HEART FAILURE MODELING IN RABBIT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 心力衰竭是普通人群死亡的主要原因。兔模型在深入了解导致心力衰竭的因素方面很重要。以前的实验表明：受反应扩散偏微分方程式支配的直线波，即使在完全均匀的组织中，也可以由于电不稳定性而变得不稳定和破裂。目前的工作是以兔心脏为模型系统，利用反应扩散偏微分方程组建立更好的模型来描述分子间的相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Heart failure is a leading cause of death in the general population. Rabbit models are important in providing insights into the factors contributing to heart failure. Previous experiments have indicated that: rectilinear waves, governed by reaction-diffusion partial differential equations, can become unstable and break up, even in perfectly homogeneous tissue, due to electrical instabilities. Current work aims to develop better models to describe the molecular interactions using reaction-diffusion PDE's using rabbit heart as the modeling system.