REGULATION OF HIPPOCAMPAL NEUROGENESIS BY ANTIDEPRESSANTS
抗抑郁药对海马神经发生的调节
基本信息
- 批准号:7914988
- 负责人:
- 金额:$ 39.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-08 至 2010-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAffectAntidepressive AgentsApplications GrantsBehaviorBehavioralBrain-Derived Neurotrophic FactorC57BL/6 MouseChronicChronic stressCitalopramCorticosteroneDiseaseEmotionalExposure toFlow CytometryFluoxetineFunctional disorderGeneticGenetic Predisposition to DiseaseGoalsHippocampus (Brain)HormonesHousingIntraventricular InfusionInvestigationLaboratoriesLeadMajor Depressive DisorderMeasuresMediator of activation proteinMedicalModelingMorbidity - disease rateMouse StrainsMusNeuronal PlasticityParahippocampal GyrusPatientsPharmaceutical PreparationsPharmacologyPlayProceduresProductionPublic HealthRecoveryRegulationRodentRoleStressTechniquesTestingTherapeutic Effectadult neurogenesisdentate gyrusdepressiondepressive symptomseconomic impacthypothalamic-pituitary-adrenal axismouse modelneurogenesisneurotrophic factornovelreboxetineresilienceresponsetreatment effect
项目摘要
This proposal examines how the regulation of adult neurogenesis produced by
repeated antidepressant drug treatment in mice may contribute to behavioral recovery
from stress and depression. Major depressive disorder results from convergent
underlying genetic predispositons and exposure to environmental stress. Evidence for
increases of neurogenesis in the adult dentate gyrus of the hippocampus are a model for
changes in neuroplasticity that emerge with chronic treatment with antidepressant drugs
and serve as a model for the production of therapeutic effects. Most studies have
measured the effects of antidepressants using rodents under routine housing conditions
and have ignored the critical role of genetics and stress in contributing to drug treatment
effects. We have identified a mouse strain (MRL/MpJ) that shows larger increases in
neurogenesis following chronic fluoxetine. Also, the addition of stress hormones
augments the effects of fluoxetine on neurogenesis in a nonresponder mouse strain
(C57BL/6). The central hypothesis of this grant proposal is that genetic predispositions
and stress produce a critical role for revealing the effects of chronic antidepressant
treatments on hippocampal neurogenesis. The use of flow cytometry as a technique to
measure neurogenesis rapidly developed by this laboratory will enable completion of the
large number of studies required for investigation of the pharmacology of neurogenesis.
The primary goals of this proposal are: 1) demonstrate the critical role of exposure to
corticosterone (CORT) in augmenting responses to chronic treatment with antidepressant
drugs on neurogenesis and behavior in a responder and nonresponder mouse strain; 2)
show whether environmental stress plays a similar role in causing antidepressant drugs
to alter neurogenesis and behavior; and 3) determine whether hippocampal BDNF serves
as a mechanism underlying
这一建议探讨了成人神经发生的调节是如何产生的
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Fluoxetine treatment induces dose dependent alterations in depression associated behavior and neural plasticity in female mice.
- DOI:10.1016/j.neulet.2010.07.084
- 发表时间:2010-10-22
- 期刊:
- 影响因子:2.5
- 作者:Hodes GE;Hill-Smith TE;Lucki I
- 通讯作者:Lucki I
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IRWIN LUCKI其他文献
IRWIN LUCKI的其他文献
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{{ truncateString('IRWIN LUCKI', 18)}}的其他基金
Kappa Receptor Antagonists as Rapid Acting Antidepressants
Kappa 受体拮抗剂作为速效抗抑郁药
- 批准号:
9030490 - 财政年份:2016
- 资助金额:
$ 39.32万 - 项目类别:
Kappa Receptor Antagonists as Rapid Acting Antidepressants
Kappa 受体拮抗剂作为速效抗抑郁药
- 批准号:
9753367 - 财政年份:2016
- 资助金额:
$ 39.32万 - 项目类别:
Regulation of Hippocampal Neurogenesis by Antidepressants
抗抑郁药对海马神经发生的调节
- 批准号:
8111695 - 财政年份:2010
- 资助金额:
$ 39.32万 - 项目类别:
Regulation of Hippocampal Neurogenesis by Antidepressants
抗抑郁药对海马神经发生的调节
- 批准号:
8471195 - 财政年份:2010
- 资助金额:
$ 39.32万 - 项目类别:
Regulation of Hippocampal Neurogenesis by Antidepressants
抗抑郁药对海马神经发生的调节
- 批准号:
7987729 - 财政年份:2010
- 资助金额:
$ 39.32万 - 项目类别:
Regulation of Hippocampal Neurogenesis by Antidepressants
抗抑郁药对海马神经发生的调节
- 批准号:
8267123 - 财政年份:2010
- 资助金额:
$ 39.32万 - 项目类别:
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