PET/CT for Multidimensional Translational Cardiovascular Research

PET/CT 用于多维转化心血管研究

• 批准号: 7498749
• 负责人: John M Canty
• 金额: $ 200万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498749
• 关键词: Animal Disease Models; Animal Model; Area; Arts; Award; Blood Vessels; Buffaloes; Cardiac; Cardiomyopathies; Cardiovascular system; Cause of Death; Chronic; Clinical; Clinical Trials; Coronary heart disease; Coupled; Cyclotrons; Disease; Evaluation; Event; Family suidae; Gene Transfer; Health; Heart; Heart Diseases; Human; Hybrids; Image; Image Analysis; K-Series Research Career Programs; Medicine; Mesenchymal Stem Cells; Modeling; Myocardial; Myocardial Ischemia; Myocardium; Outcome; Patient Care; Patients; Positron-Emission Tomography; Radiochemistry; Radiopharmaceuticals; Request for Proposals; Research; Risk; Stem cells; Stents; Stroke; Structure; System; Therapeutic; Time; Tomography, Computed, Scanners; Tracer; Translational Research; Translations; United States National Institutes of Health; Universities; Vascular Diseases; X-Ray Computed Tomography; bench to bedside; cardiovascular imaging; clinically relevant; disability; dosimetry; improved; in vivo; instrument; molecular imaging; mouse model; nerve supply; novel; patient oriented research; pre-clinical; preclinical study; programs; public health relevance; repaired; sudden cardiac death

DESCRIPTION (provided by applicant): Cardiovascular molecular imaging is a rapidly emerging area offering considerable promise for the evaluation of patients with heart and vascular disease. While proof of concept studies using novel imaging agents and micro PET have been conducted in mouse models of heart disease, their translation to humans and large animal models has been problematic since the human heart is 2000 times larger and dosimetry and tracer localization are considerably different. This proposal requests support to advance preclinical and clinical translational cardiovascular molecular imaging by acquiring a hybrid positron emission tomography (PET) and multidetector computed tomography (CT) scanner dedicated to research. It will support and enhance the ongoing investigational imaging programs of seven major users (supported by 9 RO1 awards and 2 K awards focused on cardiovascular imaging). The proposed GE Discovery VCT is a state of the art PET/CT scanner that will permit preclinical studies of vascular and myocardial structure coupled with molecular imaging using novel cyclotron generated radiopharmaceuticals developed at the adjacent UB Center for Positron Emission Tomography. The Center for Research in Cardiovascular Medicine and Toshiba Stroke Center at the University at Buffalo are interdisciplinary cardiovascular research centers that are recognized leaders in translational cardiovascular imaging. NIH supported studies routinely employ advanced cardiovascular imaging in porcine models of chronic ischemic heart disease and large animal models of stroke. Besides basic mechanistic research, active programs exist in therapeutics including vascular stents, in vivo gene transfer and cardiovascular repair with stem cells (mesenchymal stem cells and endothelial progenitor cells). There is also a large ongoing NIH supported clinical trial to determine if PET can predict the risk of sudden cardiac death in patients by quantifying the extent of hibernating myocardium and imaging inhomogeneity in sympathetic innervation using 11C-Hydroxyephedrine (Prediction of Arrhythmic Events with Positron Emission Tomography). The combined institutional expertise in large animal disease models including hibernating myocardium, coronary disease, cerebrovasular disease and ischemic cardiomyopathy along with patient oriented research in cardiac PET, quantitative image analysis and radiochemistry synthesis are unique strengths of this investigative team. The proposed instrument and synergy between these two teams will facilitate rapid advancements in the field of molecular imaging as applied to the cardiovascular system. PUBLIC HEALTH RELEVANCE: Heart disease continues to be one of the leading causes of death and disability. The proposed PET/CT system will advance bench to bedside research of potentially clinically relevant therapies by focusing on research at the preclinical to clinical translational interface. Such multilevel translational research ultimately has a high likelihood of directly impacting patient care and improving health outcomes. `

描述（由申请人提供）：心血管分子成像是一个快速发展的领域，为心脏和血管疾病患者的评价提供了相当大的希望。虽然已经在心脏病的小鼠模型中进行了使用新型成像剂和微型PET的概念验证研究，但它们向人类和大型动物模型的转化一直存在问题，因为人类心脏大2000倍，并且剂量测定和示踪剂定位相当不同。该提案要求通过获取专用于研究的混合正电子发射断层扫描（PET）和多探测器计算机断层扫描（CT）扫描仪，支持推进临床前和临床转化心血管分子成像。它将支持和增强七个主要用户正在进行的研究性成像计划（由9个RO 1奖项和2个专注于心血管成像的K奖项支持）。申报的GE Discovery VCT是一种最先进的PET/CT扫描仪，可用于血管和心肌结构的临床前研究，并结合使用在相邻UB正电子发射断层扫描中心开发的新型回旋加速器产生的放射性药物进行分子成像。布法罗大学的心血管医学研究中心和东芝卒中中心是跨学科的心血管研究中心，是公认的转化心血管成像领域的领导者。NIH支持的研究常规地在慢性缺血性心脏病的猪模型和中风的大型动物模型中使用先进的心血管成像。除了基本的机制研究外，在治疗方面也存在积极的项目，包括血管支架、体内基因转移和干细胞（间充质干细胞和内皮祖细胞）的心血管修复。还有一项正在进行的NIH支持的大型临床试验，以确定PET是否可以通过量化冬眠心肌的程度和使用11 C-羟麻黄碱（正电子发射断层扫描预测心律失常事件）对交感神经支配的成像不均匀性来预测患者的心脏性猝死风险。在大型动物疾病模型（包括冬眠心肌、冠状动脉疾病、血管性疾病和缺血性心肌病）方面的机构专业知识，沿着在心脏PET、定量图像分析和放射化学合成方面以患者为导向的研究，是该研究团队的独特优势。这两个团队之间的拟议仪器和协同作用将促进分子成像领域的快速发展，应用于心血管系统。 公共卫生相关性：心脏病仍然是死亡和残疾的主要原因之一。通过专注于临床前到临床转化界面的研究，拟议的PET/CT系统将推进潜在临床相关疗法的实验室到床边研究。这种多层次的转化研究最终很有可能直接影响患者护理和改善健康结果。`