Interdepartmental Neuroscience Center

该应用程序的目标是更新核心设施，以支持马萨诸塞州的神经科学研究 综合医院(MGH)。MGH跨部门神经科学中心由大约50名教职员工组成， 在基础神经科学和应用神经科学方面有共同的兴趣。研究的重点是高影响力、全国性的 优先领域，如神经退行性疾病、发育性神经障碍、运动 疾病、创伤性/缺血性脑和脊髓损伤、脑肿瘤、疼痛、药物成瘾、基因治疗 和基础神经科学。自该中心成立以来，该中心的研究基地有了巨大的增长 成立于1988年。伴随着增长的是对共享的需求同样强劲和快速的增长 设备和设施。为了应对这种严重的短缺，该中心的调查人员提出了 机构和外部资金，以发展一些核心服务。2003年，在。NINDS P30的帮助下 奖励建立了一个新的核心设施计划。这项计划已经成为非常有价值的 支持神经科学研究，特别是新研究人员的研究，并促进新的合作。 本申请旨在恢复对这一核心设施方案的支持。我们进行了详细的 调查NINDS资助的实验室的需求，评估现有核心资源的利用情况。 根据调查和评价的结果，我们寻求支持，以更新和加强以下内容 核心：A)显微镜和图像分析，B)核酸定量和C)病毒载体的开发和 制作。还提出了支持该计划的行政核心。这些核心将满足需求 在NINDS资助的90个项目和非NINDS资助的项目中，根据计划指南。核心是 旨在支持正在进行的研究，特别是我们初级教员的研究，并刺激创新的发展 A)提供个人无法提供的服务、设备和专业知识 实验室和b)促进调查人员之间的协同互动。一个详细的计划，实现高效和 建议公平分配服务。这些核心已收到机构承诺的资金。 对于设备、工资和空间，不要重复现有的共享设施。

The goal of this application is to renew Core facilities to support neuroscience research at the Massachusetts General Hospital (MGH). The MGH Interdepartmental Neuroscience Center consists of about 50 faculty with shared interests in basic and applied neuroscience. The focus of the research is on high-impact, national priority areas such as neurodegenerative diseases, developmental neurological disorders, movement disorders, traumatic/ischemic brain and spinal cord injury, brain tumors, pain, drug addiction, gene therapy and basic neuroscience. The research base at the Center has grown enormously since the Center's inception in 1988. The growth is accompanied by an equally strong and rapid increase in demand for shared equipment and facilities. In response to this critical shortage, the Center's investigators have raised institutional and external funding to develop some core services. In 2003, with help from.the NINDS P30 award a new core facilities program was established. This program has become extremely valuable for sustaining neuroscience research, especially that of new investigators and for fostering new collaborations. The present application seeks to renew support for this core facilities program. We conducted detailed surveys of the needs of NINDS-funded laboratories and evaluated utilization of the existing core resources. Based on the results of the surveys and evaluations, we seek support to renew and enhance the following cores: A) Microscopy and image analysis, B) Nucleic acid quantitation and C) Viral vector development and production. An administrative core to support the program is also proposed. The cores will serve the needs of 90 NINDS funded projects and also non-NINDS funded projects as per program guidelines. The Cores are designed to support ongoing research, especially of our junior faculty, and to stimulate development of novel technology and research by a) offering service, equipment and expertise not available in individual laboratories and b) fostering synergistic interactions among the investigators. A detailed plan for efficient and equitable dispensation of services is proposed. The Cores have received institutional commitment of funds for equipment, salary and space and do not duplicate existing shared facilities.