The development of mass spectrometry for Clinical Glycomics
临床糖组学质谱分析的发展
基本信息
- 批准号:7935886
- 负责人:
- 金额:$ 16.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-30 至 2010-12-31
- 项目状态:已结题
- 来源:
- 关键词:BioinformaticsBiologicalCarbonCarbon DioxideCellsChromatographyClinicClinicalComplementComputer softwareDevelopmentDiagnosisDiseaseDisease MarkerDissociationEye diseasesFoundationsFucoseFutureGlycoproteinsHarvestHeterogeneityHumanIndividualInvestigationLasersLinkLiquid substanceMalignant NeoplasmsMalignant neoplasm of ovaryMalignant neoplasm of prostateMarker DiscoveryMass Spectrum AnalysisMethodsOcular RosaceaOligosaccharidesOutcome StudyPolysaccharidesProcessProteinsProteomeResearchResearch PersonnelSerumSialic AcidsSiteSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationStructureTimeanalytical toolbaseeye drynessglycosylationinnovationinstrumentmalignant breast neoplasmneglectprogramstool
项目摘要
DESCRIPTION (provided by applicant): We will develop the methods and tools that will profile glycans in human fluids to enable the discovery of markers for diseases. Cancer is a disease known to accompany aberrant glycosylation. Glycoproteins shed by diseased cells will be harvested for their glycan content and profiled to obtain disease markers. This approach represents a new paradigm for disease marker discovery. It will focus primarily on the glycans as disease markers while neglecting, at first, the identity of the associated proteins. This approach will be multifaceted and primarily glycocentric; it contrasts and complements the proteome-centered approaches currently under extensive investigations. In this process, we will develop a set of mass spectrometry-based tools for clinical glycomics. These tools will be used to observe changes in glycosylation of diseases in two human fluids, sera and tear. The fluids are chosen by the needs of our collaborator in diseases that include ovarian cancer and ocular rosacea but will have direct implications in breast cancer and prostate cancer for sera and other dry eye diseases for tear fluids. While disease markers will be the future outcome of these studies, they will not be the only focus of this project. Instead we will also develop the tools that will be used by our collaborators to discover markers for these diseases and lay the foundation for the use of mass spectrometry in clinics for glycomic analyses.
描述(由申请人提供):我们将开发方法和工具,用于分析人体体液中的聚糖,以发现疾病标志物。癌症是已知伴随异常糖基化的疾病。将收获病变细胞脱落的糖蛋白的聚糖含量,并分析以获得疾病标志物。这种方法代表了疾病标志物发现的新范式。它将主要集中在作为疾病标志物的聚糖上,而首先忽略了相关蛋白质的身份。这种方法将是多方面的,主要是以糖为中心的;它对比和补充了目前正在广泛研究的以蛋白质组为中心的方法。在这个过程中,我们将开发一套基于质谱的临床糖组学工具。这些工具将用于观察两种体液(血清和泪液)中疾病糖基化的变化。这些液体是根据我们的合作者在包括卵巢癌和眼红斑痤疮在内的疾病中的需求而选择的,但对乳腺癌和前列腺癌的血清和其他干眼症的泪液有直接影响。虽然疾病标志物将是这些研究的未来成果,但它们不会是该项目的唯一重点。相反,我们还将开发工具,供我们的合作者用于发现这些疾病的标志物,并为在临床上使用质谱法进行糖组学分析奠定基础。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CARLITO B LEBRILLA其他文献
CARLITO B LEBRILLA的其他文献
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{{ truncateString('CARLITO B LEBRILLA', 18)}}的其他基金
Annotating carbohydrate structures to develop markers for consumption of food
注释碳水化合物结构以开发食物消耗标记
- 批准号:
10543847 - 财政年份:2020
- 资助金额:
$ 16.75万 - 项目类别:
Annotating carbohydrate structures to develop markers for consumption of food
注释碳水化合物结构以开发食物消耗标记
- 批准号:
10133066 - 财政年份:2020
- 资助金额:
$ 16.75万 - 项目类别:
Annotating carbohydrate structures to develop markers for consumption of food
注释碳水化合物结构以开发食物消耗标记
- 批准号:
10312118 - 财政年份:2020
- 资助金额:
$ 16.75万 - 项目类别:
Glycomics Equipment: NanoLC CHIP-QTOF Mass Spectrometer
糖组学设备:NanoLC CHIP-QTOF 质谱仪
- 批准号:
7794794 - 财政年份:2010
- 资助金额:
$ 16.75万 - 项目类别:
Structures, Functions, & Genetic Diversity of Oligosaccharides in Milk
结构、功能、
- 批准号:
8487419 - 财政年份:2009
- 资助金额:
$ 16.75万 - 项目类别:
Structures, Functions, & Genetic Diversity of Oligosaccharides in Milk
结构、功能、
- 批准号:
8305556 - 财政年份:2009
- 资助金额:
$ 16.75万 - 项目类别:
Structures, Functions, & Genetic Diversity of Oligosaccharides in Milk
结构、功能、
- 批准号:
7739537 - 财政年份:2009
- 资助金额:
$ 16.75万 - 项目类别:
Structures, Functions, & Genetic Diversity of Oligosaccharides in Milk
结构、功能、
- 批准号:
8096559 - 财政年份:2009
- 资助金额:
$ 16.75万 - 项目类别:
Structures, Functions, & Genetic Diversity of Oligosaccharides in Milk
结构、功能、
- 批准号:
7931910 - 财政年份:2009
- 资助金额:
$ 16.75万 - 项目类别:
Necrotizing Enterocolitis: Prevention and Prediction
坏死性小肠结肠炎:预防和预测
- 批准号:
7933176 - 财政年份:2009
- 资助金额:
$ 16.75万 - 项目类别:
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