MAGNETIC RESONANCE IMAGING (MRI)

磁共振成像 (MRI)

• 批准号: 6548804
• 负责人: RONALD J KILLIANY
• 金额: $ 37.17万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6548804
• 关键词: Alzheimer's disease; aging; behavioral /social science research tag; bioimaging /biomedical imaging; brain disorder diagnosis; brain imaging /visualization /scanning; brain mapping; brain morphology; cognition disorders; genetic susceptibility; human old age (65+); human subject; longitudinal human study; magnetic resonance imaging; neuroanatomy; neurophysiology; pathologic process; patient oriented research; psychological aspect of aging

In this project, structural MRI data will be obtained at baseline from controls and non-demented subjects with cognitive impairments who will be recruited through the Clinical Core and followed over time. Subjects will be evaluated longitudinally with MRI when they cross specific transition boundaries, as defined by the Clinical Core. The overall goal of the MRI project is to determine whether structural MRI data can be used to predict which non-demented individuals with cognitive problems will develop progressive cognitive decline, which will progress to the point where they meet criteria for AD, and which will remain stable. In addition, we will seek to determine the evolution of brain changes that characterize prodromal AD, and how these measures relate to the clinical characteristics of the subjects. Underlying these goals is the assumption that structural MRI data can serve as an indirect measure of the neuronal loss that occurs when neuritic plaques and neurofibrillary tangles accumulate during the development of Alzheimer's disease (AD). In the proposed funding cycle we will use manually drawn regions of interest (R01), as we have done in the past, to evaluate atrophy in selected brain regions. We are also proposing to enhance and apply a new automated method for identifying ROIs automatically, and to compare this method to the manual measurements. Both types of MRI data will e used by other projects in the Program Project, and thus an additional responsibility of this Project is to distribute MRI images, and regions of interest derived from them, to investigators in Project by Johnson (SPECT) and Project by Sperling (fMRI). In addition, we will seek to determine the relationship between SPECT measures and other information obtained on the same individuals by the cores and the projects, including clinical data, genotype status, volumetric MRI, and fMRI signal change.

在这个项目中，结构MRI数据将在基线时从对照组和认知障碍的非痴呆受试者中获得，这些受试者将通过临床核心招募并随访一段时间。当受试者越过临床核心定义的特定过渡边界时，将通过MRI进行纵向评估。MRI项目的总体目标是确定结构MRI数据是否可以用来预测哪些有认知问题的非痴呆个体会发展为进行性认知能力下降，哪些会发展到符合AD标准的程度，哪些会保持稳定。此外，我们将试图确定表征前驱AD的大脑变化的演变，以及这些措施与受试者的临床特征之间的关系。这些目标的基础假设是，结构MRI数据可以作为在阿尔茨海默病（AD）发展过程中神经斑块和神经原纤维缠结积累时发生的神经元损失的间接测量。在提议的资助周期中，我们将使用人工绘制的感兴趣区域（R01），就像我们过去所做的那样，来评估选定大脑区域的萎缩。我们还建议增强和应用一种新的自动化方法来自动识别roi，并将该方法与人工测量进行比较。这两种类型的MRI数据将被项目项目中的其他项目使用，因此该项目的另一项责任是将MRI图像及其衍生的感兴趣区域分发给Johnson项目（SPECT）和Sperling项目（fMRI）的研究人员。此外，我们将试图确定SPECT测量与通过核心和项目获得的同一个体的其他信息之间的关系，包括临床数据，基因型状态，体积MRI和fMRI信号变化。