HEART FAILURE MODELING IN RABBIT

兔子心力衰竭模型

• 批准号: 7955267
• 负责人: Alan J Garfinkel
• 金额: $ 0.32万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955267
• 关键词: Binding; Biological Models; Biomedical Computing; Cause of Death; Computer Retrieval of Information on Scientific Projects Database; Diffusion; Equation; Funding; General Population; Grant; Heart; Heart failure; Institution; Modeling; Oryctolagus cuniculus; Reaction; Research; Research Personnel; Resources; Source; Tissues; United States National Institutes of Health; Work; insight; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Heart failure is a leading cause of death in the general population. Rabbit models are important in providing insights into the factors contributing to heart failure. Previous experiments have indicated that: rectilinear waves, governed by reaction-diffusion partial differential equations, can become unstable and break up, even in perfectly homogeneous tissue, due to electrical instabilities. Current work aims to develop better models to describe the molecular interactions using reaction-diffusion PDE's using rabbit heart as the modeling system.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 心力衰竭是一般人群的主要死亡原因。兔子模型在提供对心力衰竭因素的深入了解方面很重要。以前的实验已经表明：直线波，由反应扩散偏微分方程，可以变得不稳定和破碎，即使在完全均匀的组织，由于电气不稳定性。目前的工作旨在发展更好的模型来描述分子间的相互作用，使用反应扩散偏微分方程的使用兔心脏作为建模系统。