Physiological Characteristics and Data Management

生理特征和数据管理

• 批准号: 7942608
• 负责人: JOSEPH H. SZURSZEWSKI
• 金额: $ 90.8万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7942608
• 关键词: Animal Experimentation; Animal Model; Animals; Archives; Area; Back; Basic Science; Biological Assay; Breath Tests; Characteristics; Clinical Trials; Data; Data Analyses; Data Set; Data Storage and Retrieval; Databases; Electronics; Engineering; Ensure; Equipment; Functional disorder; Gastric Emptying; Gastroparesis; Human Resources; Image; Image Analysis; Individual; Lead; Link; Longitudinal Studies; Measurement; Measures; Molecular; Motor; Mus; Octanoic Acids; Physiological; Physiology; Quality Control; Research; Research Infrastructure; Research Personnel; Secure; Services; Stomach; Structure; Testing; Time; Training; base; data management; data mining; design; flexibility; longitudinal animal study; meetings; novel strategies; novel therapeutic intervention; programs; therapeutic development; tool

The animal management required for, and the vast amount of data generated from integrative longitudinal studies of the pathophysiology of gastric motor function necessitates considerable organization. The Physiological Characterization and Data Management Core C will provide the infrastructure required to support integrative longitudinal animal studies. Central to this infrastructure is a database, the Electronic Animal Research Record (EARR), designed specifically for this Program Project, that will be managed by Core C. EARR will store data for individual mice on secure servers. Stored data will include measurements and analyses directly made by Core C as well as relevant data generated from each Project and analysis of image datasets made by Imaging Core B. Image datasets will be stored on servers maintained in Imaging Core B but will be searchable from within EARR via a data pipeline between servers. All data will be relationally linked to an individual animal's EARR. Data analysis tools were designed specifically to meet the needs of Project investigators and will provide information required for rapid public sharing of the results of studies proposed in this application. Data mining tools developed by Core C and Imaging Core B will allow researchers to compile data from a vast number of animals to perform retrospective analyses. This database will be flexible to meet the evolving needs of the Project investigators. A second function of Core C will be to perform the gastric emptying assays in mice required by the Projects of the Program Project. The centralized organization of this single assay of gastric motor function will make efficient use of the equipment needed by all Projects, standardize the assay and ensure that quality controls are performed. Core C will also provide support for animal model management to the Projects through training and back-up technical service. Collectively, these functions of Core C will facilitate the Projects to reach their respective research aims. All Projects are united in the overall objective to identify molecular mechanisms of gastric motor dysfunction that will lead to clinical trials that test novel therapeutic interventions. The Physiological Characterization and Data Management Core C will help to make sure this objective is reached.

胃运动功能病理生理学的综合纵向研究所产生的大量数据需要大量的组织。生理表征和数据管理核心C将提供支持综合纵向动物研究所需的基础设施。该基础设施的核心是一个数据库，即电子动物研究记录（EARR），专门为该项目设计，将由Core c管理。EARR将在安全服务器上存储单个小鼠的数据。存储的数据将包括测量值