Kansas IDeA Network of Biomedical Research Excellence

描述（由申请人提供）：堪萨斯大学医学中心 (KUMC) 在此提出一份继续支持堪萨斯 IDeA 生物医学研究卓越网络 (K-INBRE) 的申请。 K-INBRE 将 KUMC（牵头机构）与堪萨斯州另外两所主要的博士学位授予机构（堪萨斯劳伦斯大学，KU-L；堪萨斯州立大学，KSU）作为研究生合作机构 (GPI) 以及七个本科合作机构 (UPI) 联系起来。 UPI 包括堪萨斯州的六个本科校区（恩波里亚州立大学、海斯堡州立大学、哈斯克尔印第安民族大学、匹兹堡州立大学、沃什伯恩大学、威奇托州立大学）和兰斯顿大学（俄克拉何马州兰斯顿）。哈斯克尔印第安民族大学和兰斯顿大学增加了网络的多样性，第一所大学致力于美国原住民的教育和培训，第二所大学主要招收黑人本科生。堪萨斯州计划的长期目标是通过当前 K-INBRE 的成功，加强该州在细胞和发育生物学方面的研究能力。 K-INBRE 的规模、结构和运作原则是在前几年的支持期间确定的，其中包括高度重视生物医学研究、网络和校园间交流的培训以及建立复杂的生物信息学项目。这些目标基本保持不变，因为 K-INBRE 对堪萨斯州的生物医学研究产生了重大积极影响。 K-INBRE 实施的项目在实现其既定目标以及 NCRR IDeA 项目的目标方面取得了显着的成功。 K-INBRE下一阶段提出的具体目标是（1）以高效管理和注重网络的方式维护和改善当前细胞和发育生物学的多学科研究网络，（2）通过提供先进的生物信息学技术和教育来增强科学技术知识和整合，（3）通过基础和临床科学家培训机会的双向交流促进转化研究。在这些目标中，改进 K-INBRE 的新功能包括扩大对研究职业的资助以及改进监督和指导过程，在我们的生物信息学网络中推广综合系统生物学方法，以及将转化研究培训纳入 K-INBRE 目标，以便科学发现顺利进入临床领域。 公共卫生相关性（由申请人提供）：细胞和发育生物学的研究对于增进我们对健康和疾病的细胞过程的理解至关重要。此类研究依赖于培养一支强大的、受过良好教育的劳动力队伍、随时可用的发现工具以及强调将发现研究的结果应用于人类健康问题。为了在堪萨斯州建立一个杰出的细胞和发育生物学研究中心，K-INBRE 积极推行所有这三个关键战略。

DESCRIPTION (provided by applicant): The University of Kansas Medical Center (KUMC) here presents an application for continued support for the Kansas IDeA Network for Biomedical Research Excellence (K-INBRE). The K-INBRE links KUMC (Lead Institution) with the two other major doctoral-degree-granting institutions in Kansas (University of Kansas-Lawrence, KU-L; Kansas State University, KSU) as Graduate Partner Institutions (GPI) and with seven Undergraduate Partner Institutions (UPI). UPI include six Kansas undergraduate campuses (Emporia State University, Ft. Hays State University, Haskell Indian Nations University, Pittsburgh State University, Washburn University, Wichita State University) and Langston University (Langston, OK). Haskell Indian Nations University and Langston University increase diversity in the network as the first is devoted to education and training of native Americans and the second enrolls primarily black undergraduates. The long-range objective of the Kansas program is to strengthen the state's research capacity in Cell and Developmental Biology by building on the successes of the current K-INBRE. The size, structure and operational principles of the K-INBRE, which include strong emphasis on training for biomedical research, networking and intercampus communication and the establishment of a sophisticated bioinformatics program, were established during the previous years of support. These goals remain basically the same as the K-INBRE has had a major positive impact on biomedical research in the State of Kansas. Programs conducted by the K-INBRE have had measurable success in reaching their stated goals as well as those of the NCRR IDeA program. The Specific Aims proposed for the next phase of the K-INBRE are to (1) maintain and improve the current multi-disciplinary research network in Cell and Developmental Biology with efficient administration and focus on networking, (2) enhance science and technology knowledge and integration by offering sophisticated bioinformatics technology and education, (3) facilitate translational research via bidirectional exchange of basic and clinical scientist training opportunities. Within these Aims, new features that improve the K-INBRE include broadening funding for research careers together with improvements in oversight and the mentoring process, promoting an integrated systems biology approach within our bioinformatics network, and incorporating training for translational research into the K-INBRE goals so as to smooth the progress of scientific discoveries into the clinical arena. PUBLIC HEALTH RELEVANCE (provided by applicant): Research in cell and developmental biology is essential to advancing our understanding of cellular processes of health and disease. Such research relies on generation of a strong, well educated workforce, ready availability of the tools of discovery and emphasis on applying the results of discovery research to problems of human health. In building a distinguished center of research in cell and developmental biology in Kansas, the K-INBRE vigorously pursues all three of these key strategies.