Web-based Physical Activity Intervention for Children with ALL

针对 ALL 儿童的基于网络的身体活动干预

• 批准号: 9298607
• 负责人: Kirsten Kimberlie Ness
• 金额: $ 86.99万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9298607
• 关键词: Accelerometer; Acute Disease; Acute Lymphocytic Leukemia; Adolescent; Adopted; Aftercare; Biological Markers; Body mass index; Bone Density; Cardiomyopathies; Child; Childhood Acute Lymphocytic Leukemia; Childhood Leukemia; Complement; Computer software; Computers; Control Groups; Data; Diagnosis; Educational Materials; Effectiveness; Enrollment; Evaluation; Fasting; Fatigue; Future; Gifts; Glucose; Goals; Health; Height; Individual; Inflammation; Inflammatory; Insulin; Intervention; Late Effects; Lipids; Literature; Measures; Mediating; Modeling; Modification; Neuropathy; Online Systems; Only Child; Participant; Pediatric Oncology Group; Peripheral Nervous System Diseases; Physical activity; Physiological; Pilot Projects; Population; Protocols documentation; Quality of life; Randomized; Recruitment Activity; Reporting; Research; Research Infrastructure; Resources; Rewards; Sampling; Schools; Site; Survival Rate; Survivors; System; Testing; Therapeutic; Time; Video Games; Walking; Wireless Technology; adipokines; arm; base; blood pressure reduction; chemotherapy; cost; cost effective; dashboard; design; efficacy testing; experience; fitness; group intervention; handheld mobile device; improved; intervention effect; learning materials; neuromusculoskeletal; obesity risk; portability; prevent; prospective; psychosocial; public health relevance; sedentary; sedentary lifestyle; survivorship; therapy design; tool; treatment effect; web site

The five year survival rate among children diagnosed with acute lymphoblastic leukemia (ALL) has surpassed 90%. Unfortunately, cure is not without consequences. ALL survivors are at elevated risk for obesity, low bone mineral density, cardiomyopathy, peripheral neuropathy, and altered psychosocial functioning. Research is critically needed to provide survivors with tools to improve their long term health. Because children with leukemia are likely to adopt a sedentary lifestyle that persists long into survivorship, and because a sedentary lifestyle may perpetuate or exacerbate many of the complications experienced by ALL survivors, a portable and generalizable intervention that promotes physical activity and impacts fitness and biomarkers of cardiometabolic health in the first year after treatment may be of particular benefit. This proposal is designed to access the resources of the Children's Oncology Group (COG) and complements ongoing therapeutic protocols. It will draw upon the existing infrastructure and expertise of the COG to recruit a sample of children as they complete treatment for childhood ALL. The primary goals of this study are to evaluate the effects of a rewards-based physical activity intervention, delivered via an interactive website for children with ALL, during a six month period beginning any time during the first three months after the end of curative chemotherapy, on fitness, biomarkers of cardiometabolic health, inflammation, adipokine status, quality of life and school attendance. We also plan to evaluate if the effects of the intervention on markers of cardiometabolic health are mediated by changes in fitness. To achieve this goal we have designed a two-arm, prospective, randomized study with a rewards- based intervention group (N=192) and a control group (N=192). The control group will receive educational materials encouraging physical activity, including information about activity modifications for common neuromusculoskeletal deficits (e.g. neuropathy, weakness), and an activity monitor to record physical activity levels. The intervention group will receive the same educational materials, the activity monitor, and access to a rewards-based interactive website designed to motivate increased levels of physical activity. Intervention group participants will receive points based on physical activity levels. Points are redeemed for small gift cards ($5.00) during the course of the study. Based on our pilot study, the average child/adolescent will earn eight gift cards. Individual physical activity levels are uploaded to the website (with acknowledgement of the data upload for control group participants, and with an interactive video game-type dashboard for intervention group participants when the activity monitor is connected to a computer). Rewards and encouragement are provided by the website based on the intervention participants' measured physical activity levels. Children who are initially less active still earn points as the rewards system is based on individual baseline physical activity. Evaluation time points are planned at baseline, after intervention, and six months and one year after the intervention is completed.

被诊断为急性淋巴细胞白血病（ALL）的儿童的五年生存率已超过 90％。不幸的是，治愈并非没有后果。所有幸存者的肥胖风险较高，骨头低 矿物质密度，心肌病，周围神经病和社会心理功能改变。研究是 至关重要的是为幸存者提供改善长期健康的工具。因为白血病的孩子 可能会采用一种久坐的生活方式，这种生活方式长期存在于生存中，并且因为久坐的生活方式 可能会永久或加剧所有幸存者，便携式和 可推广的干预措施，促进体育活动并影响心脏代谢的健身和生物标志物 治疗后的第一年健康可能特别有益。该建议旨在访问 儿童肿瘤学组（COG）的资源并补充正在进行的治疗方案。它会画 在现有的基础设施和COG的专业知识上，以招募儿童样本完成 童年的治疗。这项研究的主要目标是评估基于奖励的影响 在六个月内，通过互动网站为所有人提供的互动网站进行体育锻炼干预措施 从治疗化疗结束后的前三个月开始，关于健身，生物标志物 心脏代谢健康，炎症，脂肪因子状况，生活质量和上学的出勤率。我们也是 计划评估干预措施对心脏代谢健康标记的影响是否通过变化介导 健身。为了实现这一目标，我们设计了一项两臂，前瞻性的随机研究，并获得了奖励 - 基于干预组（n = 192）和对照组（n = 192）。对照组将获得教育 鼓励体育锻炼的材料，包括有关共同活动修改的信息 神经肌肉骨骼缺陷（例如，神经病，弱点）和活动监测仪记录体育活动 水平。干预小组将获得相同的教育材料，活动监护仪，并访问 基于奖励的交互式网站旨在激发增加体育锻炼水平。干预组 参与者将根据体育锻炼水平获得积分。点数兑换为小礼品卡（$ 5.00） 在研究过程中。基于我们的试点研究，普通儿童/青少年将赚取八个礼物 牌。单个体育活动级别上传到网站（确认数据上传 适用于对照组的参与者，并配有互动视频游戏仪表板的干预组 参与者当活动监视器连接到计算机时）。提供奖励和鼓励 网站基于干预参与者的体育锻炼水平。最初是 由于奖励系统基于单个基线体育锻炼，因此较少的活跃仍然可以赚取积分。评估 在干预后的基线，干预后的六个月零一年的时间点计划时点 完全的。