Establishment of Laboratory of Molecular Imaging and Nanomedicine

新的分子成像和纳米医学实验室的预期研究领域包括：1）分子成像探针开发-开发用于生物化学过程体内成像的分子成像探针，包括正电子发射断层扫描，光学成像（荧光和拉曼），磁共振成像，对比增强超声，光声和多模式成像。分子成像结合解剖和功能成像可以提高对疾病的理解，实现早期检测，并加强对治疗反应和药物发现和开发的监测。方法包括化学合成、蛋白质工程、生物缀合、放射性标记、化学分析、临床前研究和使用各种体外和体内技术的临床翻译。 2)纳米治疗诊断学--用于联合成像和治疗的水溶性、生物相容性纳米颗粒的合理设计。由聚合物、金属、陶瓷和脂质等材料合成的纳米颗粒（<100 nm）允许同时进行诊断成像、药物递送和治疗反应监测。方法包括合成、理化表征、表面修饰和生物缀合、药代动力学和啮齿动物中的药效学评价，以转化为临床应用。

Examples of intended areas of research of the new Laboratory of Molecular Imaging and Nanomedicine include: 1) Molecular Imaging Probe Development--Developing molecular imaging probes for in vivo imaging of biochemical processes, including positron emission tomography, optical imaging (fluorescence and Raman), magnetic resonance imaging, contrast enhanced ultrasound, photoacoustic and multimodal imaging. Molecular imaging in combination with anatomic and functional imaging can improve understanding of disease, enable early detection, and enhance monitoring of therapeutic responses and drug discovery and development. Methods include chemical synthesis, protein engineering, bioconjugation, radiolabeling, chemical analysis, preclinical studies, and clinical translation using various in vitro and in vivo techniques. 2) Nano Theranostics--Rational design of water-soluble, biocompatible nanoparticles for combined imaging and therapy. Nanoparticles (<100nm) synthesized from materials such as polymers, metals, ceramics and lipids permit simultaneous diagnostic imaging, drug delivery, and monitoring of therapeutic responses. Methods include synthesis, physiochemical characterization, surface modification and bioconjugation, pharmacokinetic, and pharmacodynamic evaluation in rodents for translation to clinical application.