Acquisition of a 500 MHz NMR Spectrometer for the University of Southern Calif

为南加州大学购买 500 MHz NMR 波谱仪

• 批准号: 7591596
• 负责人: KYUNG W. JUNG
• 金额: $ 50万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7591596
• 关键词: Aging; Area; Arts; Basic Science; Biochemistry; Biology; California; Chemicals; Chemistry; Communities; Complex; DNA-Directed DNA Polymerase; Development; Diagnostic; Funding; Grant; Growth; Health; Human; Medical; Methodology; Methods; Molecular Probes; Molecular Structure; NMR Spectroscopy; Nanotechnology; Peptide aptamers; Pharmacologic Substance; Proteins; Research; Research Activity; Research Infrastructure; Research Project Grants; Science; Scientist; Training and Education; United States National Institutes of Health; Universities; analytical tool; base; catalyst; drug candidate; drug discovery; enzyme structure; innovation; instrument; instrumentation; nanodevice; nanoscale; programs; public health relevance; small molecule; tool

DESCRIPTION (provided by applicant): The chemical and biomolecular research community of the University of Southern California, currently funded by eighteen NIH grants, is requesting a grant support for the acquisition of a 500 MHz NMR spectrometer. This instrument is badly needed to replace aging instrumentation, which hampers the progress of our NIH- sponsored research activities. This purchase will significantly extend the availability of NMR spectroscopy to current research projects at our University Park campus and support ongoing growth of biomedical-focused chemical research. The spectrometer will support many projects that have strong biomedical relevance and clearly significant impact on human health. These range from basic research on new chemical reactivity to drug discovery, enzyme structure and function, and nanoscale medical diagnostics. Our major users are involved in research in three general areas: DNA polymerase fidelity mechanisms (Goodman, McKenna, Prakash), peptide aptamers as molecular probes (Thompson, Roberts), and new synthetic methods and small molecule-based drug discovery (Jung, Prakash, Williams, McKenna, Petasis). These research projects are producing high impact, transformative innovations in areas of synthetic methodology, complex molecule synthesis, drug discovery, development of molecular probes, biochemistry, medical diagnostics, and nanotechnology. Each of these programs requires state of the art NMR instrumentation. The requested instrument will have an immediate and lasting impact on all science conducted in the chemistry, biology, and pharmaceutical sciences departments and facilitates the training and education of undergraduate, graduate, and postdoctoral scientists at a high level. PUBLIC HEALTH RELEVANCE: NMR spectroscopy is a primary tool for the elucidation of molecular structure, and the aging infrastructure of our NMR facility is limiting the progress of eighteen NIH-sponsored research programs on our campus. The requested spectrometer will enable structural analysis of small molecule drug candidates, catalysts for new chemical methodology, and molecular probes at a level beyond our current capabilities. It will also be a key analytical tool for studying small molecule-protein interactions and optimizing new nano devices for medical diagnostics.

描述（由申请人提供）：南加州大学的化学和生物分子研究社区，目前由18个国家卫生研究院赠款资助，正在请求获得500 MHz NMR光谱仪的赠款支持。迫切需要这种仪器来取代老化的仪器，老化的仪器阻碍了我们国家卫生研究院赞助的研究活动的进展。此次收购将大大扩展NMR光谱的可用性，以我们的大学公园校园目前的研究项目，并支持生物医学为重点的化学研究的持续增长。该光谱仪将支持许多具有强烈生物医学相关性和对人类健康明显重大影响的项目。这些领域包括新化学反应的基础研究，药物发现，酶的结构和功能，以及纳米级医学诊断。我们的主要用户参与了三大领域的研究：DNA聚合酶保真度机制（Goodman，McKenna，Prakash），肽适体作为分子探针（Thompson，Roberts），以及新的合成方法和基于小分子的药物发现（Jung，Prakash，威廉姆斯，McKenna，Petasis）。这些研究项目在合成方法学、复杂分子合成、药物发现、分子探针开发、生物化学、医学诊断和纳米技术等领域产生了巨大的影响力和变革性创新。这些程序中的每一个都需要最先进的NMR仪器。所要求的仪器将对化学，生物学和制药科学部门进行的所有科学产生直接和持久的影响，并促进高水平的本科生，研究生和博士后科学家的培训和教育。公共卫生关系：NMR光谱是分子结构的阐明的主要工具，我们的NMR设施的老化基础设施限制了我们校园内18个NIH赞助的研究项目的进展。所要求的光谱仪将能够对小分子候选药物、新化学方法的催化剂和分子探针进行结构分析，其水平超出了我们目前的能力。它也将成为研究小分子-蛋白质相互作用和优化用于医学诊断的新纳米器件的关键分析工具。