caBIG Affiliates

caBIG 附属机构

• 批准号: 7970395
• 负责人: Kenneth Buetow
• 金额: $ 162.81万
• 依托单位: OFFICE OF THE DIRECTOR, NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7970395
• 关键词: Adoption; Archives; Area; Atlases; Cancer Biology; Cancer Center; Cancer Patient; Clinical; Collection; Common Data Element; Communities; Data; Data Coordinating Center; Development; Distributed Databases; Environment; Funding; Gene Expression; Genes; Genetic Markers; Genome; Genomics; Goals; Human; Informatics; Internet; Intervention; Malignant Neoplasms; Metadata; Mission; Molecular; Molecular Medicine; Molecular Profiling; Movement; NCI-Designated Cancer Center; Nanotechnology; Patients; Phase; Predisposition; Premalignant Cell; Registries; Research Activity; Research Infrastructure; Research Project Grants; Resources; Series; Technology; base; cancer Biomedical Informatics Grid; cancer genetics; cancer genome; cancer risk; data exchange; data portal; genome sequencing; genome wide association study; meetings; middleware; population based; programs; repository; tumor; virtual

From the onset of the caBIG, additional NCI research projects outside the NCI-designated Cancer Center where launched with the goal having their IT infrastructure interoperate with caBIG. These include: the Integrated Cancer Biology Program (ICBP), The NCI Alliance of Nanotechnology Centers (NANC), and the Tumor Micro Environment Network. CBIIT/caBIG support for these programs includes coordination and assistance in developing caBIG compatible applications, infrastructure and data as well as the development and support of portals that support the initiatives. Ongoing support is necessary to maintain these efforts. Expanded support is being reprogrammed to meet the needs of three rapidly growing initiatives, The Cancer Genome Atlas (TCGA), the Cancer Genetic Markers of Susceptibility (CGEMS), and the NCI Community Cancer Center Program (NCCCP). Expanded effort in these areas will support all affiliates and the broader NCI Enterprise. The Cancer Genome Atlas (TCGA) The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing. The informatics component of TCGA involves developing the best ways to collect, store, and distribute the clinical and genomic data generated by the project. TCGA informatics leverages caBIG including common data elements, metadata, middleware, and applications to enable interactions among distributed databases. CBIIT provides funding for the TCGA Data Coordinating Center. The TCGA Data Coordinating Center provides technical support for the distribution and analysis of genomic data and underpin the ability to archive and exchange data among the Human Cancer Biospecimen Core Resource, the Genome Sequencing Centers, and the Cancer Genome Characterization Centers. TCGA also will be able to leverage resources from caBIG for cancer genome characterization and developing gene expression profiles of cancer and precancerous cells. Cancer Genetic Markers of Susceptibility (CGEMS) The Cancer Genetic Markers of Susceptibility (CGEMS) project is conducting an expanding collection of whole genome association studies to identify genes that increase the risk cancer. Each whole genome scan analyzes more than 1,000 cases and 1,000 controls. SNPs data are being made publicly available through a caBIG developed data portal. Promising SNPs are being analyzed and validated in a series of large, population-based studies. CBIIT/caBIG is responsible for the long-term storage and presentation of the data through a publicly-accessible repository. NCI Community Cancer Center Program (NCCCP) CBIIT has been tasked to support the NCCCP through the application caBIG technology. This support includes assessing the informatics capabilities of the 10 participating organizations, facilitating adoption of caBIG applications and infrastructure to support research activities, and exploring the creation of registries of cancer patients leveraging caBIG infrastructure.

从caBIG开始，在NCI指定的癌症中心之外启动了其他NCI研究项目，目标是使其IT基础设施与caBIG互操作。其中包括：综合癌症生物学计划（ICBP），NCI纳米技术中心联盟（NANC）和肿瘤微环境网络。CBIIT/caBIG对这些计划的支持包括协调和协助开发与caBIG兼容的应用程序、基础设施和数据，以及开发和支持支持这些倡议的门户网站。要保持这些努力，就必须不断提供支助。 正在重新规划扩大的支持，以满足三个快速增长的倡议，癌症基因组图谱（TCGA），癌症遗传易感性标志物（CGEMS）和NCI社区癌症中心计划（NCCCP）的需求。在这些领域的扩大努力将支持所有附属公司和更广泛的NCI企业。 癌症基因组图谱（TCGA） 癌症基因组图谱（TCGA）是一个全面和协调的努力，通过应用基因组分析技术，包括大规模基因组测序，加速对癌症分子基础的理解。TCGA的信息学部分涉及开发收集，存储和分发项目生成的临床和基因组数据的最佳方法。TCGA信息学利用包括公共数据元素、元数据、中间件和应用程序在内的caBIG来实现分布式数据库之间的交互。CBIIT为TCGA数据协调中心提供资金。TCGA数据协调中心为基因组数据的分发和分析提供技术支持，并支持人类癌症生物标本核心资源，基因组测序中心和癌症基因组表征中心之间的存档和交换数据的能力。TCGA还将能够利用来自caBIG的资源进行癌症基因组表征，并开发癌症和癌前细胞的基因表达谱。 癌症易感性遗传标记（CGEMS） 癌症易感性遗传标记（CGEMS）项目正在进行一项扩大的全基因组关联研究，以确定增加癌症风险的基因。每次全基因组扫描分析超过1,000例病例和1,000例对照。SNPs数据通过caBIG开发的数据门户网站公开提供。有前途的SNP正在一系列大型的、基于人群的研究中进行分析和验证。CBIIT/caBIG负责通过一个可公开访问的存储库长期存储和展示数据。 NCI社区癌症中心计划（NCCCP） CBIIT的任务是通过应用caBIG技术支持NCCCP。这种支持包括评估10个参与组织的信息学能力，促进采用caBIG应用程序和基础设施来支持研究活动，并探索利用caBIG基础设施创建癌症患者登记处。