Mechanisms of mast cell influence on EAE disease course

肥大细胞对EAE病程影响的机制

• 批准号: 7751828
• 负责人: Melissa A Brown
• 金额: $ 25.7万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7751828
• 关键词: Affect; Animals; Antigens; Autoimmune Process; B-Lymphocytes; Blood - brain barrier anatomy; Blood Vessels; Bone Marrow; Breeding; CD4 Positive T Lymphocytes; CD8B1 gene; Cell Surface Proteins; Cell physiology; Cells; Dendritic Cells; Disease; Disease susceptibility; Encephalomyelitis; Epitopes; Event; Exhibits; Experimental Autoimmune Encephalomyelitis; Face; Flow Cytometry; Frequencies; Generations; Genes; Histamine; Histamine Release; Homing; Immunization; Inflammatory; Interleukin-10; Interleukin-4; Lead; Little' s Disease; Lymphocyte; Lymphoid; Mediator of activation protein; Melissa; Methods; Modeling; Mouse Strains; Multiple Sclerosis; Mus; Myelin; Myelin Sheath; Nerve; Organ; Outcome; Peptide Hydrolases; Phase; Phenotype; Play; Population; Predisposition; Printing; Procedures; Production; Regulation; Relapse; Relative (related person); Research Personnel; Research Project Grants; Respiratory System; Respiratory tract structure; Rodent Model; Role; SJL Mouse; Secondary to; Severities; Site; Skin; Spleen; Staging; Study models; Syndrome; T cell differentiation; T cell regulation; T cell response; T-Cell Activation; T-Lymphocyte; TNFSF5 gene; Testing; Tissues; Transgenic Organisms; allergic response; autoreactive T cell; base; chemokine; cytokine; immune function; lymph nodes; macrophage; mast cell; migration; oligodendrocyte-myelin glycoprotein; programs; receptor; reconstitution; response; restoration; trafficking

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项目成果

Meningeal Mast Cells Affect Early T Cell Central Nervous System Infiltration and Blood-Brain Barrier Integrity through TNF: A Role for Neutrophil Recruitment?

• DOI: 10.4049/jimmunol.1000126
• 发表时间: 2010-06-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Sayed, Blayne A.;Christy, Alison L.;Brown, Melissa A.
• 通讯作者: Brown, Melissa A.

New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action?

• DOI: 10.1016/j.bbadis.2011.02.009
• 发表时间: 2012-01
• 期刊: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
• 影响因子: 6.2
• 作者: Walker, Margaret E.;Hatfield, Julianne K.;Brown, Melissa A.
• 通讯作者: Brown, Melissa A.