Administrative Core: Interventions to improve alcohol-related comorbidities along the gut-brain axis in persons with HIV infection

行政核心：改善艾滋病毒感染者沿肠-脑轴的酒精相关合并症的干预措施

• 批准号: 10682451
• 负责人: Robert L Cook
• 金额: $ 26.69万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682451
• 关键词: Acquired Immunodeficiency Syndrome; Advisory Committees; Affect; Age; Aging; Alcohols; Autonomic nervous system; Brain; Clinical; Clinical Research; Cognition; Cognitive; Collaborations; Communication; Communities; County; Data; Data Collection; Data Science Core; Development; Discipline; Doctor of Philosophy; Enrollment; Ensure; Epidemiology; Ethnic Origin; Faculty; Florida; Future; Geographic Distribution; Goals; Growth; HIV; HIV Infections; Health Personnel; Human Resources; Infrastructure; Institution; International; Intervention; Leadership; Link; Measures; Medicine; Memory; Monitor; National Institute on Alcohol Abuse and Alcoholism; Outcome; Paper; Pathway interactions; Patient Recruitments; Persons; Pilot Projects; Population Heterogeneity; Process; Protocols documentation; Quality Control; Race; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Safety; Sampling; Services; Strategic Planning; Structure; Students; Training; Training Activity; Training Programs; Universities; University resources; alcohol research; biobank; community engagement; community setting; comorbidity; cooking; experience; gut microbiome; gut-brain axis; improved; member; operation; organizational structure; professor; programs; recruit; reduced alcohol use; rural area; sexual minority; transmission process

The Administrative Core is an essential component of the P01 application. The Administrative Core will maintain a central leadership structure and support core resources for the two Research Component projects proposed in this P01. The Administrative Core will provide a research infrastructure that help to ensure harmonization of measures across the two projects, so that data can be combined for future analyses led by the P01 Data Science Core. The Administrative Core will help to connect the new P01 research activity with existing infrastructure that our team has developed over the past decade as part of Southern HIV Alcohol Research Consortium (SHARC). The Specific Aims of the Administrative Core are to: (1) Provide centralized leadership and strategic planning. (2) Provide administrative and clinical research support related to recruitment, data collection, safety monitoring, quality control, and biorepository storage. (3) Integrate our research with our ongoing training, development, and community engagement activities. The Administrative Core will support a P01 Leadership Committee, co-chaired by MPIs Drs Cook and Cohen, that will receive input from a Program Advisory Committee and a Community Advisory Board. The Administrative Core will provide shared support for general research administration, regulatory monitoring, and recruitment/data collection. The Administrative Core will also ensure staff training, clinical research monitoring, and biorepository storage. Core services will support an an ongoing research recruitment team based at the University of Miami (UM) that is integrated with several research support organizations at UM including the UM Center for AIDS Research (CFAR). The Administrative Core will connect our P01 research with our existing T32 training program and other training activities, with the community engagement activities of the SHARC, and with other national HIV-alcohol consortia and P01-related activities supported by NIAAA. Overall, the Administrative Core will help to ensure that the research conducted within this P01 is integrated and connected to other alcohol-HIV research teams nationally and internationally, that we develop a diverse research workforce via connection to our training programs and research collaborative network, and that we maintain partnerships with healthcare providers and the community.

管理核心是P01应用程序的基本组件。行政核心意志 维持中央领导结构，并为两个研究组成部分项目提供核心资源支持 在本P01中建议。行政核心将提供一个研究基础设施，帮助确保 统一两个项目的措施，以便将数据结合起来，供今后由 P01数据科学核心。行政核心将帮助将新的P01研究活动与 我们的团队在过去十年中开发的现有基础设施，作为南方艾滋病毒酒精的一部分 研究联盟(SHARC)。行政核心的具体目标是：(1)提供集中的 领导力和战略规划。(2)提供行政和临床研究方面的支持 招募、数据收集、安全监测、质量控制和生物库储存。(3)整合我们的 通过我们正在进行的培训、开发和社区参与活动进行研究。行政部门 CORE将支持由MPIS DRS Cook和Cohen共同主持的P01领导委员会，该委员会将获得 来自方案咨询委员会和社区咨询委员会的意见。行政核心意志 为一般研究管理、监管监控和招聘/数据提供共享支持 收集。行政核心还将确保工作人员培训、临床研究监测和 生物储存库存储。核心服务将支持一个持续的研究招聘团队，总部设在 迈阿密大学(UM)，与包括UM在内的几个UM研究支持组织整合 艾滋病研究中心(CFAR)。行政核心将把我们的P01研究与我们现有的 T32培训计划和其他培训活动，配合SHARC的社区参与活动， 并与其他国家艾滋病毒-酒精联盟和NIAAA支持的与P01相关的活动。总体而言， 行政核心将有助于确保在本P01中进行的研究是综合的和相互联系的 给国内和国际上的其他酒精-艾滋病毒研究团队，我们开发了一项多样化的研究 员工通过连接到我们的培训计划和研究协作网络，并且我们保持 与医疗保健提供者和社区建立伙伴关系。