Interdepartmental Neuroscience Center

本申请的目的是更新核心设施，以支持马萨诸塞州的神经科学研究 综合医院。MGH跨部门神经科学中心由大约50名教师组成， 对基础和应用神经科学有共同的兴趣。研究的重点是高影响力，国家 优先领域，如神经退行性疾病、发育性神经障碍、运动 疾病、创伤性/缺血性脑和脊髓损伤、脑肿瘤、疼痛、药物成瘾、基因治疗 和基础神经科学。自中心成立以来，该中心的研究基地已大大发展。 成立于1988年。伴随着这种增长的是对共享的需求同样强劲和快速的增长。 设备和设施。为了应对这一严重短缺，该中心的调查人员提出了 机构和外部资金，以发展一些核心服务。2003年，在NINDS P30的帮助下， 设立了一个新的核心设施项目。该计划已成为非常有价值的， 支持神经科学研究，特别是新的研究人员和促进新的合作。 本申请寻求更新对该核心设施计划的支持。我们进行了详细的 调查NINDS资助的实验室的需求，并评估现有核心资源的利用情况。 根据调查和评价的结果，我们寻求支持，以更新和加强以下方面： 核心：A）显微镜和图像分析，B）核酸定量和C）病毒载体开发和 生产还提出了一个支持该方案的行政核心。核心将满足需求 90个NINDS资助的项目和非NINDS资助的项目。述核心 旨在支持正在进行的研究，特别是我们的初级教师，并刺激小说的发展 技术和研究a）提供个人无法提供的服务、设备和专门知识 实验室和B）促进研究者之间的协同互动。一个详细的计划， 建议公平分配服务。核心委员会已收到机构承诺的资金 不重复现有的共用设施。

The goal of this application is to renew Core facilities to support neuroscience research at the Massachusetts General Hospital (MGH). The MGH Interdepartmental Neuroscience Center consists of about 50 faculty with shared interests in basic and applied neuroscience. The focus of the research is on high-impact, national priority areas such as neurodegenerative diseases, developmental neurological disorders, movement disorders, traumatic/ischemic brain and spinal cord injury, brain tumors, pain, drug addiction, gene therapy and basic neuroscience. The research base at the Center has grown enormously since the Center's inception in 1988. The growth is accompanied by an equally strong and rapid increase in demand for shared equipment and facilities. In response to this critical shortage, the Center's investigators have raised institutional and external funding to develop some core services. In 2003, with help from.the NINDS P30 award a new core facilities program was established. This program has become extremely valuable for sustaining neuroscience research, especially that of new investigators and for fostering new collaborations. The present application seeks to renew support for this core facilities program. We conducted detailed surveys of the needs of NINDS-funded laboratories and evaluated utilization of the existing core resources. Based on the results of the surveys and evaluations, we seek support to renew and enhance the following cores: A) Microscopy and image analysis, B) Nucleic acid quantitation and C) Viral vector development and production. An administrative core to support the program is also proposed. The cores will serve the needs of 90 NINDS funded projects and also non-NINDS funded projects as per program guidelines. The Cores are designed to support ongoing research, especially of our junior faculty, and to stimulate development of novel technology and research by a) offering service, equipment and expertise not available in individual laboratories and b) fostering synergistic interactions among the investigators. A detailed plan for efficient and equitable dispensation of services is proposed. The Cores have received institutional commitment of funds for equipment, salary and space and do not duplicate existing shared facilities.