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Biomolecular Mass Spectrometry Facility CORE

生物分子质谱设施CORE

基本信息

批准号：
8057633
负责人：
CLAUDIA S MAIER
金额：
$ 18.99万
依托单位：
OREGON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-23 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8057633
关键词：
Affect Africa Age Aging Alzheimer&apos s Disease Amides Amyloid beta-Protein Arts Atmospheric Pressure Binding Bioinformatics Biological Biological Assay Biological Markers Brain Cardiovascular Diseases Cells Charge Chelating Agents Chemicals Chile Chromatography Client Collaborations Complex Computational algorithm Computer software Copper Core Facility Crystallization DNA Data Development Devices Diet Digestion Disease Dissociation Doctor of Philosophy Drops Education Educational process of instructing Electrons Embryo Environmental Exposure Environmental Health Fatty Acids Fourier transform ion cyclotron resonance Freezing Frequencies Funding Gases Genome Goals Heart Helium Human Image Individual Inflammation Institution Ionizing radiation Isotope Labeling Isotopes Kidney Diseases Label Laboratories Lasers Lead Learning Ligands Light Lipid Peroxidation Lipids Liquid substance Magnetism Malignant Neoplasms Maps Mass Spectrum Analysis Measurement Measures Metabolic Diseases Metals Methods Microfluidic Microchips Microfluidics Mission Mitochondria Modeling Motivation Mus Nerve Degeneration Optics Oregon Oxidative Stress Oxygen Parkinson Disease Peptide Fragments Peptides Pesticides Phase Physiologic pulse Pilot Projects Plasma Population Post Translational Modification Analysis Post-Translational Protein Processing Procedures Process Protein Analysis Protein Biosynthesis Proteins Proteomics Protocols documentation Research Research Personnel Research Project Grants Resolution Resources Robotics Running SHFM1 gene Sampling Sampling Studies Scientist Services Signal Pathway Site Solutions Sorting - Cell Movement Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Staging Stress Structure System Techniques Technology Temperature Testing Therapeutic Intervention Thioctic Acid Time Tissue Sample Tissues Training Variant Vitamin E Water Work X ray diffraction analysis X-Ray Diffraction Xenobiotics Zebrafish Zinc adduct alpha synuclein ascorbate base biocomputing carcinogenesis environmental agent environmental stressor experience fatty acid oxidation graduate student health science research human tissue improved in vivo insight instrument interest ionization link protein macromolecule mass spectrometer member nanomaterials new technology next generation novel novel strategies organic contaminant overexpression oxidation particle prevent professor programs protein complex protein expression protein structure prototype quality assurance research study response single molecule small molecule stable isotope three dimensional structure toxicant urinary water sampling

项目摘要

This is the mission of the Biomolecular Mass Spectrometry Facility Core: ¿ provide exceptional support for environmental health-related research projects using state-of-the-art mass spectral analysis capabilities, ¿ develop new technologies with the ultimate goal of applying these new technologies to client projects, and ¿ serve as an educational platform for environmental health science research. The Biomolecular Mass Spectrometry Facility Core (BMSFC) gained its expertise in developing new instruments and ionization technologies over 30 years of measuring pesticides and toxicants in environmental samples. Persistent bioaccumulative toxicants are notoriously difficult to ionize and fragment by mass spectrometry. This challenge has driven much of our development efforts.

这是生物分子质谱学设备核心的任务：？使用最先进的质谱分析能力为与环境健康相关的研究项目提供特殊支持，？开发新技术，最终目标是将这些新技术应用于客户项目，以及？作为环境健康科学研究的教育平台。生物分子质谱仪核心(BMSFC)在开发新仪器和电离技术方面积累了30多年的专业知识，用于测量环境样品中的农药和有毒物质。众所周知，持久性生物蓄积性毒物很难通过质谱学进行电离和碎片。这一挑战推动了我们的大部分发展努力。