Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICS

CNICS 综合临床科学 CFAR 网络主动提供的 R24

• 批准号: 7926709
• 负责人: Michael S. Saag
• 金额: $ 182.58万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-22 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7926709
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adherence; Affect; Award; Basic Science; Behavioral; Behavioral Sciences; Bioethics; Biological; Caring; Cessation of life; Clinic; Clinical; Clinical Data; Clinical Investigator; Clinical Sciences; Clinical Treatment; Clinical Trials; Cohort Studies; Collaborations; Collection; Combined Modality Therapy; Commit; Complement; Computer software; Computerized Medical Record; Data; Data Analyses; Data Collection; Data Element; Data Quality; Data Set; Databases; Decision Making; Development; Disease Management; Disease Progression; Documentation; Epidemic; Epidemiology; Event; Fostering; Future; Goals; HIV; HIV Infections; Highly Active Antiretroviral Therapy; Individual; Information Systems; Interview; Link; Measures; Medical Informatics; Medical Records; Methodology; Methods; Monoclonal Antibody R24; Morphology; Natural History; Outcome; Outcomes Research; Pathogenesis; Patient Care; Patients; Point-of-Care Systems; Positioning Attribute; Principal Investigator; Procedures; Quality Control; Questionnaires; Randomized Controlled Clinical Trials; Reporting; Research; Research Infrastructure; Research Personnel; Resource Development; Resources; Sampling; Site; Software Tools; Source; Specimen; Standardization; Structure; Substance abuse problem; System; Systems Integration; Toxic effect; United States; Work; abstracting; antiretroviral therapy; base; clinical care; clinical research site; cohort; data sharing; flexibility; immune function; novel; novel strategies; point of care; population based; prospective; repository; response; success; systems research; transmission process

The clinical treatment of HIV/AIDS in the era of Highly Active Anti-Retroviral Therapy (HAART) is extremely dynamic with unprecedented combinations of therapies and a myriad of patient and virologic responses to therapy. Long-term outcomes research is necessary to provide clinicians with up-to-date information on the best strategies to employ in their patients' individual situations. Historically, evidence for clinical care decisions has been generated through the conduct of randomized controlled clinical trials, epidemiology- based prospective clinical cohorts, and anecdotal reports. A new approach that will synergize with these methods is outcomes research based on the utilization of data derived directly from newly developed electronic medical record (EMR) systems and compiling such data into novel research networks. Such EMR systems are already in existence at several Centers for AIDS Research (CFAR) sites in the United States. The CFAR Network of Integrated Clinical Systems (CNICS) project is the first such resource network that can substantially contribute to the contemporary HIV research agenda. As a clinic-based research network, CNICS directly reflects the outcomes of clinical decisions and management options used daily in the care of HIV infected individuals. Unlike data collected in structured interviews or through retrospective medical record review, CNICS assures a broader range of information associated with the rapidly changing course of HIV disease management through collection of data at the point of care. The CNICS project supports a data system that is a central repository of verified and quality-controlled data from the EMRs at seven CFAR sites. The EMR data recorded for individual patient care are made available through CNICS for population-based outcomes research, which facilitates networking and contributes to the standardization of data contained in the CNICS data system. CNICS is also developing a specimen repository linked with clinical data from the sites' EMRs. CNICS is a unique resource for HIV clinical, translational, and basic research and will provide the infrastructure and data to address the challenging and rapidly evolving issues in HIV care and research. The principle goals of this proposal are to build and support the CNICS infrastructure, to address the challenging research agenda of the evolving HIV epidemic, to prepare for the expansion of CNICS by developing standard operating procedures and software tools to facilitate data quality control and transmission, to expand CNICS by 8 to 10 sites within 5 years, and to serve as a resource for the development of similar research networks.

高度活跃的抗逆转录病毒治疗（HAART）的艾滋病毒/艾滋病的临床治疗极为 动态，疗法的前所未有的组合以及对 治疗。长期结果研究是为了为临床医生提供有关该临床医生的最新信息。 在患者的个人情况下采用的最佳策略。从历史上看，临床护理的证据 通过进行随机对照临床试验，流行病学 - 基于前瞻性临床人群和轶事报告。一种将与这些协同作用的新方法 方法是基于直接从新开发的数据的利用来实现研究 电子病历（EMR）系统并将此类数据汇编成新的研究网络。这样的EMR 在美国的艾滋病研究中心（CFAR）的几个中心已经存在系统。 集成临床系统（CNIC）项目的CFAR网络是第一个这样的资源网络 可以为当代艾滋病毒研究议程做出重大贡献。作为基于诊所的研究网络， CNIC直接反映了每天用于照顾的临床决策和管理方案的结果 艾滋病毒感染的人。与结构化访谈或通过回顾性医学收集的数据不同 记录评论，CNIC确保与快速变化的过程相关的更广泛的信息 艾滋病毒疾病通过在护理点收集数据来管理。 CNIC项目支持数据 系统是来自七个CFAR站点的EMR的经过验证和质量控制数据的中央存储库。 通过CNIC为基于人群的CNIC提供了针对个别患者护理的EMR数据 成果研究，促进网络并有助于包含的数据的标准化 CNIC数据系统。 CNIC还正在开发一个标本存储库，该存储库与来自 站点的EMR。 CNIC是HIV临床，转化和基础研究的独特资源，将提供 基础架构和数据旨在解决艾滋病毒护理和研究中具有挑战性和快速发展的问题。这 该提案的主要目标是建立和支持CNICS基础设施，以解决具有挑战性 不断发展的艾滋病毒流行的研究议程，以为扩大CNIC的发展而发展 标准操作程序和软件工具，以促进数据质量控制和传输， 在5年内将CNIC扩大8到10个地点，并作为开发类似的资源 研究网络。