CORE C: Statistics & Methodology Services

核心C人员提供出色的技术和方法咨询，并产生新的知识 通过帮助生物医学和行为研究人员开发解决数据分析问题的最佳方法 这限制了他们的工作。“产生式”解决方案不同于“最先进的”解决方案。“最先进的技术”指的是 专家研究人员已知的高级解决方案。“生成性”解决方案以新颖的方式超越了最先进的水平 解决办法。可能会导致在方法期刊上发表文章。(请参阅Core 0发布的出版物 前和后顾问詹妮弗·布莱克福德、李春、乔恩·塔普和莉莉·王在《章节》发表名单中 C3.5.3.5) 随着现代研究的复杂性降低，专门的统计援助已成为强制性的 大多数研究人员。当普通评审员第一个注意到设计或分析中的问题时，往往为时已晚。 解决它们。核心0人员帮助调查人员以最新的设计和分析计划开始他们的研究。 Core C在高度协作的环境中运行，便于使用最复杂的 应用统计和数据库管理方法，并产生新的分析战略和 方法论。核心人员在观察方法、生物和行为统计方面具有专业知识， 统计遗传学、实验设计和多元统计。核心的专业知识因Close而得到加强 与范德比尔特大学医学院生物统计学系合作。 自2003年对核心进行P30审查以来，核心0中最重大的变化之一是增加了 与生物统计部的合作。范德利迪尔特医学院创建了 生物统计学，2003年9月。在这样做的过程中，范德比尔特做出了建设世界一流水平的重大资金承诺 该系将在2010年包括一个博士级别的博士课程。主席由小弗兰克·E·哈威尔博士担任，他还 作为核心C部门的主管，这个部门拥有特殊的机构支持。年生物统计学家的愿景 该部门的特点是，他们成为走在生物医学研究前沿的统计科学家，他们 促进医学和生物统计学方面的知识体系。 从历史上看，VKC注意到了与人类行为研究相关的统计学分析的优势；然而，在 2003年，NICHD P30审查小组注意到生物医学统计专业知识方面的不足。为了满足这一需求， VKC和生物统计公司在2004年启动了合作伙伴关系，包括两名具有生物学专业知识的博士生物统计学家 和遗传数据分析在核心C(王和李)。2006年任命Frank han-ell为Core C董事 进一步巩固了这种伙伴关系。VKC和生物统计部之间的这种关系一直是 互惠互利。该部门已将其最初的作用从医学研究扩展到包括大型 多学科和翻译研究合作的数量，VKC加强了其 行政领导及其向调查人员提供高质量生物统计学支持的能力。 VKC招聘者和实习生参加Core C提供的研讨会和实施的日常无预约诊所 由生物统计部与包括VKC在内的合作伙伴共同完成。这种高效、互动性的证据 关系出现在共同撰写的出版物、Word&lt；商店和培训课程中，这些课程一直在丰富 VKC调查员社区。作为2003年以来改革成效的一个例证， VKC的调查人员在2003至2006年间每个季度的服务几乎翻了一番。此外，还有一种平衡的 核心C服务在VKC行为学和生物医学研究人员之间的分布。

Core C personnel provide outstanding stafistical and methodological consulting, and they generate new knowledge by helping biomedical and behavioral researchers develop the best approaches to solving data analytic problems that limit their wori<. "Generative" solutions are distinguished from "state of the art." "State of the art" refers to most advanced solutions known to expert researchers. "Generative" solutions push beyond the state of the art with novel solutions. Tmly generative wori^ may lead to published articles in methods journals. (See publications by Core 0 fomner and cun-ent consultants Jennifer Blackiford, Chun Li, Jon Tapp, and Lily Wang in the publication list in Section C3.5.3.5) As the complexity of modem research has inaeased, specialized statistical assistance has become mandatory for most researchers. When joumal reviewers are the first to notice problems in design or analysis, it is often too late to solve them. Core 0 personnel help investigators begin their research with up-to-date designs and analytic plans. Core C operates within a highly collaborative environment that facilitates the use of the most sophisticated application of stafistical and database management methodologies and that generates new analytical strategies and methodologies. Core personnel have expertise in observational methodologies, bio- and behavioral statistics, statisfical genefics, experimental design, and multivariate statistics. The Core's expertise is reinforced by close collaboration with the Department of Biostatistics at the Vanderbilt University School of Medicine. One of the most significant changes instituted in Core 0 since the 2003 P30 review of the Core is increased collaboration with the Department of Biostatisfics. VanderiDilt's School of Medicine created the Department of Biostatistics in September 2003. In doing so, Vanderbilt made a major funding commitment to build a worid-class department that will include a doctoral-level PhD program in 2010. Chaired by Frank E. Harwell, Jr., PhD, who also serves as Director of Core C, this department has excepfional institutional support. The vision for biostatisticians in the Department is that they become statistical scientists who are on the forefront of biomedical research and who contribute to the body of knowledge in medicine and in biostatistics. Historically, the VKC had noted strengths in stafistical analysis related to human behavioral studies; however, in 2003, the NICHD P30 review panel noted shortcomings in biomedical statistical expertise. To address this need, the VKC and Biostatisfics initiated a partnership in 2004 by including two PhD biostatisticians with expertise in biological and genetic data analysis in Core C (Wang and Li). The appointment of Frank Han-ell as Director of Core C In 2006 further cemented the partnership. This relationship between the VKC and the Department of Biostatistics has been mutually beneficial. The Department has extended its original role beyond medical research to include a large number of multidisciplinary and translational research collaborations, and the VKC has strengthened its administrative leadership and its ability to provide high-quality biostatistical support to investigators. VKC invesfigators and trainees participate in workshops offered by Core C and in a daily walk-in clinic implemented by the Department of Biostatistics, with partners that include the VKC. Evidence of this productive, interactive relationship appears in co-authored publications, wori<shops, and training sessions that have been enriching the community of VKC investigators. As an illustration of the effectiveness of the changes since 2003, the number of VKC investigators served each quarter almost doubled between 2003 and 2006. Moreover, there is a balanced distribution of ufilization of Core C services between VKC behavioral and biomedical researchers.