Treatment of Tourette's Syndrome & Obsessive-Compulsive Disorder

描述（由申请人提供）：本申请是NIMH高级科学家奖（K05）的申请。自20世纪80年代以来，我和我在耶鲁大学儿童研究中心的同事们在改善对图雷特综合症和早发性强迫症的发病机制和治疗的理解方面做出了重大贡献。所要求的K05奖将使我有可能继续专注于学术追求，从而进一步推进我的研究和教育活动。在这个资深科学家奖期间，我有两个目标。首先，我打算继续探索前瞻性纵向研究的效用，以增加我们对TS和早发性强迫症的过程和结果的决定因素的知识，使用最先进的临床评估方法（症状严重程度，社会心理压力水平），基因组学，免疫生物学，应激反应的神经内分泌学和体内神经影像学。这将涉及与各个学科的研究人员和受训者合作，完成资助资助，分析现有数据集，准备新的资助申请以及竞争性续期。其次，在我职业生涯的下一个阶段，我计划完善一个模范课程，部分基于美国内科医学委员会的研究途径和美国精神病学和神经病学委员会的三重委员会计划，该计划已在全国三家机构实施-耶鲁大学，科罗拉多大学和杜克大学。在耶鲁大学，这个名为“Albert J. Solnit综合儿童和青少年精神病学（ICAP）住院医师培训途径”的项目于2004年开始实施，招收了两位致力于学术儿童精神病学事业的杰出人士。耶鲁大学的ICAP研究路径是我们跨学科研究培训计划的一部分。我还计划准备一项会议拨款，以支持一个全国性的学术儿童精神病学家论坛，这些儿童精神病学家将在全国各地参加ICAP研究途径项目之一。最后，我期待着完成我作为国家精神病学培训委员会联合主席的工作，在成瘾精神病学和老年精神病学的其他精神病学亚专业中引入精心设计的模式课程。

DESCRIPTION (provided by applicant): This application is for a Senior Scientist Award (K05) from NIMH. Since the 1980s, my colleagues and I at the Child Study Center at Yale have made significant contributions to an improved understanding of the pathogenesis and treatment of Tourette's syndrome and early-onset obsessive-compulsive disorder. The requested K05 Award would make it possible for me to maintain my focus on academic pursuits and thereby further advance my research and educational activities. I have two goals for the period of this Senior Scientist Award. First, I intend to continue to explore the utility of prospective longitudinal studies to add to our knowledge about the determinants of course and outcome of TS and early-onset OCD using state-of-the- art methods for clinical assessment (symptom severity, level of psychosocial stress), genomics, immunobiology, neuroendocrinology of stress response, and in vivo neuroimaging. This will involve working with investigators and trainees across a range of disciplines, completing funded grants, analyzing existing data sets and preparing new grant applications as well as competitive renewals. Second, during this next phase of my career, I plan to refine a model curriculum, based in part on the American Board of Internal Medicine's Research Pathway and the American Board of Psychiatry and Neurology's Triple Board Program that has been implemented at three sites nationally - Yale, University of Colorado and Duke. At Yale, this program, entitled, the "Albert J. Solnit Integrated Child and Adolescent Psychiatry (ICAP) Residency Training Pathway," was implemented in 2004 with the admission of two outstanding individuals committed to careers in academic child psychiatry. This ICAP Research Pathway at Yale is one part of our interdisciplinary research training program. I also plan to prepare a conference grant to support a national forum for future academic child psychiatrists that are enrolled in one of the ICAP Research Pathway programs at sites around the country. Finally, I am looking forward to completing my work as the Co-chair of the National Psychiatry Training Council with the introduction of carefully crafted model curricula in other psychiatric subspecialties of addiction psychiatry and geriatric psychiatry.