Motor Proficiency and Physical Activity in Adult Survivors of Childhood ALL

儿童期急性淋巴细胞白血病成年幸存者的运动能力和体力活动

• 批准号: 7656171
• 负责人: Kirsten Kimberlie Ness
• 金额: $ 67.73万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7656171
• 关键词: 12 year old; Accounting; Acute Lymphocytic Leukemia; Adult; Age; Anthracyclines; Child; Childhood Acute Lymphocytic Leukemia; Clinical Research; Control Groups; Cranial Irradiation; Dexamethasone; Diagnosis; Disease; Energy Metabolism; Ethnic Origin; Evaluation; Female; Frequencies; Funding; Gender; Glucocorticoids; Goals; Health; Heart Diseases; High Prevalence; Impact evaluation; Impairment; Individual; Intervention; Label; Late Effects; Life Style; Malignant Neoplasms; Measures; Medical; Methotrexate; Monitor; Motor; Muscle Weakness; Musculoskeletal; Obesity; Outcome; Participant; Pattern; Performance; Peripheral Nervous System Diseases; Physical activity; Prednisone; Prevalence; Public Health; Race; Recruitment Activity; Reporting; Risk; Saint Jude Children' s Research Hospital; Second Primary Neoplasms; Sensory; Survival Rate; Survivors; Techniques; Treatment Factor; Vincristine; Water; comparison group; disability; fitness; functional loss; high risk; improved; member; mortality; muscle form; prevent; public health relevance; therapy design

DESCRIPTION (provided by applicant): Five year survival rates for children diagnosed with acute lymphoblastic leukemia (ALL) are nearing 90%, making examination of their long-term disease and treatment related outcomes a substantial public health concern. Childhood ALL survivors are at increased risk for early mortality, second malignancies, obesity and heart disease, often unavoidable because of either the effects of the cancer or the treatment required for cure. Long-term outcomes are also influenced by lifestyle choices, and may be exacerbated in ALL survivors whose physical disabilities prevent participation in regular physical activity. The primary goal of this application is to provide comprehensive and objective information on impairments of musculoskeletal health, sensory function, and fitness among a large group of childhood ALL survivors, and to define high risk groups by assessing treatment factors that contribute to impaired function. In addition, an evaluation of the impact of these impairments on participation in regular physical activity will allow for the design of interventions that take into account prevalent functional loss, and improve opportunities for participation in regular physical activity among childhood ALL survivors whose health choices are compromised by long-term disability. We propose to conduct a study that includes a direct, objective evaluation of musculoskeletal function, sensory capacity, fitness and physical activity patterns among adults who were treated for childhood ALL at St. Jude Children's Research Hospital between 1980 and 1998. Among 899 ALL survivors, all of whom are eligible for an institutionally funded clinical study of medical late effects, we propose to recruit 364 to participate in our evaluations. We also propose to recruit 364 individuals for a comparison group, frequency matching on race/ethnicity, age and gender. PUBLIC HEALTH RELEVANCE: Individuals who interact with and treat adult survivors of childhood ALL will benefit from information about the important consequences of disease and associated treatment agents so that they can recognize potential predictors of limited physical performance. This will allow for the design of interventions to ameliorate physical activity limitations, and targeted interventions for those individuals who are at greatest risk for developing subsequent restrictions in their abilities to participate in activities that promote a healthy lifestyle.

描述（由申请人提供）：被诊断患有急性淋巴细胞白血病 (ALL) 的儿童的五年生存率接近 90%，这使得对其长期疾病和治疗相关结果的检查成为重大的公共卫生问题。儿童期 ALL 幸存者的早期死亡、第二恶性肿瘤、肥胖和心脏病的风险增加，由于癌症的影响或治愈所需的治疗，这些疾病通常是不可避免的。长期结果也受到生活方式选择的影响，并且对于所有因身体残疾而无法参加定期体育活动的幸存者来说，长期结果可能会加剧。该应用程序的主要目标是提供有关一大群儿童 ALL 幸存者的肌肉骨骼健康、感觉功能和健康受损的全面、客观的信息，并通过评估导致功能受损的治疗因素来定义高风险群体。此外，评估这些损伤对参与定期体育活动的影响将有助于设计考虑到普遍功能丧失的干预措施，并改善健康选择因长期残疾而受到影响的儿童ALL幸存者参与定期体育活动的机会。我们提议开展一项研究，其中包括对 1980 年至 1998 年间在圣裘德儿童研究医院接受儿童 ALL 治疗的成年人的肌肉骨骼功能、感觉能力、健康和身体活动模式进行直接、客观的评估。在 899 名 ALL 幸存者中，他们都有资格参加机构资助的医学后期影响临床研究，我们建议招募 364 人参与我们的评估。我们还建议招募 364 人作为对照组，对种族/民族、年龄和性别进行频率匹配。公共卫生相关性：与儿童 ALL 成年幸存者互动并对其进行治疗的个人将受益于有关疾病和相关治疗药物的重要后果的信息，以便他们能够识别有限身体表现的潜在预测因素。这将有助于设计改善身体活动限制的干预措施，并针对那些最有可能在参与促进健康生活方式的活动的能力方面受到后续限制的个人进行有针对性的干预措施。