Inflamation and the Risk of Endometrial Cancer

炎症与子宫内膜癌的风险

• 批准号: 7877739
• 负责人: Akila Viswanathan
• 金额: $ 13.45万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-31 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7877739
• 关键词: Acetaminophen; Alleles; Angiogenic Factor; Anti-Inflammatory Agents; Anti-inflammatory; Area; Aspirin; Attenuated; Biological Markers; Biological Response Modifiers; C-reactive protein; CYP2C9 gene; Cancer Biology; Cancer Center; Cancer Control; Case-Control Studies; Cell Proliferation; Cells; Chronic; Colon Adenocarcinoma; Commit; Complex; Consumption; Data; Databases; Development; Devices; Disease; Dose; Endocrine; Endometrial; Endometrial Carcinoma; Ensure; Enzymes; Epidemiologic Studies; Epidemiology; Equilibrium; Estrogens; Etiology; Future; Genetic Polymorphism; Genotype; Goals; Grant; Growth; Growth Factor; Health; Human; Immune system; Incidence; Individual; Inflammation; Inflammatory; Injury; Interleukin-6; Investigation; Knowledge; Luteal Phase; Malignant Female Reproductive System Neoplasm; Mediator of activation protein; Menstruation; Mentors; Metabolism; Modeling; Mutate; Mutation; Non-Steroidal Anti-Inflammatory Agents; Nurses' Health Study; Organ; Pancreatic Adenocarcinoma; Pharmaceutical Preparations; Population; Progesterone; Prospective Studies; Public Health; Public Health Schools; Publications; Questionnaires; Regulation; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Tissues; Training; Uterus; Variant; Woman; Wound Healing; base; cancer epidemiology; cancer risk; carcinogenesis; career; case control; cell growth; cohort; cytokine; endometrial cancer prevention; experience; inflammatory marker; insight; medical schools; prospective; protective effect; repaired; skills; tumor

DESCRIPTION (provided by applicant): Through the integration of a mentored research experience with formal coursework at the Harvard School of Public Health, this proposal will support and enrich the development of Akila N. Viswanathan, MD, MPH, as an investigator committed to an academic career in cancer control and epidemiology. The proposed research will analyze risk factors for endometrial cancer using the Nurses' Health Study database. The analyses will focus on understanding the role of inflammation in the development of endometrial cancer. In Aim 1, the proposed research project will clarify the role of anti-inflammatory medications, including aspirin and non-steroidal anti-inflammatory drugs, in relation to the risk of endometrial cancer and contrast these results to those of acetaminophen, which is not an anti-inflammatory medication. The role of genetic polymorphisms of the enzymes CYP2C9 and UGT1A6 in the metabolism of aspirin in relation to its effect will be studied. Since the role of treatment with anti-inflammatory drugs has not been analyzed in any prior epidemiologic study, this research will provide a more thorough understanding of the underlying etiology and biology of this cancer and provide public health information on the impact of consumption of these agents with regard to dose and duration of use. In Aim 2, we will examine the role of increased inflammation on the risk of endometrial cancer. Specifically, this project will analyze the role of the pro-inflammatory intra-uterine device (IUD) using the Nurses' Health Study prospective cohorts. The role of markers of systemic inflammation will be assessed by a nested case-control analysis of the biomarkers C-reactive protein and interleukin-6, providing the first analysis of these biomarkers in relation to endometrial cancer risk. All analyses will be performed by Dr. Viswanathan. She will acquire experience in analyzing prospective cohort and case-control studies, questionnaires, biomarkers, and genetic polymorphisms. The results of this proposed research will provide important new information about the etiology of endometrial cancer and assist with the assessment of future population risk. Through this grant, Dr. Viswanathan will obtain a doctoral degree in epidemiology, and thereby will have the requisite training to become a true expert in the field. This proposal will ensure that she will become an established independent investigator and a leading expert in gynecologic cancer epidemiology.

