Motor Proficiency and Physical Activity in Adult Survivors of Childhood ALL

儿童期急性淋巴细胞白血病成年幸存者的运动能力和体力活动

基本信息

批准号：
7656171
负责人：
Kirsten Kimberlie Ness
金额：
$ 67.73万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-01 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7656171
关键词：
12 year old Accounting Acute Lymphocytic Leukemia Adult Age Anthracyclines Child Childhood Acute Lymphocytic Leukemia Clinical Research Control Groups Cranial Irradiation Dexamethasone Diagnosis Disease Energy Metabolism Ethnic Origin Evaluation Female Frequencies Funding Gender Glucocorticoids Goals Health Heart Diseases High Prevalence Impact evaluation Impairment Individual Intervention Label Late Effects Life Style Malignant Neoplasms Measures Medical Methotrexate Monitor Motor Muscle Weakness Musculoskeletal Obesity Outcome Participant Pattern Performance Peripheral Nervous System Diseases Physical activity Prednisone Prevalence Public Health Race Recruitment Activity Reporting Risk Saint Jude Children&apos s Research Hospital Second Primary Neoplasms Sensory Survival Rate Survivors Techniques Treatment Factor Vincristine Water comparison group disability fitness functional loss high risk improved member mortality muscle form prevent public health relevance therapy design

项目摘要

DESCRIPTION (provided by applicant): Five year survival rates for children diagnosed with acute lymphoblastic leukemia (ALL) are nearing 90%, making examination of their long-term disease and treatment related outcomes a substantial public health concern. Childhood ALL survivors are at increased risk for early mortality, second malignancies, obesity and heart disease, often unavoidable because of either the effects of the cancer or the treatment required for cure. Long-term outcomes are also influenced by lifestyle choices, and may be exacerbated in ALL survivors whose physical disabilities prevent participation in regular physical activity. The primary goal of this application is to provide comprehensive and objective information on impairments of musculoskeletal health, sensory function, and fitness among a large group of childhood ALL survivors, and to define high risk groups by assessing treatment factors that contribute to impaired function. In addition, an evaluation of the impact of these impairments on participation in regular physical activity will allow for the design of interventions that take into account prevalent functional loss, and improve opportunities for participation in regular physical activity among childhood ALL survivors whose health choices are compromised by long-term disability. We propose to conduct a study that includes a direct, objective evaluation of musculoskeletal function, sensory capacity, fitness and physical activity patterns among adults who were treated for childhood ALL at St. Jude Children's Research Hospital between 1980 and 1998. Among 899 ALL survivors, all of whom are eligible for an institutionally funded clinical study of medical late effects, we propose to recruit 364 to participate in our evaluations. We also propose to recruit 364 individuals for a comparison group, frequency matching on race/ethnicity, age and gender. PUBLIC HEALTH RELEVANCE: Individuals who interact with and treat adult survivors of childhood ALL will benefit from information about the important consequences of disease and associated treatment agents so that they can recognize potential predictors of limited physical performance. This will allow for the design of interventions to ameliorate physical activity limitations, and targeted interventions for those individuals who are at greatest risk for developing subsequent restrictions in their abilities to participate in activities that promote a healthy lifestyle.

描述（由申请人提供）：诊断出患有急性淋巴细胞白血病（ALL）的儿童的五年生存率接近90％，这使得对其长期疾病和治疗相关的结果的检查引起了极大的公共卫生关注。儿童时期所有幸存者都有早期死亡率，第二次恶性肿瘤，肥胖和心脏病的风险增加，这通常是由于癌症的影响或治愈所需的治疗而不可避免的。长期结局也受到生活方式选择的影响，并且在所有身体残疾阻止常规身体活动的幸存者中可能会加剧。该应用的主要目的是提供有关大量童年的肌肉骨骼健康，感觉功能和适应性的损害的全面和客观信息，所有幸存者都通过评估有助于功能受损的治疗因素来定义高风险组。此外，评估这些障碍对参与常规体育锻炼的影响将允许设计干预措施，这些干预措施考虑到普遍的功能损失，并改善了在儿童时期常规体育锻炼的机会，所有健康选择都会因长期残疾而损害其健康选择。我们建议进行一项研究，其中包括对肌肉骨骼功能，感觉能力，适应性和身体活动模式的直接评估，他们在1980年至1998年之间在圣裘德儿童研究医院接受过童年治疗的成年人中。在899名所有幸存者中，所有幸存者都可以对医疗效果进行机构资助的临床研究，以招募364年，他们都可以对他们进行机构资助的临床研究。我们还建议招募364个人进行比较组，种族/民族，年龄和性别的频率匹配。公共卫生相关性：与童年互动和治疗成年幸存者互动和治疗的个人都将受益于有关疾病和相关治疗剂的重要后果的信息，以便他们可以识别出有限的身体性能的潜在预测指标。这将允许设计干预措施，以减轻体育活动的限制，并为那些面临最大风险的人的针对性干预措施，以制定随后的限制，以促进促进健康生活方式的活动。