ALCOHOL, HIV INFECTION AND HOST DEFENSE

酒精、HIV 感染和宿主防御

• 批准号: 7942507
• 负责人: STEVE NELSON
• 金额: $ 14.2万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7942507
• 关键词: ALCOHOL; HIV; INFECTION; HOST; DEFENSE

DESCRIPTION (provided by applicant): This is a renewal application for the ARC at the Louisiana State University Health Sciences Center (LSUHSC). The ARC is a multidisciplinary team of scientists from the LSUHSC, the Tulane National Primate Research Center (TNPRC), the Alton Ochsner Clinic Foundation, and Xavier University, a Historically Black College/University, whose broad focus is the effect of alcohol on human immunodeficiency virus (HIV) infection and disease progression. The ARC is built on a strong foundation of established and productive research scientists whose purpose is to advance the alcohol research field by promoting excellence in research, training, and education. The ARC fosters a coordinated, integrated and synergistic environment that facilitates maximal productivity and scientific excellence. The ARC is a regional and national research resource that strives to assume a leadership position in investigating the health consequences of alcohol abuse in the HIV infected population. We believe that the ARC is now well positioned to translate our research findings into health care practice and become a Comprehensive ARC. Our grant proposal for a Comprehensive Center consists of the following: Administrative Core Component, Animal Core Component, The Molecular/Cellular Biology Laboratory Core Component, four Research Components ("Alcohol, SIV Infection, and Host Defense", "Effects of Ethanol and Infection on Mitochondriai Death Signaling in Lymphocytes", "Alcohol and HIV Infection: Additive Neuropsychological Effects", "Alcohol, IL-17, and Klebsiella Pneumonia"), and a Pilot Project Component. The strengths of the proposal include our productivity, the highly interactive and multidisciplinary scope of our research in an area of great clinical significance, the novel and mechanistic nature of our investigations, and the organizational maturity of our ARC.

描述（由申请人提供）：这是路易斯安那州立大学健康科学中心（LSUHSC）的弧形申请。 ARC是来自LSUHSC的科学家组成的多学科团队，Tulane国家灵长类动物研究中心（TNPRC），Alton Ochsner Clinic Foundation和Xavier University，Xavier University是一所历史悠久的黑人学院/大学，其广泛的重点是酒精对人类免疫缺陷病毒（HIV）感染和疾病进展的影响。 ARC建立在建立和生产性研究科学家的坚实基础上，其目的是通过促进研究，培训和教育的卓越性来推进酒精研究领域。弧线促进了一个协调，综合和协同的环境，促进了最大的生产力和卓越的科学卓越。 ARC是一种区域和国家研究资源，旨在在调查艾滋病毒感染人群中酗酒的健康后果方面处于领导地位。我们认为，弧线现在已经有好处，可以将我们的研究发现转化为医疗保健实践，并成为全面的弧线。 Our grant proposal for a Comprehensive Center consists of the following: Administrative Core Component, Animal Core Component, The Molecular/Cellular Biology Laboratory Core Component, four Research Components ("Alcohol, SIV Infection, and Host Defense", "Effects of Ethanol and Infection on Mitochondriai Death Signaling in Lymphocytes", "Alcohol and HIV Infection: Additive Neuropsychological Effects", "Alcohol, IL-17, and Klebsiella肺炎”）和试点项目组成部分。该提案的优势包括我们研究的生产力，高度互动性和多学科范围，具有临床意义的领域，研究的新颖和机械性质以及我们的弧线的组织成熟度。