Tissue Procurement Facility

组织采购设施

• 批准号: 7944904
• 负责人: AMY PATRICE SKUBITZ
• 金额: $ 6.92万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-08 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944904
• 关键词: Area; Ascites; Biopsy; Blood; Breast; Cancer Center; Cancer Center Support Grant; Clinical; Clinical Data; Clinical Research; Code; Consent; Consent Forms; Consultations; Cryopreservation; Custom; Cytology; Databases; Diagnosis; Ensure; Fine needle aspiration biopsy; Formalin; Freezing; Fresh Tissue; Frozen Sections; Funding; Goals; Human; Human Resources; Individual; Laboratories; Lasers; Liquid substance; Maintenance; Malignant - descriptor; Malignant Neoplasms; Medical; Microdissection; Microtome - medical device; Minnesota; Mission; Nitrogen; Normal tissue morphology; Operating Room Nursing; Operating Rooms; Operative Surgical Procedures; Organ; Pancreas; Paraffin; Pathologist; Pathology Report; Patients; Peer Review; Pleural; Procedures; Process; Productivity; Protocols documentation; Quality Control; Research; Research Ethics Committees; Research Personnel; Resources; Saliva; Sampling; Schedule; Secure; Services; Slide; Solid; Solid Neoplasm; Specific qualifier value; Specimen; Staining method; Stains; Standardization; Sterility; Surgical Pathology; System; Technology; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Universities; University of Minnesota Cancer Center; Urine; Work; Workplace; abstracting; clinical research site; design; meetings; member; repository; sensor; tumor; wasting

9.7.1 ABSTRACT: TISSUE PROCUREMENT FACILITY Director: Amy Skubitz .. ¿ The mission of the Tissue Procurement Facility (hereafter abbreviated TPF) is to procure samples from¿ . patients in support of basic, translational; and clinical cancer researchers at the University of Minnesota ' Cancer Center who are currently funded by national peer-reviewed agencies. Our goal is to develop a repository of patient-derived specimens including well preserved samples of malignant and benigri tumors, rare tumors, organ matched normal tissue, and when possible, unrelated normal tissues. The TPF is a centralized resource thatcontrols for: standardization of tissue sample processing, storage, quality control, distribution, patient consent, and record maintenance. The TPF has office and laboratory space which is . , contiguous with Surgical Pathology's frozen satellite area and operating rooms of the University of Minnesota MedicalCenter, Fairview. The TPF has two liquid nitrogen freezers and one -80C freezer,with aooxygen ¿. sensor and an alarm system. Acryostatand microtome areavailable for hourly .usage by researchers. The TPF works seamlessly with the activities of 'the Surgical Pathology Division, such that waste tissues are ¿ processed by: (a) freezing in liquid nitrogen; (b) embedding in a cryopreservative, then freezing at -80¿C; (c) . fixing in formalin, then embedding in paraffin; and (d) maintaining as fresh tissue foYimmediate use: We ensure that all patients sign our consent form prior to our procurement of their waste tissue, which may . include solid tumors, normal solid tissue, blood, urine, saliva, and ascites fluid. In addition, we "custom design" the way tissue specimens are procured in order to fulfill the Individual requests of each of the Cancer Center members. In order to meet the increasing tissue needs of Cancer Center members, we plan to expand our services to procure cytology specimens, (including pancreatic fine needle aspiration specimens, pleural fluid, and ascites fluid). Wewill also provide researchers with tissue microarrays and perform laser, . capture microdissection and immunohistochemical staining of samples

9.7.1摘要：组织采购因素 导演：Amy Skubitz.. 组织采购机构（以下简称TPF）的使命是从组织中采购样本。 支持明尼苏达大学基础、转化和临床癌症研究人员的患者 目前由国家同行评审机构资助的癌症中心。我们的目标是发展一个 患者来源的标本的储存库，包括保存良好的恶性和良性肿瘤样品， 罕见的肿瘤，器官匹配的正常组织，如果可能，无关的正常组织。TPF是一个 集中资源，控制：组织样本处理，储存，质量控制， 分发、患者同意和记录维护。TPF拥有办公室和实验室空间。 毗邻明尼苏达大学外科病理学冷冻卫星区和手术室 美景镇医疗中心TPF有两个液氮冷冻机和一个-80 ℃冷冻机， ¿.传感器和报警系统。Acryostat和切片机可供研究人员每小时使用。的 TPF与“外科病理学部”的活动无缝合作， 通过以下方法处理：（a）在液氮中冷冻;（B）包埋在冷冻保存剂中，然后在-80 ° C下冷冻;（c）。 福尔马林固定，石蜡包埋;（d）保存为新鲜组织，用途：我们 确保所有患者在我们采购他们的废组织之前签署我们的同意书，这可能 .包括实体瘤、正常实体组织、血液、尿液、唾液和腹水。此外，我们“自定义 设计”组织标本的采购方式，以满足每个癌症患者的个人要求， 中心成员。为了满足癌症中心成员日益增长的组织需求，我们计划 扩大我们的服务，以采购细胞学标本，（包括胰腺细针穿刺标本， 胸膜液和腹水）。我们还将为研究人员提供组织微阵列和进行激光，。 捕获样品的显微切割和免疫组织化学染色