Basic validation studies of endocannabinoids levels in hair for use in psychological and biomedical research

用于心理和生物医学研究的头发内源性大麻素水平的基本验证研究

• 批准号: 422794550
• 负责人: Dr. Wei Gao, Ph.D.
• 金额: --
• 依托单位: Professur für Biopsychologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/422794550?language=en
• 关键词: Basic; validation; studies; endocannabinoids; levels

Endocannabinoids (ECs) appear to play important roles in stress-related processes and in the development of anxiety and affective disorders, respectively. While blood levels reflect EC bioavailability for a rather limited time period from hours to a few days, the concentration of ECs in hair may provide an integral biomarker covering several months. Despite promising pilot study results suggesting the usefulness of hair ECs assessments, fundamental information is still needed regarding the validity and reliability of this approach to characterize the body´s EC system. Therefore, a series of four studies are planned that will address a range of variables of potential influence on the levels of ECs quantified in hair extracts. The present proposal thus aims to evaluate the use of hair ECs measurements in biomedical and psychological research with a special focus on the validity and reliability of the method.

内源性大麻素（ECs）似乎分别在压力相关过程和焦虑和情感障碍的发展中发挥重要作用。虽然血液中EC的浓度反映的是几个小时到几天的有限时间内EC的生物利用度，但头发中EC的浓度可能提供覆盖几个月的完整生物标志物。尽管有希望的初步研究结果表明头发EC评估的有效性，但关于这种方法表征人体EC系统的有效性和可靠性的基本信息仍然需要。因此，计划进行一系列四项研究，以解决对头发提取物中量化的ECs水平的潜在影响的一系列变量。因此，本提案旨在评估头发ECs测量在生物医学和心理学研究中的应用，特别关注该方法的有效性和可靠性。