Artemis: Biochemical ,structural and functional analysis

Artemis：生化、结构和功能分析

• 批准号: 7896656
• 负责人: PATRICIA CORTES
• 金额: $ 42.05万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-21 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7896656
• 关键词: Affect; Antigen Receptors; B-Lymphocytes; Biochemical; Biochemistry; C-terminal; Cell Line; Cells; Chromosome abnormality; Cleaved cell; Code; Complement; Complex; DNA; DNA Binding; DNA Repair; DNA Repair Pathway; Defect; Gene Proteins; Genes; Genetic Recombination; Genome Stability; Goals; Human; Immunologic Deficiency Syndromes; In Vitro; Joints; Kinetics; Knockout Mice; Knowledge; Ligase; Ligation; Light; Lymphocyte; Maintenance; Molecular; Mutation; Nature; Nonhomologous DNA End Joining; Pathway interactions; Peptide Signal Sequences; Phenotype; Principal Investigator; Process; Property; Proteins; Radiation Tolerance; Receptor Gene; Repair Complex; Reporting; Role; Solutions; Structure; Structure-Activity Relationship; Syndrome; Tertiary Protein Structure; V(D)J Recombination; Work; X-Ray Crystallography; abstracting; artemis; base; dimer; in vivo; mutant; novel; nuclease; programs; protein structure; repaired; research study

Program Director/Principal Investigator (Last, First, Middle): Cortes, Patricia 1R01 AI070532-01A2 ABSTRACT

项目负责人/主要研究者（最后一名、第一名、中间名）：科尔特斯、Patricia 1 R 01 AI 070532 - 01 A2 摘要

项目成果

The DNA binding domain and the C-terminal region of DNA Ligase IV specify its role in V(D)J recombination.

• DOI: 10.1371/journal.pone.0282236
• 发表时间: 2023
• 期刊: PloS one
• 影响因子: 3.7

Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining.

• DOI: 10.1016/j.celrep.2012.11.004
• 发表时间: 2012-12-27
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: De Ioannes P;Malu S;Cortes P;Aggarwal AK
• 通讯作者: Aggarwal AK