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Ion Mobility Time-of-flight Mass Spectrometry System

离子淌度飞行时间质谱系统

基本信息

批准号：
7595596
负责人：
CLAUDIA S MAIER
金额：
$ 44万
依托单位：
OREGON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7595596
关键词：
Academia Acceleration Aging Area Center Core Grants Collaborations Communicable Diseases Computers and Advanced Instrumentation Coupled Disease Environment Equipment Faculty Fees Fostering Functional disorder Funding Industry Inflammatory Institution Ions Laboratories Malignant Neoplasms Mass Spectrum Analysis Mediating National Center for Research Resources National Institute of Environmental Health Sciences Nerve Degeneration Operative Surgical Procedures Oregon Oxidative Stress Policies Post-Translational Protein Processing Postdoctoral Fellow Proteins Proteome Proteomics Public Health Research Research Personnel Research Support Science Scientist Signal Transduction Students System Techniques Time Training Travel Universities Water age related biological adaptation to stress career cost experience falls instrument instrumentation ion mobility mass spectrometer metabolomics new technology programs public health relevance

项目摘要

DESCRIPTION (provided by applicant): Oregon State University (OSU) seeks funds from the NCRR to purchase a Waters quadrupole traveling wave ion mobility orthogonal acceleration time-of-flight mass spectrometer coupled to nanoAcquity UPLC system. The new instrument will support NIH-funded research programs in inflammatory, neurodegenerative and age-related disorders as well as infectious diseases. The seven major and seven secondary projects that will be supported by the new equipment fall into three areas: 1) non-covalent protein interaction studies relevant to cell signaling, oxidative stress response and aging; 2) proteomics-type applications including the identification of post- translational modifications in oxidative stress-mediated diseases, age-related dysfunctions and infectious diseases; and 3) metabolomics in inflammatory diseases and cancer. The new instrument will bring new technology to OSU including MSE capability, precursor ion selection up to 8000 Th and ion mobility separation. The instrument will be operated and maintained by OSU's Mass Spectrometry facility, which has been in operation since 1973. This shared instrumentation laboratory is currently staffed by three highly experienced faculty research associates. The operational costs of the facility are covered through institutional support, a major core center grant from the National Institute of Environmental Health Sciences and user fees. An oversight committee has been set up to coordinate administration policy and use of the instrument. The new equipment will be part of a statewide effort to establish an Oregon Proteome Consortium in which the major research universities of Oregon participate to foster collaborations in a cutting-edge research environment for advanced biomedical sciences research and provide training opportunities for young scientists on the most advanced instrumentation available. PUBLIC HEALTH RELEVANCE: The funds sought for will be used toward the purchase of an advanced mass spectrometry system which will directly impact public health by supporting research programs in infectious, inflammatory, and age-related diseases at Oregon State University and other major academic institutions in Oregon. The new equipment will promote training of students and postdoctoral researchers in modern bio-analytical techniques fostering fulfilling careers in industry and academia.

描述（由申请人提供）：俄勒冈州立大学 (OSU) 向 NCRR 寻求资金购买与 nanoAcquity UPLC 系统耦合的沃特世四极行波离子淌度正交加速飞行时间质谱仪。该新仪器将支持美国国立卫生研究院资助的炎症、神经退行性和与年龄相关的疾病以及传染病的研究项目。新设备将支持的七个主要项目和七个次要项目分为三个领域：1）与细胞信号传导、氧化应激反应和衰老相关的非共价蛋白质相互作用研究； 2）蛋白质组学类型的应用，包括鉴定氧化应激介导的疾病、年龄相关功能障碍和传染病中的翻译后修饰； 3）炎症性疾病和癌症的代谢组学。新仪器将为 OSU 带来新技术，包括 MSE 功能、高达 8000 Th 的母离子选择和离子淌度分离。该仪器将由 OSU 的质谱设施进行操作和维护，该设施自 1973 年以来一直在运行。这个共享仪器实验室目前由三名经验丰富的教职研究员组成。该设施的运营成本由机构支持、国家环境健康科学研究所的主要核心中心拨款和使用费来支付。已经成立了一个监督委员会来协调管理政策和该工具的使用。这些新设备将成为全州范围内建立俄勒冈蛋白质组联盟的一部分，俄勒冈州的主要研究型大学都参与其中，以促进先进生物医学科学研究的尖端研究环境中的合作，并为年轻科学家提供使用最先进仪器的培训机会。公共健康相关性：寻求的资金将用于购买先进的质谱系统，该系统将通过支持俄勒冈州立大学和俄勒冈州其他主要学术机构的传染病、炎症和年龄相关疾病的研究项目来直接影响公共健康。新设备将促进学生和博士后研究人员在现代生物分析技术方面的培训，从而在工业界和学术界培养充实的职业生涯。