Small Animal MicroCT

描述（由申请人提供）：本提案的长期目标是通过使用小动物MicroCT （Inveon MicroCT）成像技术来提高我们的知识。该仪器具有高分辨率（27微米），最适合加州大学欧文分校（UCI）的小动物研究人员使用。此外，与现有的高分辨率Inveon MicroPET相结合，它将允许多模态成像，以研究小动物的生理和生化机制，比UCI更详细。UCI的精神病学和人类行为、放射科学、药理学、生理学和生物物理学、解剖学和神经生物学、神经生物学和行为学、生物化学、医学、骨科外科、生物医学工程、放射性药物实验室和显微pet成像设备等部门都参与了使用成像方法研究正常和异常生理过程的研究。UCI的研究人员在各种条件下的人类研究中使用成像技术有着悠久的传统，UCI各个中心和部门的大量研究人员都参与了啮齿动物模型的研究。高分辨率MicroCT扫描仪的获得将使许多项目的研究人员能够以大约27微米的分辨率研究体内和体外啮齿动物模型，并协助翻译研究。UCI的研究人员首次结合高分辨率MicroPET将能够准确评估肿瘤学，心脏病学，骨学，神经科学和其他应用中的啮齿动物模型。UCI的影像研究在基础动物研究与临床研究的密切联系方面是独一无二的，这在各种项目中得到了例证。在动物模型上进行的研究将大大提高我们理解和解释人类研究的能力。新的MicroCT扫描仪将被安置在医学科学I， Inveon MicroPET被安置。本科生、研究生和住院医师在各个部门注册，接受各种非侵入性成像方法的培训。每个学生的教育程度，培训和经验根据与成像相关的课程水平和论文工作的不同，从2个月到4年不等。微型ct将是他们教育和培训的一个组成部分。MicroCT扫描仪将由Jogesh Mukherjee博士指导，来自五个不同部门（放射科学、医学、药理学、神经生物学、行为和生物化学）的团队将为MicroCT的有效操作和最大限度地利用提供必要的管理、科学和技术专业知识。

DESCRIPTION (provided by applicant): The long-term goal of this proposal is to advance our knowledge by employing imaging techniques using small animal MicroCT (Inveon MicroCT). This instrument has high resolution (27 microns) and will be most suitable for small animal investigators at University of California-Irvine (UCI). Additionally, in association with an existing high resolution Inveon MicroPET it will allow multi-modality imaging for the study of physiology and biochemical mechanisms with greater detail in small animals than has been possible at UCI. Departments of Psychiatry and Human Behavior, Radiological Sciences, Pharmacology, Physiology and Biophysics, Anatomy and Neurobiology, Neurobiology and Behavior, Biological Chemistry, Medicine, Orthopedic Surgery, Biomedical Engineering, Radiopharmaceutical Laboratories and MicroPET Imaging Facility at UCI have all been involved in using imaging methodology to study normal and abnormal physiological processes. Researchers at UCI have a long tradition of using imaging in human studies of various conditions and a large number of researchers at the various centers and Departments in UCI are involved in studying rodent models. The acquisition of a high resolution MicroCT scanner will allow researchers in numerous projects to study in vivo and in vitro rodent models with a resolution of about 27 microns and assist in translational research. For the first time, investigators at UCI in conjunction with the high resolution MicroPET will be able to accurately assess rodent models in oncology, cardiology, osteology, neurosciences and other applications. Imaging research at UCI is unique in terms of the close association of investigators in basic animal research with clinical research as exemplified in the various programs. Studies carried out on the animal models will greatly enhance our ability to understand and interpret human studies. The new MicroCT scanner will be housed in Medical Sciences I where the Inveon MicroPET is housed. Undergraduate, graduate students and residents enrolled in various departments are trained in various non- invasive imaging methods. The degree of education, training and experience vary between 2 months to 4 years for each student based on the level of courses and thesis work related to imaging. The MicroCT will be an integral part of their education and training. The MicroCT scanner will be under the direction of Dr. Jogesh Mukherjee, and a team from five different departments (Radiological Sciences, Medicine, Pharmacology, Neurobiology and Behavior and Biological Chemistry) that will provide administrative, scientific, and technical expertise necessary for the effective operation and maximal utilization of the MicroCT will be in place. PUBLIC HEALTH RELEVANCE: This is a request for a small animal MicroCT equipment. Development of diagnostic methods for the study of various cancers (breast, lung, prostate and others, including bone metastasis), diabetes, osteoporosis, coronary artery disease, neurodegenerative disorders, neuropsychiatric illness (schizophrenia, depression), substance abuse and alternative medicine approaches at University of California-Irvine will be supported by MicroCT.