9.4 Tesla Magnetic Resonance Imaging Scanner

描述(由申请者提供)：达特茅斯学院和达特茅斯希区柯克医学中心(DHMC)申请资助高分辨率9.4T磁共振(MR)扫描仪，以服务和加快活体动物研究。NIH资助的将利用磁共振扫描仪的研究项目如下：a)癌症成像：肿瘤氧合和治疗反应评估b)神经成像：脑血流动力学和脑损伤c)心脏成像：心脏血管生成和新生血管的功能这些达特茅斯的研究项目得到了NIH及其分支机构对上述项目的广泛支持。这些项目的共同点是，它们需要非侵入性成像技术，用于在常见人类疾病的动物模型中评估活体解剖、生理和生化。磁共振成像(MRI)不仅为人体解剖提供了一个非侵入性的窗口，同时还揭示了器官功能的中心参数，包括血流(或灌流)、血液和组织氧合(以估计氧代谢)。与磁共振波谱(MRS)相补充，获得了来自中枢组织代谢物的数据，包括高能磷酸盐和乳酸、pH和氨基酸神经递质。磁共振成像也提供了巨大的潜力，通过使用标记的靶标特异性探针在分子水平上对组织进行成像。这些项目已被证明具有翻译潜力。 公共卫生相关性这项提案中的研究项目正在处理美国的几个公共卫生负担，包括癌症、脑创伤和心血管疾病。所要求的高场磁共振扫描仪将极大地促进对这些常见疾病的基本机制的了解。它还将极大地促进改善这些疾病的诊断的努力，因此，它有望帮助规划个性化治疗方案。磁共振扫描仪将加快在动物模型中评估新的癌症和抗缺血治疗方案。所要求的仪器将作为将分子医学转化为临床环境的努力的载体。

DESCRIPTION (provided by applicant): Funding is requested for a high resolution 9.4T magnetic resonance (MR) scanner to serve and expedite in vivo animal research at the Dartmouth College and Dartmouth Hitchcock Medical Center (DHMC). The NIH funded research programs that will exploit the MR scanner are as follows: a) Cancer imaging: tumor oxygenation and assessment of treatment response b) Neuro-imaging: Cerebral haemodynamics and Brain injury c) Cardiac imaging: Angiogenesis in the heart and function of neovasculature These research programs in Dartmouth have extensive support from NIH and its subsections for the projects above. Common denominator for these projects is that they require non-invasive imaging technology for the assessment of anatomy, physiology and biochemistry in vivo in animal models for common human diseases. Magnetic resonance imaging (MRI) not only provides a non-invasive window to body anatomy, but at the same reveals information from central parameters of organ function, including blood flow (or perfusion), blood and tissue oxygenation (to estimate oxygen metabolism). Complemented with magnetic resonance spectroscopy (MRS), data from central tissue metabolites, including high-energy phosphates and lactate, pH and amino acid neurotransmitters, are obtained. MRI provides also great potentials to image tissue at molecular level by using tagged target specific probes. These projects have proven translational potential. PUBLIC HEALTH RELEVANCE The research projects in this proposal are dealing with several public health burdens in the US, including cancer, brain traumas and cardiovascular diseases. The requested high field MR scanner will greatly advance understanding of basic mechanisms of these common diseases. It will also greatly contribute to the efforts of improving diagnosis of these conditions and thereby, it is expected to aid planning for personalized treatment protocols. The MR scanner will expedite assessment of novel cancer and anti-ischemia treatment protocols in animal models. The requested instrument will serve as a vehicle in the effort of translating molecular medicine into the clinical settings.