Interdepartmental Neuroscience Center

跨部门神经科学中心

• 批准号: 7790222
• 负责人: PRADEEP G BHIDE
• 金额: $ 13.13万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-21 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7790222
• 关键词: Adherence; Area; Arts; Award; Biology; Brain Neoplasms; Cancer Grant Supplements (P30); Collaborations; Communities; Computer software; Core Facility; DNA; Development; Diagnosis; Disease; Drug Addiction; Ensure; Equipment; Evaluation; Faculty; Feedback; Fostering; Funding; Gene Expression Regulation; General Hospitals; Goals; Growth; Guidelines; Image Analysis; Individual; Laboratories; Massachusetts; Measurement; Microscopy; Movement Disorders; National Institute of Neurological Disorders and Stroke; Neurodegenerative Disorders; Neurosciences; Neurosciences Research; Pain; Performance; Production; Productivity; Qualifying; RNA; Reporter Genes; Research; Research Activity; Research Personnel; Research Support; Resources; Retroviral Vector; Services; Source; Surveys; Time; Transgenes; United States National Institutes of Health; Wages; base; design; gene therapy; imaging modality; interest; nervous system disorder; new technology; novel; nucleic acid quantitation; programs; promoter; response; satisfaction; spinal cord and brain injury; tool; tool development; vector; viral vector development

The goal of this application is to renew Core facilities to support neuroscience research at the Massachusetts General Hospital (MGH). The MGH Interdepartmental Neuroscience Center consists of about 50 faculty with shared interests in basic and applied neuroscience. The focus of the research is on high-impact, national priority areas such as neurodegenerative diseases, developmental neurological disorders, movement disorders, traumatic/ischemic brain and spinal cord injury, brain tumors, pain, drug addiction, gene therapy and basic neuroscience. The research base at the Center has grown enormously since the Center's inception in 1988. The growth is accompanied by an equally strong and rapid increase in demand for shared equipment and facilities. In response to this critical shortage, the Center's investigators have raised institutional and external funding to develop some core services. In 2003, with help from.the NINDS P30 award a new core facilities program was established. This program has become extremely valuable for sustaining neuroscience research, especially that of new investigators and for fostering new collaborations. The present application seeks to renew support for this core facilities program. We conducted detailed surveys of the needs of NINDS-funded laboratories and evaluated utilization of the existing core resources. Based on the results of the surveys and evaluations, we seek support to renew and enhance the following cores: A) Microscopy and image analysis, B) Nucleic acid quantitation and C) Viral vector development and production. An administrative core to support the program is also proposed. The cores will serve the needs of 90 NINDS funded projects and also non-NINDS funded projects as per program guidelines. The Cores are designed to support ongoing research, especially of our junior faculty, and to stimulate development of novel technology and research by a) offering service, equipment and expertise not available in individual laboratories and b) fostering synergistic interactions among the investigators. A detailed plan for efficient and equitable dispensation of services is proposed. The Cores have received institutional commitment of funds for equipment, salary and space and do not duplicate existing shared facilities.

该应用程序的目标是更新核心设施以支持马萨诸塞州的神经科学研究 综合医院（MGH）。 MGH 跨部门神经科学中心由约 50 名教职人员组成 对基础和应用神经科学有共同的兴趣。研究的重点是具有高影响力的国家级 优先领域，如神经退行性疾病、发育性神经障碍、运动 疾病、创伤性/缺血性脑和脊髓损伤、脑肿瘤、疼痛、药物成瘾、基因治疗 和基础神经科学。自该中心成立以来，该中心的研究基础得到了巨大的发展。 1988年成立。伴随着这一增长的是对共享的需求同样强劲和快速的增长 设备和设施。为了应对这一严重短缺，该中心的调查人员提出了 机构和外部资金用于开发一些核心服务。 2003年，在NINDS P30的帮助下 奖励建立了一个新的核心设施计划。该计划对于 维持神经科学研究，特别是新研究人员的研究并促进新的合作。 本申请旨在继续支持这一核心设施计划。我们进行了详细的 调查 NINDS 资助的实验室的需求并评估现有核心资源的利用情况。 根据调查和评估的结果，我们寻求支持以更新和增强以下内容 核心：A) 显微镜和图像分析，B) 核酸定量，以及 C) 病毒载体开发和 生产。还提出了支持该计划的行政核心。核心将满足需求 根据计划指南，共有 90 个 NINDS 资助的项目以及非 NINDS 资助的项目。核心是 旨在支持正在进行的研究，特别是我们的初级教师的研究，并刺激新颖的发展 a) 提供个人无法获得的服务、设备和专业知识 实验室和 b) 促进研究人员之间的协同互动。高效、高效的详细计划 建议公平分配服务。核心已获得机构资金承诺 设备、工资和空间，并且不要重复现有的共享设施。