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Mechanisms of mast cell influence on EAE disease course

Mechanisms of mast cell influence on EAE disease course
肥大细胞对EAE病程影响的机制
批准号：
7751828
负责人：
Melissa A Brown
金额：
$25.7万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
项目状态：
已结题
起止时间：
2006-01-01 至 2011-08-31
来源：
https://reporter.nih.gov/project-details/7751828
关键词：
AffectAnimalsAntigensAutoimmune ProcessB-LymphocytesBlood - brain barrier anatomyBlood VesselsBone MarrowBreedingCD4 Positive T LymphocytesCD8B1 geneCell Surface ProteinsCell physiologyCellsDendritic CellsDiseaseDisease susceptibilityEncephalomyelitisEpitopesEventExhibitsExperimental Autoimmune EncephalomyelitisFaceFlow CytometryFrequenciesGenerationsGenesHistamineHistamine ReleaseHomingImmunizationInflammatoryInterleukin-10Interleukin-4LeadLittle&aposs DiseaseLymphocyteLymphoidMediator of activation proteinMelissaMethodsModelingMouse StrainsMultiple SclerosisMusMyelinMyelin SheathNerveOrganOutcomePeptide HydrolasesPhasePhenotypePlayPopulationPredispositionPrintingProceduresProductionRegulationRelapseRelative (related person)Research PersonnelResearch Project GrantsRespiratory SystemRespiratory tract structureRodent ModelRoleSJL MouseSecondary toSeveritiesSiteSkinSpleenStagingStudy modelsSyndromeT cell differentiationT cell regulationT cell responseT-Cell ActivationT-LymphocyteTNFSF5 geneTestingTissuesTransgenic Organismsallergic responseautoreactive T cellbasechemokinecytokineimmune functionlymph nodesmacrophagemast cellmigrationoligodendrocyte-myelin glycoproteinprogramsreceptorreconstitutionresponserestorationtrafficking

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期刊论文(2)
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会议论文
Meningeal Mast Cells Affect Early T Cell Central Nervous System Infiltration and Blood-Brain Barrier Integrity through TNF: A Role for Neutrophil Recruitment?
DOI： 10.4049/jimmunol.1000126
发表时间： 2010-06-15
期刊： JOURNAL OF IMMUNOLOGY
影响因子： 4.4
作者： [Sayed, Blayne A., Christy, Alison L., Brown, Melissa A.]
通讯作者： Brown, Melissa A.
New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action?
DOI： 10.1016/j.bbadis.2011.02.009
发表时间： 2012-01
期刊： BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
影响因子： 6.2
作者： [Walker, Margaret E., Hatfield, Julianne K., Brown, Melissa A.]
通讯作者： Brown, Melissa A.
Distinct mast cell responses in male and female SJL mice underlie sex dimorphic EAE susceptibility
Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL Mice
Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL Mice
Ikaros in mast vs. basophil lineage choice
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