描述（由申请人提供）：通过将受指导的研究经验与哈佛大学公共卫生学院的正式课程相结合，该提案将支持和丰富 Akila N. Viswanathan（医学博士、公共卫生硕士）作为致力于癌症控制和流行病学学术生涯的研究者的发展。拟议的研究将利用护士健康研究数据库分析子宫内膜癌的危险因素。分析的重点是了解炎症在子宫内膜癌发展中的作用。在目标 1 中，拟议的研究项目将阐明抗炎药物（包括阿司匹林和非甾体抗炎药物）与子宫内膜癌风险相关的作用，并将这些结果与对乙酰氨基酚（不是抗炎药物）的结果进行对比。将研究酶 CYP2C9 和 UGT1A6 的遗传多态性在阿司匹林代谢中的作用及其效果。由于之前的任何流行病学研究都没有分析过抗炎药物治疗的作用，因此这项研究将更全面地了解这种癌症的潜在病因和生物学，并提供有关服用这些药物的剂量和使用时间影响的公共卫生信息。在目标 2 中，我们将研究炎症增加对子宫内膜癌风险的影响。具体来说，该项目将利用护士健康研究前瞻性队列分析促炎宫内节育器 (IUD) 的作用。系统性炎症标志物的作用将通过生物标志物 C 反应蛋白和白细胞介素 6 的巢式病例对照分析进行评估，从而首次分析这些生物标志物与子宫内膜癌风险的关系。所有分析将由 Viswanathan 博士进行。她将获得分析前瞻性队列和病例对照研究、问卷、生物标志物和遗传多态性的经验。这项拟议研究的结果将提供有关子宫内膜癌病因学的重要新信息，并有助于评估未来的人群风险。通过这笔赠款，维斯瓦纳坦博士将获得流行病学博士学位，从而接受必要的培训，成为该领域的真正专家。该提案将确保她成为妇科癌症流行病学领域的知名独立研究者和领先专家。

项目成果

Circulating melatonin and the risk of breast and endometrial cancer in women.

• DOI: 10.1016/j.canlet.2008.11.002
• 发表时间: 2009-08-18
• 期刊: CANCER LETTERS
• 影响因子: 9.7
• 作者: Viswanathan, Akila N.;Schernhammer, Eva S.
• 通讯作者: Schernhammer, Eva S.

Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients.

• DOI: 10.1016/j.ijrobp.2008.12.016
• 发表时间: 2009-04-01
• 期刊: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
• 影响因子: 7
• 作者: Wo, Jennifer Y.;Viswanathan, Akila N.
• 通讯作者: Viswanathan, Akila N.

Aspirin, NSAID, and acetaminophen use and the risk of endometrial cancer.

阿司匹林、非甾体抗炎药和对乙酰氨基酚的使用与子宫内膜癌的风险。

• DOI: 10.1158/0008-5472.can-07-6257
• 发表时间: 2008
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Viswanathan,AkilaN;Feskanich,Diane;Schernhammer,EvaS;Hankinson,SusanE
• 通讯作者: Hankinson,SusanE

American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part II: high-dose-rate brachytherapy.

• DOI: 10.1016/j.brachy.2011.07.002
• 发表时间: 2012-01
• 期刊: BRACHYTHERAPY
• 影响因子: 1.9
• 作者: Viswanathan, Akila N.;Beriwal, Sushil;De Los Santos, Jennifer F.;Demanes, D. Jeffrey;Gaffney, David;Hansen, Jorgen;Jones, Ellen;Kirisits, Christian;Thomadsen, Bruce;Erickson, Beth
• 通讯作者: Erickson, Beth

A novel low dose fractionation regimen for adjuvant vaginal brachytherapy in early stage endometrioid endometrial cancer.

一种新型低剂量分次治疗方案，用于早期子宫内膜样子宫内膜癌的辅助阴道近距离治疗。

• DOI: 10.1016/j.ygyno.2012.07.111
• 发表时间: 2012
• 期刊: Gynecologic oncology
• 影响因子: 4.7
• 作者: Townamchai,Kanokpis;Lee,Larissa;Viswanathan,AkilaN
• 通讯作者: Viswanathan,AkilaN