Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICS

CNICS 综合临床科学 CFAR 网络主动提供的 R24

• 批准号: 7926709
• 负责人: Michael S. Saag
• 金额: $ 182.58万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-22 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7926709
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adherence; Affect; Award; Basic Science; Behavioral; Behavioral Sciences; Bioethics; Biological; Caring; Cessation of life; Clinic; Clinical; Clinical Data; Clinical Investigator; Clinical Sciences; Clinical Treatment; Clinical Trials; Cohort Studies; Collaborations; Collection; Combined Modality Therapy; Commit; Complement; Computer software; Computerized Medical Record; Data; Data Analyses; Data Collection; Data Element; Data Quality; Data Set; Databases; Decision Making; Development; Disease Management; Disease Progression; Documentation; Epidemic; Epidemiology; Event; Fostering; Future; Goals; HIV; HIV Infections; Highly Active Antiretroviral Therapy; Individual; Information Systems; Interview; Link; Measures; Medical Informatics; Medical Records; Methodology; Methods; Monoclonal Antibody R24; Morphology; Natural History; Outcome; Outcomes Research; Pathogenesis; Patient Care; Patients; Point-of-Care Systems; Positioning Attribute; Principal Investigator; Procedures; Quality Control; Questionnaires; Randomized Controlled Clinical Trials; Reporting; Research; Research Infrastructure; Research Personnel; Resource Development; Resources; Sampling; Site; Software Tools; Source; Specimen; Standardization; Structure; Substance abuse problem; System; Systems Integration; Toxic effect; United States; Work; abstracting; antiretroviral therapy; base; clinical care; clinical research site; cohort; data sharing; flexibility; immune function; novel; novel strategies; point of care; population based; prospective; repository; response; success; systems research; transmission process

The clinical treatment of HIV/AIDS in the era of Highly Active Anti-Retroviral Therapy (HAART) is extremely dynamic with unprecedented combinations of therapies and a myriad of patient and virologic responses to therapy. Long-term outcomes research is necessary to provide clinicians with up-to-date information on the best strategies to employ in their patients' individual situations. Historically, evidence for clinical care decisions has been generated through the conduct of randomized controlled clinical trials, epidemiology- based prospective clinical cohorts, and anecdotal reports. A new approach that will synergize with these methods is outcomes research based on the utilization of data derived directly from newly developed electronic medical record (EMR) systems and compiling such data into novel research networks. Such EMR systems are already in existence at several Centers for AIDS Research (CFAR) sites in the United States. The CFAR Network of Integrated Clinical Systems (CNICS) project is the first such resource network that can substantially contribute to the contemporary HIV research agenda. As a clinic-based research network, CNICS directly reflects the outcomes of clinical decisions and management options used daily in the care of HIV infected individuals. Unlike data collected in structured interviews or through retrospective medical record review, CNICS assures a broader range of information associated with the rapidly changing course of HIV disease management through collection of data at the point of care. The CNICS project supports a data system that is a central repository of verified and quality-controlled data from the EMRs at seven CFAR sites. The EMR data recorded for individual patient care are made available through CNICS for population-based outcomes research, which facilitates networking and contributes to the standardization of data contained in the CNICS data system. CNICS is also developing a specimen repository linked with clinical data from the sites' EMRs. CNICS is a unique resource for HIV clinical, translational, and basic research and will provide the infrastructure and data to address the challenging and rapidly evolving issues in HIV care and research. The principle goals of this proposal are to build and support the CNICS infrastructure, to address the challenging research agenda of the evolving HIV epidemic, to prepare for the expansion of CNICS by developing standard operating procedures and software tools to facilitate data quality control and transmission, to expand CNICS by 8 to 10 sites within 5 years, and to serve as a resource for the development of similar research networks.

在高效抗逆转录病毒治疗（HAART）时代，HIV/AIDS的临床治疗极其困难， 动态的前所未有的组合疗法和无数的病人和病毒学反应， 疗法长期结果研究是必要的，以提供临床医生的最新信息， 最好的策略来运用在他们的病人的个人情况。历史上，临床护理的证据 通过进行随机对照临床试验、流行病学- 基于前瞻性临床队列和轶事报告。一种新的方法，将协同这些 方法是成果研究的基础上利用数据直接来自新开发的 电子病历（EMR）系统，并将这些数据编译成新的研究网络。此类EMR 在美国的几个艾滋病研究中心（CFAR）的站点已经存在这种系统。 CFAR综合临床系统网络（CNICS）项目是第一个这样的资源网络， 可以为当代艾滋病毒研究议程做出重大贡献。作为一个基于临床的研究网络， CNICS直接反映了临床决策的结果和日常护理中使用的管理选项， 艾滋病毒感染者。与通过结构化访谈或回顾性医疗调查收集的数据不同， 通过记录审查，CNICS确保与快速变化的过程相关的更广泛的信息， 通过在护理点收集数据进行艾滋病毒疾病管理。CNICS项目支持一个数据 该系统是一个中央储存库，储存来自七个CFAR站点的EMR的经核实和质量控制的数据。 为个别病人护理记录的电子病历数据可通过CNICS提供， 成果研究，这有助于建立网络，并有助于数据标准化， CNICS数据系统。CNICS还正在开发一个与临床数据相关联的标本库， 研究中心的EMR。 CNICS是HIV临床、转化和基础研究的独特资源，将提供 基础设施和数据，以解决艾滋病毒护理和研究中具有挑战性和迅速发展的问题。的 本提案的主要目标是建立和支持计算机网络信息控制系统基础设施，以解决 艾滋病毒流行病演变的研究议程，通过制定 标准作业程序和软件工具，以便利数据质量控制和传输， 在5年内将CNICS扩大8至10个站点，并作为开发类似 研究网络。