OBSERVATIONAL COHORT STUDY OF SODIUM, WEIGHT AND CVD

钠、体重和 CVD 的观察性队列研究

• 批准号: 6653050
• 负责人: Nancy R Cook
• 金额: $ 37.28万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6653050
• 关键词: blood pressure; cardiovascular disorder; cardiovascular disorder epidemiology; clinical research; coronary disorder; diabetes mellitus; diet therapy; dietary sodium; disease /disorder prevention /control; human mortality; human subject; human therapy evaluation; hypertension; longitudinal human study; neoplasm /cancer; nutrition related tag; outcomes research; salt intake; saluresis; urinalysis; weight loss

Sodium reduction and weight loss lead to decreased blood pressure (BP). Among hypertensives, BP lowering leads to decreased risk of MI, stroke, and cardiovascular death. Nonetheless, concerns have been raised about increased numbers of cardiovascular events among individuals with low sodium intake or large weight changes. The proposed prospective observational follow-up of the Trials of Hypertension Prevention (TOHP) will include cardiovascular events among the 4, 507 surviving participants from the ten clinical centers involved in Phases I and II of TOHP. Phase I was a randomized trial of the effects of seen non- pharmacologic interventions, including sodium reduction and weight loss, on BP over 18 months of follow-up with 2,182 participants. Phase II examined the effects of sodium reduction and weight loss on BP over a longer 36-month period in a randomized 2X2 factorial design with 2,382 participants. During follow-up in Phases I and II of TOHP, several measures of both weight and sodium excretion were carefully obtained on all participants. The proposed prospective observational follow-up will specifically examine whether these values, with an emphasis on average level of sodium excretion and weight changes are predictive of later cardiovascular disease. The follow-up will be conducted centrally by mail from the Division of Preventive Medicine, which served as the Coordinating Center for Phases I and II, and which has been very successful in conducting such large-scale studies by mail. Information on cardiovascular events subsequent to the trial periods will be collected through June, 2003, representing an average follow-up of approximately fourteen years from the end of Phase I and eight years from the end of Phase II. This cohort provides a unique resource to address the impact in a normotensive population of salt restriction and weight change on subsequent cardiovascular events.

钠减少和体重减轻会导致血压（BP）下降。对于高血压患者，血压降低可降低心肌梗死、中风和心血管死亡的风险。尽管如此，人们仍然担心钠摄入量低或体重变化大的个体心血管事件的数量增加。高血压预防试验 (TOHP) 拟议的前瞻性观察性随访将包括来自参与 TOHP I 期和 II 期的 10 个临床中心的 4, 507 名幸存参与者的心血管事件。第一阶段是一项随机试验，对 2,182 名参与者进行了 18 个月的随访，研究了非药物干预措施（包括减少钠摄入和减肥）对血压的影响。 II 期研究采用随机 2X2 析因设计，有 2,382 名参与者参与，研究了在更长的 36 个月时间内减少钠摄入和减肥对血压的影响。在 TOHP 第一阶段和第二阶段的随访期间，仔细测量了所有参与者的体重和钠排泄量。拟议的前瞻性观察性随访将专门检查这些值（重点是钠排泄的平均水平和体重变化）是否可以预测以后的心血管疾病。后续工作将由预防医学部通过邮件集中进行，该部门作为第一阶段和第二阶段的协调中心，在通过邮件进行如此大规模的研究方面非常成功。试验期后心血管事件的信息将收集到 2003 年 6 月，这意味着从第一阶段结束后平均随访约十四年，从第二阶段结束后平均随访八年。该队列提供了独特的资源来解决血压正常人群的限盐和体重变化对随后心血管事件的影响。

项目成果

Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention.

• DOI: 10.1016/j.jacc.2016.07.745
• 发表时间: 2016-10-11
• 期刊: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
• 影响因子: 24
• 作者: Cook, Nancy R.;Appel, Lawrence J.;Whelton, Paul K.
• 通讯作者: Whelton, Paul K.