Administrative Core

该计划项目“肠道系统病理学”的更新建立在该计划项目前四年取得的重大进展和成就以及马约诊所在胃肠动力学基础、临床和转化研究方面的丰富经验和卓越成就记录的基础上。该计划项目的重点是糖尿病患者和糖尿病动物模型以及神经性厌食症和神经性贪食症小鼠模型的胃肠道动力失调。它扩展了我们现有的研究组合，包括对这些饮食失调中胃动力障碍的研究，因为厌食症和神经性贪食症中的胃动力障碍和胃排空障碍反映了糖尿病中的胃动力障碍和胃排空障碍。这一更新请求包括神经胃肠病学和生物医学成像科学的新工作人员研究人员。因此，相当大的协调和行政努力是必不可少的管理这一计划。行政核心A：（1）确保所有项目取得足够的进展;（2）监督和协调预算的编制;（3）审查和评估成像核心B和生理表征和数据管理核心C及其资源利用;（4）制定未来计划;（5）管理马约诊所相关行政实体内部和外部的所有问题和沟通;（6）协调行政核心A执行委员会和内部咨询委员会的会议;（7）协调外部咨询委员会的年度会议。该计划项目的实施和管理将通过主要研究者Joseph H. Szurszewski先生通过执行委员会每两个月举行一次正式会议，并在需要时通过电话和电子邮件与之联系。将通过与执行委员会、各项目的项目负责人以及成像核心B主任和生理表征和数据管理核心C主任每两个月举行一次会议，评估科学进展并促进项目与核心之间的合作。审查与内部咨询委员会的会议，并由外部咨询委员会对计划进行年度正式审查。

The renewal of this Program Project "Pathobiology of the Enteric System" builds upon the significant advances and accomplishments achieved during the first four years of this Program Project as well as on the extensive experience and superb record of accomplishments in the basic, clinical and translational research in gastrointestinal motility at the Mayo Clinic. This Program Project focuses on dysregulation of motility of the gastrointestinal tract in patients with diabetes and in animal models of diabetes and in mouse models of anorexia nervosa and bulimia nervosa. It expands our existing research portfolio to include research on gastric dysmotilities in these eating disorders because dysmotilities of the stomach and gastric emptying disorders seen in anorexia and bulimia nervosa mirror those seen in diabetes. This renewal request includes new staff investigators in neurogastroenterology and biomedical imaging sciences. Thus, considerable coordination and administrative effort is essential to manage this program. The Administrative Core A: (1) ensures that adequate progress is made on all projects; (2) supervises and coordinates the preparation of budgets; (3) reviews and evaluates Imaging Core B and Physiological Characterization and Data Management Core C and their resource utilization; (4) develops plans for future initiatives; (5) manages all issues and communications within relevant administrative entities at Mayo Clinic and extramurally; (6) coordinates the meetings of the Executive Committee of Administrative Core A and the Internal Advisory Committee; and (7) coordinates the annual meeting of the External Advisory Committee. Implementation and management of the Program Project will be facilitated through the leadership of the Principal Investigator, Dr. Joseph H. Szurszewski, through the Executive Committee by formal bimonthly meetings, and as needed, by telephone calls and e-mails. Assessment of scientific progress and facilitation of collaboration between the projects and cores will be accomplished through the bimonthly meetings with the Executive Committee and with the Project Leaders of the individual projects and with Directors of Imaging Core B and Physiological Characterization and Data Management Core C, review of the meetings with the Internal Advisory Committee and by annual formal review of the Program by the External Advisory Committee.