BIOMEDICAL (BASIC)

生物医学（基础）

• 批准号: 7938488
• 负责人: Nancy R Cook
• 金额: $ 120.46万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-15 至 2011-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7938488
• 关键词: BIOMEDICAL; BASIC

Risk prediction models for cardiovascular disease have been developed primarily among white men and women, with little validation in multi-ethnic populations. The overall aim of the current proposal is to validate existing Framingham and Reynolds risk scores, and to explore new predictive models for cardiovascular disease (CVD), including MI, stroke, and CVD mortality in the Women's Health Initiative Observational Study. An effcient case-cohort sample of 4000 women will be used, including 2000 cases spread across ethnic groups, and a subcohort of at least 2000 women frequency matched to the cases by race/ethnicity and 1 O-year age groups. This proposal will validate current models both overall and separately in subgroups defined by race/ethnicity. We wil fi new models in subpopulations separately, particularly Caucasian and African-American women, and wil fit models for CHD and stroke separately in the total cohort. Current risk prediction models contain blood-based biomarkers, but do not include measures of adiposity or physical activity. We will explore models without blood-based biomarkers, and compare these to models using such measures. We will also explore the contribution of new proposed biomarkers for risk prediction beyond those already included in the Framingham and Reynolds models, including lipoprotein-associated phospholipase A2 (Lp-PLA), tissue plasminogen activator (tPA antigen), and amino-terminal pro-B-type natriuretic peptide (proBNP), In addition, we will refine methods for the comparison of risk prediction models, including examining the statistical properties of clinical reclassification and its summary measures.

心血管疾病的风险预测模型主要是在白人男性和女性中开发的，在多种族人群中几乎没有得到验证。该计划的总体目标是 目前的建议是验证现有的Framingham和Reynolds风险评分，并探索新的心血管疾病(CVD)预测模型，包括MI、中风和CVD死亡率。 妇女健康倡议观察性研究。将使用4000名妇女的有效病例队列样本，其中包括2000例分布在各族裔群体中的病例，以及亚队列中的 至少有2000名妇女按种族/民族和1岁年龄组与病例匹配。该提案将在以下定义的子组中整体和单独验证当前模型 种族/民族。我们将分别在亚群中，特别是高加索和非裔美国女性中建立新的模型，并在总队列中分别适合CHD和中风的模型。 目前的风险预测模型包含基于血液的生物标记物，但不包括肥胖或体力活动的衡量标准。我们将探索没有血液生物标记物的模型，以及 将这些与使用此类衡量标准的模型进行比较。我们还将探索新的拟议生物标记物对风险预测的贡献，而不是那些已包括在Framingham和 雷诺模型，包括脂蛋白相关磷脂酶A2(Lp-PLA)、组织型纤溶酶原激活物(tPA抗原)和氨基末端前B型利钠肽(ProBNP)， 此外，我们还将改进风险预测模型的比较方法，包括检查临床重新分类的统计特性及其汇总措施。