MAGNETIC RESONANCE IMAGING (MRI)

在这个项目中，结构性核磁共振数据将在基线上从有认知障碍的对照组和非痴呆受试者那里获得，这些受试者将通过临床核心招募并随着时间的推移进行跟踪。当受试者跨越临床核心定义的特定过渡边界时，他们将接受MRI纵向评估。MRI项目的总体目标是确定是否可以使用结构性MRI数据来预测哪些有认知问题的非痴呆者将发展为进行性认知下降，这将进展到他们符合AD标准的程度，以及哪些将保持稳定。此外，我们将寻求确定具有前驱AD特征的大脑变化的演变，以及这些测量如何与受试者的临床特征相关。这些目标背后的假设是，结构性MRI数据可以作为阿尔茨海默病(AD)发展过程中神经炎斑块和神经纤维缠结积累时发生的神经元丢失的间接测量。在拟议的资金周期中，我们将像过去一样，使用手动绘制的感兴趣区域(R01)来评估选定大脑区域的萎缩。我们还建议增强和应用一种新的自动识别ROI的方法，并将该方法与手动测量进行比较。这两种类型的MRI数据将被计划项目中的其他项目使用，因此该项目的另一项责任是将MRI图像及其衍生的感兴趣区域分发给Project by Johnson(SPECT)和Project by Sperling(FMRI)的调查人员。此外，我们将寻求确定SPECT测量与核心和项目获得的相同个体的其他信息之间的关系，包括临床数据、基因状态、体积MRI和fMRI信号变化。

In this project, structural MRI data will be obtained at baseline from controls and non-demented subjects with cognitive impairments who will be recruited through the Clinical Core and followed over time. Subjects will be evaluated longitudinally with MRI when they cross specific transition boundaries, as defined by the Clinical Core. The overall goal of the MRI project is to determine whether structural MRI data can be used to predict which non-demented individuals with cognitive problems will develop progressive cognitive decline, which will progress to the point where they meet criteria for AD, and which will remain stable. In addition, we will seek to determine the evolution of brain changes that characterize prodromal AD, and how these measures relate to the clinical characteristics of the subjects. Underlying these goals is the assumption that structural MRI data can serve as an indirect measure of the neuronal loss that occurs when neuritic plaques and neurofibrillary tangles accumulate during the development of Alzheimer's disease (AD). In the proposed funding cycle we will use manually drawn regions of interest (R01), as we have done in the past, to evaluate atrophy in selected brain regions. We are also proposing to enhance and apply a new automated method for identifying ROIs automatically, and to compare this method to the manual measurements. Both types of MRI data will e used by other projects in the Program Project, and thus an additional responsibility of this Project is to distribute MRI images, and regions of interest derived from them, to investigators in Project by Johnson (SPECT) and Project by Sperling (fMRI). In addition, we will seek to determine the relationship between SPECT measures and other information obtained on the same individuals by the cores and the projects, including clinical data, genotype status, volumetric MRI, and fMRI signal change.