caBIG Affiliates

从caBIG开始，NCI指定的癌症中心以外的其他NCI研究项目就在那里启动，目标是让他们的IT基础设施与caBIG互操作。其中包括：综合癌症生物学计划(ICBP)、NCI纳米技术中心联盟(NANC)和肿瘤微环境网络。CBIIT/caBIG对这些计划的支持包括协调和协助开发与caBIG兼容的应用程序、基础设施和数据，以及开发和支持支持这些计划的门户网站。持续的支持对于维持这些努力是必要的。 正在重新规划扩大的支持，以满足三项快速增长的倡议的需要，即癌症基因组图谱(TCGA)、癌症易感性遗传标记(CGEMS)和NCI社区癌症中心计划(NCCCP)。在这些领域扩大努力将支持所有附属公司和更广泛的NCI企业。 癌症基因组图谱(TCGA) 癌症基因组图谱(TCGA)是一项全面和协调的努力，旨在通过应用基因组分析技术，包括大规模基因组测序，加速了解癌症的分子基础。TCGA的信息学部分涉及开发收集、存储和分发由该项目产生的临床和基因组数据的最佳方法。TCGA信息学利用caBIG(包括公共数据元素、元数据、中间件和应用程序)来实现分布式数据库之间的交互。CBIIT为TCGA数据协调中心提供资金。TCGA数据协调中心为基因组数据的分发和分析提供技术支持，并加强人类癌症生物基因组核心资源、基因组测序中心和癌症基因组表征中心之间存档和交换数据的能力。TCGA还将能够利用caBIG的资源来描述癌症基因组并开发癌症和癌前细胞的基因表达谱。 肿瘤易感性遗传标记(CGEMS) 癌症易感性遗传标记(CGEMS)项目正在进行一系列不断扩大的全基因组关联研究，以确定增加癌症风险的基因。每一次全基因组扫描分析了1000多个病例和1000个对照。正通过caBIG开发的数据门户向公众提供SNPs数据。一系列以人口为基础的大型研究正在分析和验证有希望的SNPs。CBIIT/caBIG负责通过公众可访问的储存库长期存储和提交数据。 NCI社区癌症中心项目(NCCCP) CBIIT的任务是通过应用caBIG技术支持NCCCP。这种支持包括评估10个参与组织的信息学能力，促进采用caBIG应用程序和基础设施以支持研究活动，以及探索利用caBIG基础设施创建癌症患者登记簿。

From the onset of the caBIG, additional NCI research projects outside the NCI-designated Cancer Center where launched with the goal having their IT infrastructure interoperate with caBIG. These include: the Integrated Cancer Biology Program (ICBP), The NCI Alliance of Nanotechnology Centers (NANC), and the Tumor Micro Environment Network. CBIIT/caBIG support for these programs includes coordination and assistance in developing caBIG compatible applications, infrastructure and data as well as the development and support of portals that support the initiatives. Ongoing support is necessary to maintain these efforts. Expanded support is being reprogrammed to meet the needs of three rapidly growing initiatives, The Cancer Genome Atlas (TCGA), the Cancer Genetic Markers of Susceptibility (CGEMS), and the NCI Community Cancer Center Program (NCCCP). Expanded effort in these areas will support all affiliates and the broader NCI Enterprise. The Cancer Genome Atlas (TCGA) The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing. The informatics component of TCGA involves developing the best ways to collect, store, and distribute the clinical and genomic data generated by the project. TCGA informatics leverages caBIG including common data elements, metadata, middleware, and applications to enable interactions among distributed databases. CBIIT provides funding for the TCGA Data Coordinating Center. The TCGA Data Coordinating Center provides technical support for the distribution and analysis of genomic data and underpin the ability to archive and exchange data among the Human Cancer Biospecimen Core Resource, the Genome Sequencing Centers, and the Cancer Genome Characterization Centers. TCGA also will be able to leverage resources from caBIG for cancer genome characterization and developing gene expression profiles of cancer and precancerous cells. Cancer Genetic Markers of Susceptibility (CGEMS) The Cancer Genetic Markers of Susceptibility (CGEMS) project is conducting an expanding collection of whole genome association studies to identify genes that increase the risk cancer. Each whole genome scan analyzes more than 1,000 cases and 1,000 controls. SNPs data are being made publicly available through a caBIG developed data portal. Promising SNPs are being analyzed and validated in a series of large, population-based studies. CBIIT/caBIG is responsible for the long-term storage and presentation of the data through a publicly-accessible repository. NCI Community Cancer Center Program (NCCCP) CBIIT has been tasked to support the NCCCP through the application caBIG technology. This support includes assessing the informatics capabilities of the 10 participating organizations, facilitating adoption of caBIG applications and infrastructure to support research activities, and exploring the creation of registries of cancer patients leveraging caBIG infrastructure.