Perinatal Depression and Maternal Nutritional Status

描述（由申请人提供）：围产期抑郁症有严重的不良影响，包括损害母亲和儿童的营养状况。营养不良也可能影响抑郁症状。这项提案的目标是为Lisa Bodnar医生提供她所需的心理健康培训，使她成为一名围产期心理健康的独立调查员和营养干预学家。博德纳博士是围产学领域的营养流行病学家。她对围产期精神病学营养方面的兴趣是她以前工作的自然延伸。她的短期目标是：(1)获得对神经生物学、精神病学和用于评估心理健康结果的方法学方法的清晰理解；(2)为女性情绪障碍的诊断和治疗反应评价积累实践经验；(3)获取试点数据，为R01拨款申请提供严谨的方法方案，以开展一项大型前瞻性研究，研究围产期情绪障碍的营养因素及其后果。她将通过一个培训计划来实现这些目标，该计划包括指导、课程、临床实习、研讨会、指导阅读、手稿写作和负责任的研究行为培训。匹兹堡大学流行病学和精神病学院系的机构支持将培养她的能力，培养她成功竞争研究经费所需的技能。支持这些目标的项目将使用一项自然的纵向研究（R01 MH60335; KL Wisner， PI）的数据，研究怀孕期间抑郁症和抗抑郁药物使用的后果：(1)描述抑郁症妇女的围产期营养状况，接受抗抑郁药物治疗的妇女及其后代；(2)更好地了解怀孕期间和产后营养状况和体重对抑郁症状的相互作用；(3)阐明营养在抑郁症病理生理中的作用。

DESCRIPTION (provided by applicant): Perinatal depression has serious adverse effects, including harming the nutritional status of mothers and children. Depressive symptoms may also be affected by poor nutrition. The goal of this proposal is to provide Dr. Lisa Bodnar with the mental health training she needs to become an independent investigator and nutritional interventionist in perinatal mental health. Dr. Bodnar is a nutritional epidemiologist in the area of perinatology. Her interest in nutritional aspects of perinatal psychiatry represents a natural extension of her previous work. Her short-term goals are: (1) to acquire a clear understanding of neurobiology, psychiatry, and methodological approaches used to assess mental health outcomes; (2) to gain practical experience in the diagnosis and evaluation of treatment response of mood disorders in women; and (3) to obtain pilot data to inform a methodologically rigorous protocol for an R01 grant application to conduct a large prospective study of the nutritional contributors to and consequences of perinatal mood disorders. She will achieve these goals through a training plan that incorporates mentoring, coursework, a clinical practicum, seminars, directed readings, manuscript writing, and training in the responsible conduct of research. The institutional support of the epidemiology and psychiatry departments at the University of Pittsburgh will foster her ability to develop the skills necessary to successfully compete for research funding. The project to support these goals will use data from a naturalistic, longitudinal study (R01 MH60335; KL Wisner, PI) of the consequences of depression and antidepressant use during pregnancy to: (1) characterize the perinatal nutritional status of women with depression women treated with antidepressants for depression, and their offspring, (2) gain a greater understanding of the interaction of nutritional status and body weight during pregnancy and postpartum on depressive symptoms; and (3) elucidate the role of nutrition in the pathophysiology of depression.