Resting State Functional MRI Investigation of Hypnotic Trance and Mindfulness Med

催眠恍惚和正念医学的静息态功能 MRI 研究

• 批准号: 7828607
• 负责人: David Spiegel
• 金额: $ 44.17万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7828607
• 关键词: Address; Affect; Area; Attention; Autonomic nervous system; Base of the Brain; Brain; Brain region; Characteristics; Cognitive; Data; Functional Magnetic Resonance Imaging; Future; Goals; Hypnosis; Image; Investigation; Measurable; Medicine; Meditation; Methodology; Mind-Body Intervention; Nervous System Physiology; Pattern; Peripheral; Personal Satisfaction; Physiological; Positron-Emission Tomography; Research Personnel; Rest; Scanning; Technology; Treatment Efficacy; experience; hypnotic; mindfulness; mindfulness meditation; neuroimaging; novel; physical conditioning; public health relevance; relating to nervous system; trait

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic 06- AT-101*: Imaging correlates of brain states. Project Summary: Our goal is to determine the functional brain networks that define and distinguish two induced states of sustained attention -- hypnosis and mindfulness -- that may be of substantial relevance to medicine. Defining the neural underpinnings of these states would have broad implications for understanding how cognitive states emerge from functional networks, how they affect peripheral autonomic nervous system activity, and how their therapeutic efficacy can be optimized. This study seeks to address three specific aims: Aim 1: To determine representative neural signatures of the hypnotic and meditative states and associated trait characteristics in highly hypnotizable subjects and experienced meditators. Aim 2: To explore similarities and differences in the neural signatures of the hypnotic and meditative states. Aim 3: To determine the brain basis for autonomic nervous system changes induced by the hypnotic and meditative states. To address these aims, we will utilize novel applications of resting state fMRI and functional connectivity analysis - methodologies which are uniquely suited to overcome the limitations of prior PET or fMRI studies -- to compare 80 subjects evenly divided across four different groups: experienced meditators, novice meditators, highly hypnotizable subjects and minimally hypnotizable subjects. Each subject will undergo a single fMRI session during which they will be scanned under three continuous ten-minute conditions of 1) rest, 2) hypnotic trance or mindfulness meditation, and 3) an attention-demanding cognitive task. We will utilize functional connectivity analyses to characterize patterns of network activity in each state. This will allow for identification of network changes that characterize the several states under investigation. This approach should allow us to identify unique, objective neural signatures of hypnosis, meditation, and cognitive task-induced focused attention. In pursuing the third aim, physiologic data collected simultaneously with the fMRI data will be used to identify brain regions related to changes in autonomic nervous system function across the states. PUBLIC HEALTH RELEVANCE: Hypnotic trance and mindfulness meditation have both been shown to have benefits for physical health. The current study seeks to determine if there are distinct patterns of brain activity that correlate with hypnotic trance, mindfulness meditation or both, and to relate these patterns to measurable markers of physical well-being. Precise neuroimaging of heightened attentional states will guide future researchers and practitioners toward more effective techniques of mind/body control.

描述（由申请人提供）：本申请涉及广泛的挑战领域（06）使能技术和特定的挑战主题06- AT-101*：大脑状态的成像相关性。项目概要：我们的目标是确定功能性大脑网络，这些网络定义和区分两种持续注意力的诱导状态-催眠和正念-这可能与医学有实质性的相关性。定义这些状态的神经基础将对理解认知状态如何从功能网络中出现，它们如何影响外周自主神经系统活动以及如何优化其治疗效果具有广泛的意义。本研究旨在解决三个具体的目标：目标1：确定代表性的神经签名的催眠和冥想状态和相关的特质特征，在高度催眠的主题和经验丰富的冥想者。目的2：探索催眠和冥想状态的神经信号的相似性和差异。目的3：探讨催眠和冥想状态下自主神经系统变化的脑机制。为了实现这些目标，我们将利用静息状态功能磁共振成像和功能连接分析的新应用-方法，这是唯一适合于克服以前的PET或功能磁共振成像研究的局限性-比较80名受试者平均分为四个不同的群体：经验丰富的冥想者，新手冥想者，高度催眠的主题和最低催眠的主题。每个受试者将接受一次功能性磁共振成像，在此期间，他们将在三个连续的10分钟条件下进行扫描：1）休息，2）催眠恍惚或正念冥想，3）需要注意力的认知任务。我们将利用功能连接分析来表征每个状态下的网络活动模式。这将允许识别网络变化，这些变化是受调查的几个州的特征。这种方法应该使我们能够识别催眠，冥想和认知任务引起的集中注意力的独特，客观的神经信号。在追求第三个目标时，与功能磁共振成像数据同时收集的生理数据将用于识别与不同状态下自主神经系统功能变化相关的大脑区域。 公共卫生相关性：催眠恍惚和正念冥想都被证明对身体健康有益。当前的研究旨在确定是否存在与催眠恍惚、正念冥想或两者相关的不同大脑活动模式，并将这些模式与身体健康的可测量标记联系起来。对高度注意状态的精确神经成像将指导未来的研究人员和实践者更有效地控制身心。