Pharmacokinetics (Florida)

药代动力学（佛罗里达）

• 批准号: 7945398
• 负责人: Michael Darin Cameron
• 金额: $ 32.05万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7945398
• 关键词: Animals; Arts; Biological Assay; Cells; Chemicals; Containment; Contracts; Drug Interactions; Drug Kinetics; Drug Stability; Florida; Housing; In Vitro; Jupiter; Laboratories; Measures; Metabolic; Mus; Permeability; Procedures; Protein Binding; Quarantine; Rattus; Rodent; Services; Technology; Training; Veterinarians; in vitro Assay; in vivo; research facility; square foot

DMPK CORE The DMPK core provides enabling technologies and capabilities to support the discovery of new chemical entities, ranging from in vitro ADMET assays to in vivo pharmacokinetics in rats and mice. In vitro assays include measures for cell permeability, protein binding, metabolic stability, and drug-drug interaction liabilities. The DMPK group at Scripps Florida currently occupies approximately 1000 sq/ft of laboratory and the office space housed in a 41,000 sq/ft research facility in Jupiter, Florida. Animal services are provided in a new stateof- the-art facility of approximately 5,000 square feet with the capacity to house approximately 1500 mouse and 240 rat cages. The Vivarium includes animal quarantine and holding rooms for rodents, dedicated procedure space, and a biosafety level 3 (BSL3) containment suite with shower-in requirement, biosafety cabinets, ventilated racks, and pass-through autoclave. Animal services are provided by a fully trained staff with a contract veterinarian.

DMPK核心 DMPK核心提供使能技术和能力，以支持新化学物质的发现 从体外ADMET试验到大鼠和小鼠的体内药代动力学。体外试验 包括细胞通透性、蛋白质结合、代谢稳定性和药物-药物相互作用责任的衡量标准。 位于佛罗里达州斯克里普斯的DMPK团队目前占据了大约1000平方英尺的实验室和办公室 空间位于佛罗里达州朱庇特的一个4.1万平方英尺的研究设施中。动物服务是在新的状态下提供的- 先进的设施占地约5,000平方英尺，可容纳约1500只鼠标和 240个鼠笼。隔室包括动物检疫和啮齿动物拘留室，专门的程序 空间，以及带淋浴要求的生物安全3级(BSL3)遏制套房、生物安全柜、 通风机架和直通式高压灭菌器。动物服务由训练有素的工作人员提供，并配备 签约兽医。