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Effectiveness of Feeding Tubes Among Person with Advanced Cognitive Impairment

饲管对晚期认知障碍患者的有效性

基本信息

批准号：
7846356
负责人：
JOAN M TENO
金额：
$ 34.11万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7846356
关键词：
Accounting Acute Address Admission activity Advance Care Planning American Hospital Association Antipsychotic Agents Area Atlases Benefits and Risks Benzodiazepines Body Weight Changes Body Weight decreased Caring Characteristics Clinical Data Data Set Decision Making Decubitus ulcer Dementia Development Disease Eating Effectiveness Elderly Employee Strikes Ensure Goals Healed Health Expenditures Healthcare Healthcare Market Hospital Nursing Hospital Referrals Hospitalization Hospitals Impaired cognition Individual Infection Institution Intervention Knowledge Life Link Marketing Medical Medicare Medicare claim Methods Nursing Homes Outcome Palliative Care Persons Pharmaceutical Preparations Pharmacy facility Policies Prevention Public Policy Quality of life Randomized Controlled Trials Recurrence Research Research Infrastructure Risk Role Selection Bias Services Site State Hospitals Time Tube Variant Work advanced dementia base comparative effectiveness editorial effectiveness research end stage disease evidence base experience healing high risk hospice environment improved inhibitor/antagonist post-market restraint trend tube feeding weight gain prevention

项目摘要

DESCRIPTION (provided by applicant): Effectiveness of Feeding Tubes Among Persons with Advanced Cognitive Impairment This application addresses broad challenge area (05) Comparative Effectiveness Research, Challenge Topic 05-AG-101: Data Infrastructure for Post-Marketing Comparative Effectiveness Studies. Advanced dementia is a common life-defining illness with a disease trajectory of eating problems, weight loss, and recurrent infections. The current use of percutaneous endoscopic gastronomy (PEG) feeding tubes in persons with advanced cognitive impairment raises two concerns. First, there is striking variation in use by states, hospital referral regions, and hospitals. This variation is in contrast to the widely cited interpretation of the existing observational data that questions the effectiveness of feeding tubes in persons with dementia. Second, this evidence base itself is imperfect. These studies rely on observational data, yet none have attempted to control for selection bias, a potential problem in any non- randomized controlled trial. Furthermore, with only two exceptions, this work has not adequately adjusted for confounders. Two recent studies have found dementia not to be an independent predictor of survival with a corresponding editorial calling for better outcomes data to judge the efficacy of feeding tubes in persons with dementia. Our previous research and preliminary studies have found that hospitals are a key locus of care and final site of decision making for feeding tube insertions among the elderly with advanced dementia. We have found that the majority of PEG feeding tube decisions are made during an acute care hospitalization for an infection, and the rate at which hospitals insert PEG feeding tubes varies from 0% to 31% of hospital admissions of nursing home residents with advanced cognitive impairment. The proposed research has two overarching goals. First, we aim to use advanced methods to account for selection bias to provide a more definitive study of the potential benefits (survival, weight change, prevention and healing of pressure ulcers), risks (use of restraints, prescription of antipsychotics or benzodiazepines, and transitions to the ER and acute care hospital), and health care expenditures. This goal will be accomplished through the linkage of four files (Medicare Claims, Minimum Data Set, American Hospital Association data, and Dartmouth Atlas of Health Care) from 1999-2008 and Medicare Part D data from 2006-2008. This analysis will examine individual-level results among persons with advanced cognitive impairment, as well as persons who receive their medical care at institutions with varying rates of PEG feeding tube insertion. A second goal is to understand the variation in hospital insertion rates of PEG feeding tubes. In this goal, we will examine potentially modifiable hospital characteristics, market factors, and state policies associated with this variation in hospitals' rate of PEG feeding tube insertion. Knowledge gained will be used to inform public policy and formulate hospital-based interventions to ensure that PEG tube insertion in persons with advance cognitive impairment is ethically appropriate and consistent with the best available data on their effectiveness. Eating problems are common issues with persons afflicted with dementia. There are two concerns with the use of feeding tubes. First, hospitals vary in their rate of feeding tube insertion despite two widely cited reviews of the evidence that question the effectiveness of feeding tubes. Second, there is controversy about the evidence of effectiveness of feeding tubes. The proposed research will provide authoritative evidence of the effectiveness of feeding tubes and identify modifiable hospital characteristics and state policies that account for the observed striking variation in feeding tube use.

描述（由申请人提供）：