3T quasar dual MRI scanner for multimodal and molecular imaging

用于多模态和分子成像的 3T 类星体双 MRI 扫描仪

• 批准号: 7497388
• 负责人: RONALD J KILLIANY
• 金额: $ 194.46万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497388
• 关键词: Alcoholism; Alzheimer' s Disease; Area; Autistic Disorder; Biomedical Research; Boston; Cell Nucleus; Clinical; Communities; Data; Detection; Direct Costs; Disease; Funding; Future; Grant; Image; Inferior; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mental Health; National Center for Research Resources; Protons; Request for Proposals; Research; Research Personnel; System; Translations; United States National Institutes of Health; Universities; bioimaging; improved; instrumentation; medical schools; molecular imaging; neuroimaging; programs; public health relevance; quantum

DESCRIPTION (provided by applicant): This proposal requests $1,944,611.50 in direct costs from the National Center for Research Resources (NCRR) High-End Instrumentation Grant Program (S10) to fund a crucial 3T quasar dual MRI scanner for multimodal and molecular imaging. This new instrumentation will replace the technically significantly inferior 3T Philips Intera MRI scanner currently operational at the Center for Biomedical Imaging of the Boston University Medical School. The Center for Biomedical Imaging (CBI) is a Core Research Center of the Boston University serving both the greater Boston University and Boston area biomedical research community. Currently, a total of more than 70 different biomedical imaging projects are being performed using the existing system, ranging from longitudinal assessment of Autism Spectrum Disease, changes in cortical metabolite concentration in Alcoholism, and Alzheimers Disease Neuroimaging Initiative. The explanatory power of our current 3T scanner for these important mental health questions, however, is greatly hampered due to the limited technical capabilities of the current scanner configuration, such as low gradient strength, lack of multinuclei MR spectroscopy capability, and limited number of receive channels. The new, quasar dual 3T MRI scanner will provide a quantum jump of improvements in our Center's capability to serve the critical imaging needs of our NIH funded investigators. The major improvements are: 1. Significant enhancement of the gradient strength: from current 2.5 Gauss to 8 Gauss/cm. 2. From current proton only to broadband multi-nuclei detection capabilities. 3. From current 6-receive channels to 16-receive channels. These increased capabilities will have an immensely positive impact on the many projects presently executed, and on those that are planned for future execution on the 3T scanner (see Project Narrative for further details). PUBLIC HEALTH RELEVANCE: The vastly improved technical capabilities resulting from the requested new instrumentation will be of highest relevance for the Boston University and Boston area biomedical research community. The improvements are more than incremental, resulting in qualitatively higher level of explanatory power for the 3T MRI data obtained in our Center. This in turn is expected to greatly facilitate the translation of basic biomedical imaging results into clinical reality.

描述（由申请人提供）：本提案要求从国家研究资源中心（NCRR）高端仪器资助计划（S10）获得1,944,611.50美元的直接费用，以资助用于多模态和分子成像的关键3T类星体双MRI扫描仪。这种新仪器将取代目前在波士顿大学医学院生物医学成像中心使用的技术明显落后的3T飞利浦Intera MRI扫描仪。生物医学成像中心（CBI）是波士顿大学的核心研究中心，服务于大波士顿大学和波士顿地区的生物医学研究界。目前，共有70多个不同的生物医学成像项目正在使用现有的系统进行，包括自闭症谱系疾病的纵向评估、酒精中毒中皮质代谢物浓度的变化和阿尔茨海默病神经成像倡议。然而，由于目前扫描仪配置的技术能力有限，例如低梯度强度、缺乏多核磁共振光谱能力和接收通道数量有限，我们目前的3T扫描仪对这些重要心理健康问题的解释能力受到很大阻碍。新的类星体双3T MRI扫描仪将为我们中心的能力提供一个量子跃迁的改进，以满足我们NIH资助的研究人员的关键成像需求。主要改进有：1。梯度强度显著增强：从目前的2.5高斯到8高斯/厘米。2. 从目前的质子探测能力到宽带多核探测能力。3. 从目前的6个接收通道到16个接收通道。这些增强的功能将对目前执行的许多项目以及计划在3T扫描仪上执行的项目产生巨大的积极影响（参见项目说明了解更多细节）。