UAB Center for AIDS Research

阿拉巴马大学艾滋病研究中心

• 批准号: 8110793
• 负责人: Michael S. Saag
• 金额: $ 61.46万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8110793
• 关键词: UAB; Center; AIDS; Research

The mission of the UAB CFAR is to stimulate and support multidisciplinary basic, behavioral, clinical and translational AIDS research so as to hasten the development of effective treatments and prevention strategies for AIDS. For 20 years, the Center has played a vital role in supporting cutting edge research activities of its members that have led to paradigm-shifting discoveries, including: the discovery of HIV-1 quasispecies diversity (Nature 1988), detection of HIV-1 RNA in plasma (Science 1993), viral dynamics in acute and chronic infection (NEJM 1991; Nature 1995), HIV-1 escape from cytotoxic T-cells (Nat Medicine 1997) and neutralizing antibodies (Nature 2003), first-in-human phase 1 clinical studies of 7 currently approved therapies (NEJM 1993; Nat Medicine 1998; JAMA 2006), the zoonotic origins of HIV-1 (Nature 1999; Nature 2006; Science 2006), and the identification of the transmitted HIV-1 envelope and complete genome/proteome responsible for HIV infection (PNAS 2008). A common thread connecting all of these discoveries is the proactive participation of the CFAR in facilitating basic, translational and clinical research through effective collaboration between basic and clinical investigators. The objectives of the CFAR reflect this continuing commitment to innovative, multidisciplinary AIDS research and include: 1. To provide a central institutional focus for HIV/AIDS research activities that emphasize effective communication and collaboration among CFAR members and the wider HIV/AIDS research community. 2. To enhance productivity of ongoing research programs by encouraging interdisciplinary research and by providing critical shared resource facilities and administrative and fiscal management support to Center investigators. 3. To use robust strategic planning methods to identify new research opportunities and priorities, to align them with existing CFAR programs, and to foster new research programs where none are in existence but where faculty interest and University capacity is evident. 4. To stimulate the entry of junior and established faculty into HIV/AIDS research programs. This is accomplished through mentoring young investigators and by a peer-reviewed Developmental Grants Program. 5. To stimulate faculty recruitment and program development in areas that reflect the ongoing evolution of HIV/AIDS research and the global epidemic. The Center is comprised of 163 Center members from 35 Divisions and Departments within UAB funded by current AIDS-related grants and contracts totaling more than $87.2 million. Nine Core Facilities are proposed that provide vital support for the Center's principal thematic areas of viral pathogenesis, experimental therapeutics, global health, prevention and vaccine development. The success of the UAB CFAR in stimulating HIV/AIDS research is reflected in the growth in NIH extramural funding for AIDS-related research from $6.0 million in NIH funding in 1988 to over $26 million currently, in over 2500 research publications over the past six year grant period, in the recruitment of more than 21 HIV/AIDS investigators since 2QQ2, and in the garnering of strong Institutional support.

UAB CFAR的使命是促进和支持多学科基础， 艾滋病的行为、临床和转化研究，以加速艾滋病有效治疗和预防策略的发展。20年来，该中心在支持其成员的前沿研究活动方面发挥了至关重要的作用，这些活动导致了范式转变的发现，包括：（Nature 1988），血浆中HIV-1 RNA的检测（Science 1993），急性和慢性感染中的病毒动力学（NEJM 1991; Nature 1995），HIV-1从细胞毒性T细胞逃逸（Nat Medicine 1997）和中和抗体（Nature 2003），7种目前批准的疗法的首次人体I期临床研究（NEJM 1993; Nat Medicine 1998; JAMA 2006）、HIV-1的人畜共患病起源（Nature 1999; Nature 2006; Science 2006）和HIV-1的人畜共患病起源（Nat Medicine 1998; JAMA 2006）。 鉴定传播的HIV-1包膜和负责HIV感染的完整基因组/蛋白质组（PNAS 2008）。连接所有这些发现的一个共同点是CFAR通过基础和临床研究者之间的有效合作，积极参与促进基础，转化和临床研究。该基金的目标反映了对创新性、多学科艾滋病研究的持续承诺，包括： 1.为艾滋病毒/艾滋病研究活动提供一个中心机构重点，强调CFAR成员和更广泛的艾滋病毒/艾滋病研究界之间的有效沟通和合作。 2.通过鼓励跨学科研究，并通过为中心研究人员提供关键的共享资源设施和行政和财政管理支持，提高正在进行的研究计划的生产力。 3.使用强大的战略规划方法来确定新的研究机会和优先事项，使其与现有的CFAR计划保持一致，并促进新的研究计划，其中没有存在，但教师的兴趣和大学的能力是显而易见的。 4.鼓励初级和建立教师进入艾滋病毒/艾滋病研究方案。这是通过指导年轻的研究人员和同行评审的发展赠款计划来实现的。 5.促进教师招聘和反映艾滋病毒/艾滋病研究和全球流行病的持续发展领域的计划发展。 该中心由来自UAB内35个司和部门的163名中心成员组成，由目前与艾滋病有关的赠款和合同资助，总额超过8720万美元。九个核心设施的建议，提供至关重要的支持，该中心的主要专题领域的病毒发病机制，实验疗法，全球健康， 预防和疫苗开发。UAB CFAR在刺激艾滋病毒/艾滋病研究方面的成功反映在NIH对艾滋病相关研究的校外资助从1988年的600万美元增加到目前的2600多万美元，在过去六年的资助期内发表了2500多篇研究论文，招募了超过1000名研究人员，以及在2008年的资助期内发表了2500多篇研究论文。 自第二季度以来，21名艾滋病毒/艾滋病调查员获得了强有力的机构支持。