Nathan Shock Ctr of Excellence in Basic Biology of Aging

描述（由申请人提供）：本申请是华盛顿大学衰老基础生物学卓越中心的续期申请。在过去的10年里，该中心为研究该地区衰老基础生物学的大型研究人员提供了资源支持。我们提供广泛的外部资助，同行评审的研究项目，从中心到个人研究者资助。我们的更新建议的组成部分包括一个资源核心，其中包括3个组成部分：1)转基因动物模型开发资源核心；2)细胞术资源核心；3)功能基因组学资源核心。在下一个资助期，转基因动物模型开发资源中心将致力于开发和应用转基因的发育和外源调控结构。我们将继续我们的理念，帮助大量研究人员开发用于衰老研究的小鼠模型。除了流式细胞术和细胞分选外，该中心还将提供共聚焦显微镜和激光捕获显微解剖服务。功能基因组学核心是我们基因表达核心的进化，将为转录组学，蛋白质组学和代谢组学提供专家协助。研究发展核心将继续支持老化基础生物学的试点研究项目。计划浓缩核心支持行政管理、外部顾问小组以及课程和研讨会计划。

DESCRIPTION (provided by applicant): This application is for renewal of the Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington. This Center has over the past 10 years provided resources in support of the large community of investigators that study the basic biology of aging in this region. We serve a broad spectrum of externally funded, peer-reviewed research programs, ranging from Centers to individual investigator grants. Proposed components of our renewal include a Resources Core with 3 components: 1) Transgenic Animal Model Development Resource Core; 2) Cytometry Resource Core; 3) Functional Genomics Resource Core. In this next funding period, the Transgenic Animal Model Development Resource Core will work to develop and apply constructs for developmental and exogenous regulation of transgenes. We will continue our philosophy of helping a large number of investigators to develop mouse models for aging studies. The Cytometry Core will provide confocal microscopy and laser capture microdissection services in addition to flow cytometry and cell sorting. The Functional Genomics Core is the evolution of our Gene Expression core and will provide expert assistance for transcriptomics, proteomics and metabolomics. The Research Development Core will continue to support pilot study projects in the basic biology of aging. The Program Enrichment Core supports administrative management, an external advisory panel, and a program of courses and seminars.