancer, brain traumas and cardiovascular diseases. The requested high field MR scanner will greatly advance understanding of basic mechanisms of these common diseases. It will also greatly contribute to the efforts of improving diagnosis of these conditions and thereby, it is expected to aid planning for personalized treatment protocols. The MR scanner will expedite assessment of novel cancer and anti-ischemia treatment protocols in animal models. The requested instrument will serve as a vehicle in the effort of translating molecular medicine into the clinical settings.

描述（由申请人提供）：资金要求高分辨率9.4 T磁共振（MR）扫描仪，以服务和加快在达特茅斯学院和达特茅斯希区柯克医学中心（DHMC）的体内动物研究。利用MR扫描仪的NIH资助的研究项目如下：a）癌症成像：肿瘤氧合和治疗反应评估B）神经成像：脑血流动力学和脑损伤c）心脏成像：心脏血管生成和新血管功能达特茅斯的这些研究项目得到了NIH及其子项目的广泛支持。这些项目的共同点是，它们需要非侵入性成像技术来评估常见人类疾病动物模型的体内解剖学、生理学和生物化学。磁共振成像（MRI）不仅为身体解剖结构提供了一个非侵入性的窗口，而且同时揭示了器官功能的中心参数，包括血流（或灌注），血液和组织氧合（以估计氧代谢）。补充磁共振波谱（MRS），从中央组织代谢物，包括高能磷酸盐和乳酸盐，pH值和氨基酸神经递质的数据，获得。MRI也提供了巨大的潜力，通过使用标记的目标特异性探针在分子水平上成像组织。这些项目已被证明具有转化潜力。 公共卫生相关性本提案中的研究项目涉及美国的几种公共卫生负担，包括癌症、脑创伤和心血管疾病。所要求的高场MR扫描仪将大大促进对这些常见疾病的基本机制的理解。它还将大大有助于改善这些疾病的诊断，从而有助于个性化治疗方案的规划。磁共振扫描仪将加快评估新的癌症和抗缺血治疗方案的动物模型。所要求的仪器将作为一种工具，在努力翻译分子医学到临床设置。