Integrating EEG/MEG and fMRI: 99-M-0172

脑磁图数据记录和信号处理方法的发展非常成功。对工作记忆任务和听觉处理任务的研究表明，有能力定位大脑的激活，并解决相位与紧张性活动的问题。我们还开始调查表型指标，这些指标将适用于许多相关研究，特别是兄弟姐妹项目。我们现在正在研究通过兄弟会项目录取的几乎所有科目。 认知激活期间的脑磁图记录已经显示出以与功能磁共振非常相似的方式进行定位的能力。具体地说，已经发现皮层水平的β去同步化与大胆的激活结果一致。然而，脑磁图/脑电允许使用其他成像技术所不能提供的时间信息。利用先进的信号处理技术，已经证实了大脑各区域之间的相位关系。到目前为止，我们的结果表明，大脑结构和功能的测量是寻找易感基因的强大工具。 精神分裂症患者在工作记忆任务中的激活程度，特别是以β去同步化为指标的额叶区域，与健康的兄弟姐妹和正常对照志愿者相比存在差异。对这种激活的进一步研究揭示了与研究得很好的COMT标记的基因型的交互作用。

Development of MEG data recording and signal processing methods has been very successful. Studies of working memory tasks and auditory processing tasks have shown the ability to localize brain activation and to address issues of phasic versus tonic activity. We have also begun to investigate phenotype measures that will be applicable in many related studies and specifically the sibling project. We are now studying almost all subjects admitted thru the sibling project. MEG recording during cognitive activation has shown the ability to localize in very comparable fashion to fMRI. Specifically beta desynchronization at the cortical level has been found to agree with BOLD activation results. However, the MEG/EEG allows for temporal information not possible with other imaging techniques. Phasic relationships across brain areas have been demonstrated using advanced signal processing techniques. Our results to date show that measures of brain structure and function represent powerful tools to find susceptibility genes. Diffrerences in the degree of activation especially in frontal regions as indexed by beta desynchronization during a working memory task have been found between patients with schizophrenia compared to well siblings and normal control volunteers. Further investigation of this activation has revealed an interaction with genotype for the well studied COMT marker.