Biostatistics Core

生物统计学核心

• 批准号: 7854639
• 负责人: SARAH E HOLTE
• 金额: $ 16.11万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7854639
• 关键词: Address; Area; Autologous; Binomial Distribution; Biological Assay; Biometry; Biostatistics Core; Characteristics; Clinical; Clinical Data; Collaborations; Complex; Computer Simulation; Computer software; Data; Data Analyses; Data Collection; Data Set; Databases; Development; Doctor of Philosophy; Evolution; Generations; Genital system; Genomics; HIV; HIV-1; Immune response; In Vitro; Individual; Infection; Inflammation; Laboratories; Laboratory Procedures; Linear Regressions; Logistic Regressions; Measurement; Measures; Medical Research; Methods; Modeling; Mutation; Normal Statistical Distribution; Outcome; Population; Process; Programming Languages; Proteome; Quality Control; Regression Analysis; Relative (related person); Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Role; Statistical Data Interpretation; Statistical Methods; Statistical Models; Testing; Time; Variant; Vertebral column; Viral; Viral Genes; Viral Proteins; Virus; Work; cost; data management; design; experience; fitness; in vivo; insight; instrument; interest; mutant; novel; programs; quality assurance; research study; theories; tool; transmission process; virology

Statistical and database support for the Seattle Primary Infection Program The need for biostatistics and other quantitative support is part of most medical research and as such, the SeaPIP Projects will utilize the resources of the Biostatistics Core on some level in nearly every type of research conducted. Recent advances in data collection and measurement instruments result in more and more complex data types, such as viral and cellular genomics, viral dynamics, and sophisticated measures of immune responses: all areas that would benefit from input and collaboration with statisticians. By including MSlevel biostatisticians for routine analyses and PhD-level biostatisticians for collaboration on more advanced analyses, the SeaPIP Biostatistics Core is well equipped to handle these complex new problems, in addition to providing standard and necessary classical biostatistics support. In addition, given the diversity of projects requiring Biostatistical support, the Core can provide the infrastructure needed to integrate the disparate statistical and scientific activities of the Program Project as a whole, and identify opportunities for inter-project hypothesis generation and exploratory analyses. The Biostatistics Core will use MS-level SAS programmers and statisticians across all three projects which will provide efficiency and breadth of experience to the Program overall. Furthermore, Drs. Holte and Hughes will have regular interactions to discuss Program statistical activities so that each Project can benefit from statistical scientific insights gained in the analysis from all three Projects in the Program. Finally, the most successful collaborations between statisticians and clinical and laboratory researchers is achieved when the same researchers work together over long periods of time. Dr. Holte has many years of experience in collaborating with the SeaPIP investigators, so that she is well equipped to continue to support the quantitative needs of this scientific program.

为西雅图主要感染计划提供统计和数据库支持 对生物统计学和其他定量支持的需求是大多数医学研究的一部分，因此， SeaPIP 项目将在某种程度上利用生物统计核心的资源，用于几乎所有类型的研究 进行的研究。数据收集和测量仪器的最新进展导致更多和 更复杂的数据类型，例如病毒和细胞基因组学、病毒动力学以及复杂的测量 免疫反应：所有将受益于统计学家的投入和合作的领域。通过包括 MS 级生物统计学家进行常规分析和博士级生物统计学家进行更高级分析的合作，SeaPIP 生物统计学核心除了提供标准和必要的经典生物统计学支持外，还具备充分的能力来处理这些复杂的新问题。 此外，考虑到需要生物统计支持的项目的多样性，核心可以提供 将计划项目的不同统计和科学活动整合为一个整体，并确定项目间假设生成和探索性分析的机会所需的基础设施。生物统计学核心将在所有三个项目中使用 MS 级 SAS 程序员和统计学家，这将为整个计划提供效率和丰富的经验。此外，博士。霍尔特和休斯将定期互动，讨论计划统计活动，以便每个项目都能从该计划所有三个项目的分析中获得的统计科学见解中受益。 最后，当同一研究人员长期合作时，统计学家与临床和实验室研究人员之间最成功的合作才能实现。 Holte 博士拥有多年与 SeaPIP 研究人员合作的经验，因此她有能力继续支持该科学计划的定量需求。