SBIR TOPIC 259: QUANTITATIVE TISSUE IMAGING FOR CLINICAL DIAGNOSIS AND PROGNOSIS
SBIR TOPIC 259: QUANTITATIVE TISSUE IMAGING FOR CLINICAL DIAGNOSIS AND PROGNOSIS
批准号:
7962742
负责人:
WALDEMAR Wilfried LERNHARDT
金额:
$13.93万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-09-30 至 2010-03-30
中文摘要
尽管我们对癌症的理解有了进步,新的治疗方法也有了发展,但癌症仍然存在
英文摘要
Despite advances in our understanding of cancer and the development of new therapeutics, cancer remains
the number two killer in the US with mortality rates of many cancers remaining relatively unchanged for
decades. Prostate cancer is the most common cancer and second leading cause of cancer-related death
among males of Western countries. There is a critical unmet need to identify reliable novel biomarkers to
assist in early detection of prostate cancer, and, most critically, to determine risk of prostate cancer
recurrence following initial lherapy such as prostatectomy. Currently Ihe major treatment modality for newly
diagnosed prostate cancer remains radical prostatectomy. Radical prostatectomy provides an excellent
outcome for organ-confined disease. However, 15%-20% or more of all surgical patients ultimately
experience recurrence indicating the presence of residual disease, local invasion andlor metastatic deposits
at the time of surgery .We are developing a new test using novel methods that identify cell-specific
biomarkers that can be applied at the time of diagnosis to determine whether the tumor has the potentia! to
recur after surgery. The development of a clinical test capable of distinguishing indolent and aggressive
forms of the disease at the time of diagnosis wi ll provide crucial guidance. First, this information will provide
guidance as to who needs treatment thereby providing the option of avoiding surgery and the associated
morbidity for those patients with a high risk of recurrence. Second, this information will also provide guidance
as to who may profit from postsurgery or immediate adjuvant therapy.
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