Motor Proficiency and Physical Activity in Adult Survivors of Childhood ALL

描述（由申请人提供）：被诊断患有急性淋巴细胞白血病（ALL）的儿童的五年存活率接近90%，这使得对其长期疾病和治疗相关结果的检查成为一个重大的公共卫生问题。儿童ALL幸存者的早期死亡率，第二恶性肿瘤，肥胖和心脏病的风险增加，通常不可避免，因为癌症的影响或治愈所需的治疗。长期结果也受到生活方式选择的影响，并且可能在身体残疾阻止参与常规体力活动的所有幸存者中加剧。本申请的主要目标是提供关于一大群儿童ALL幸存者的肌肉骨骼健康、感觉功能和健康受损的全面客观信息，并通过评估导致功能受损的治疗因素来定义高危人群。此外，评估这些损伤对参与定期身体活动的影响，将允许设计干预措施，考虑到普遍的功能丧失，并改善儿童ALL幸存者参与定期身体活动的机会，这些幸存者的健康选择受到长期残疾的影响。我们建议进行一项研究，包括直接，客观的评估肌肉骨骼功能，感觉能力，健身和身体活动模式的成年人谁是治疗儿童ALL在圣裘德儿童研究医院1980年至1998年。在899名ALL幸存者中，所有这些人都有资格参加一项由机构资助的医学迟发效应临床研究，我们建议招募364人参加我们的评估。我们还建议招募364名个体作为对照组，根据人种/种族、年龄和性别进行频率匹配。公共卫生相关性：与儿童ALL成年幸存者互动并对其进行治疗的个人将受益于有关疾病和相关治疗药物的重要后果的信息，以便他们能够识别身体表现受限的潜在预测因素。这将允许设计干预措施，以改善身体活动的限制，并有针对性的干预措施，为那些最有可能发展随后限制他们参与促进健康生活方式的活动的人。

DESCRIPTION (provided by applicant): Five year survival rates for children diagnosed with acute lymphoblastic leukemia (ALL) are nearing 90%, making examination of their long-term disease and treatment related outcomes a substantial public health concern. Childhood ALL survivors are at increased risk for early mortality, second malignancies, obesity and heart disease, often unavoidable because of either the effects of the cancer or the treatment required for cure. Long-term outcomes are also influenced by lifestyle choices, and may be exacerbated in ALL survivors whose physical disabilities prevent participation in regular physical activity. The primary goal of this application is to provide comprehensive and objective information on impairments of musculoskeletal health, sensory function, and fitness among a large group of childhood ALL survivors, and to define high risk groups by assessing treatment factors that contribute to impaired function. In addition, an evaluation of the impact of these impairments on participation in regular physical activity will allow for the design of interventions that take into account prevalent functional loss, and improve opportunities for participation in regular physical activity among childhood ALL survivors whose health choices are compromised by long-term disability. We propose to conduct a study that includes a direct, objective evaluation of musculoskeletal function, sensory capacity, fitness and physical activity patterns among adults who were treated for childhood ALL at St. Jude Children's Research Hospital between 1980 and 1998. Among 899 ALL survivors, all of whom are eligible for an institutionally funded clinical study of medical late effects, we propose to recruit 364 to participate in our evaluations. We also propose to recruit 364 individuals for a comparison group, frequency matching on race/ethnicity, age and gender. PUBLIC HEALTH RELEVANCE: Individuals who interact with and treat adult survivors of childhood ALL will benefit from information about the important consequences of disease and associated treatment agents so that they can recognize potential predictors of limited physical performance. This will allow for the design of interventions to ameliorate physical activity limitations, and targeted interventions for those individuals who are at greatest risk for developing subsequent restrictions in their abilities to participate in activities that promote a healthy lifestyle.