Administrative Core

该计划项目“肠道系统的病理生物学”的续期建立在该计划项目的头四年中取得的重大进展和成就的基础上，以及梅奥诊所在胃肠动力基础、临床和翻译研究方面的广泛经验和卓越记录。该项目的重点是糖尿病患者和糖尿病动物模型以及神经性厌食症和神经性暴食症的小鼠模型中胃肠道运动的失调。它扩大了我们现有的研究组合，将这些饮食障碍中的胃动力障碍的研究包括在内，因为胃动力障碍和胃排空障碍在厌食症和神经性暴食症中可以看到，反映了糖尿病的情况。这一续签请求包括神经胃肠病学和生物医学成像科学方面的新工作人员。因此，相当大的协调和管理努力对管理这一计划至关重要。行政核心A：(1)确保在所有项目上取得适当进展；(2)监督和协调预算的编制；(3)审查和评价成像核心B和生理特征以及数据管理核心C及其资源利用情况；(4)为未来举措制定计划；(5)管理梅奥诊所相关行政实体内部和外部的所有问题和沟通；(6)协调行政核心A执行委员会和内部咨询委员会的会议；(7)协调外部咨询委员会的年度会议。将通过首席调查员Joseph H.Szurszewski博士的领导，通过执行委员会每两个月举行一次正式会议，并视需要通过电话和电子邮件促进方案项目的实施和管理。对科学进展的评估和促进项目与核心之间的合作将通过与执行委员会、个别项目的项目负责人以及成像核心B和生理特征和数据管理核心C的主任举行的双月会议、与内部咨询委员会的会议审查以及外部咨询委员会对计划的年度正式审查来完成。

The renewal of this Program Project "Pathobiology of the Enteric System" builds upon the significant advances and accomplishments achieved during the first four years of this Program Project as well as on the extensive experience and superb record of accomplishments in the basic, clinical and translational research in gastrointestinal motility at the Mayo Clinic. This Program Project focuses on dysregulation of motility of the gastrointestinal tract in patients with diabetes and in animal models of diabetes and in mouse models of anorexia nervosa and bulimia nervosa. It expands our existing research portfolio to include research on gastric dysmotilities in these eating disorders because dysmotilities of the stomach and gastric emptying disorders seen in anorexia and bulimia nervosa mirror those seen in diabetes. This renewal request includes new staff investigators in neurogastroenterology and biomedical imaging sciences. Thus, considerable coordination and administrative effort is essential to manage this program. The Administrative Core A: (1) ensures that adequate progress is made on all projects; (2) supervises and coordinates the preparation of budgets; (3) reviews and evaluates Imaging Core B and Physiological Characterization and Data Management Core C and their resource utilization; (4) develops plans for future initiatives; (5) manages all issues and communications within relevant administrative entities at Mayo Clinic and extramurally; (6) coordinates the meetings of the Executive Committee of Administrative Core A and the Internal Advisory Committee; and (7) coordinates the annual meeting of the External Advisory Committee. Implementation and management of the Program Project will be facilitated through the leadership of the Principal Investigator, Dr. Joseph H. Szurszewski, through the Executive Committee by formal bimonthly meetings, and as needed, by telephone calls and e-mails. Assessment of scientific progress and facilitation of collaboration between the projects and cores will be accomplished through the bimonthly meetings with the Executive Committee and with the Project Leaders of the individual projects and with Directors of Imaging Core B and Physiological Characterization and Data Management Core C, review of the meetings with the Internal Advisory Committee and by annual formal review of the Program by the External Advisory Committee.