Spinal And Peripheral Mechanisms Of Human Motor Control

人体运动控制的脊柱和外周机制

• 批准号: 7735280
• 负责人: Mary Kay Floeter
• 金额: $ 72.53万
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7735280
• 关键词: Amyotrophic Lateral Sclerosis; Base of the Brain; Communities; Complex; DNA; Disease; Electroencephalography; Functional disorder; Goals; Human; Image; Impairment; Interneurons; Magnetic Resonance Imaging; Motor; Motor Cortex; Motor Neuron Disease; Motor Neurons; Movement; Muscle; Neurons; Neuropsychological Tests; Numbers; Patients; Peripheral; Physiological; Population; Primary Lateral Sclerosis; Protocols documentation; Reporting; Research; Sampling; Signal Transduction; Spastic Paraplegia; Spinal; Work; brain computer interface; motor control; repository

Over the past several years, our research has focused on physiological changes in cortical and spinal motor circuits in patients with primary lateral sclerosis (PLS). In collaborative studies with Dr. Ou Bai, we identified oscillatory EEG signals that preceded movement in PLS patients in whom the slow DC potentials generated by cortical neurons were diminished. In FY08, we report that single-trial changes in these oscillatory signals with imagined movement can provide a control signal for an EEG-based brain-computer interface in a small number of PLS patients. This work is being extended to amyotrophic lateral sclerosis (ALS) patients in the coming year. A second line of study is aimed at assessing the extent of (non-motor) frontal cortical dysfunction in PLS patients, and to compare them to patients with ALS. This 3-year protocol includes neuropsychological tests, psychiatric assessment, and quantitative MRI imaging, and is in its second year. Lastly, recognizing that PLS is likely to be complex disorder, we are collecting samples from PLS patients for the NINDS DNA repository for motor neuron diseases at Coriell, so that this rare population will be accessible to the general scientific community for further studies.

在过去的几年里，我们的研究重点是原发性侧索硬化症（PLS）患者皮质和脊髓运动回路的生理变化。在与白欧博士的合作研究中，我们发现了 PLS 患者运动前的振荡脑电图信号，这些患者皮质神经元产生的慢直流电位减弱。在 2008 财年，我们报告称，这些振荡信号与想象运动的单次试验变化可以为少数 PLS 患者的基于脑电图的脑机接口提供控制信号。这项工作将于明年扩展到肌萎缩侧索硬化症（ALS）患者。第二项研究旨在评估 PLS 患者（非运动）额叶皮质功能障碍的程度，并将其与 ALS 患者进行比较。这个为期 3 年的协议包括神经心理学测试、精神病学评估和定量 MRI 成像，目前已是第二年。最后，认识到 PLS 可能是一种复杂的疾病，我们正在为 Coriell 的 NINDS 运动神经元疾病 DNA 存储库收集 PLS 患者的样本，以便广大科学界可以利用这一罕见人群进行进一步研究。

项目成果

Physiology of the motor cortex in polio survivors.

脊髓灰质炎幸存者运动皮层的生理学。

• DOI: 10.1002/mus.20913
• 发表时间: 2008
• 期刊: Muscle & nerve
• 影响因子: 3.4
• 作者: Lupu,VitalieD;Danielian,Laura;Johnsen,JacquelineA;Vasconcelos,OlavoM;Prokhorenko,OlgaA;Jabbari,Bahman;Campbell,WilliamW;Floeter,MaryKay
• 通讯作者: Floeter,MaryKay

Bilateral painful hand-moving fingers: electrophysiological assessment of the central nervous system oscillator.

双侧移动手指疼痛：中枢神经系统振荡器的电生理学评估。

• DOI: 10.1002/1531-8257(200011)15:6<1259::aid-mds1032>3.0.co;2-5
• 发表时间: 2000
• 期刊: Movement disorders : official journal of the Movement Disorder Society
• 作者: Jabbari,B;Molloy,FM;Erickson,M;Floeter,MK
• 通讯作者: Floeter,MK

Patterned sensory stimulation induces plasticity in reciprocal ia inhibition in humans.

模式化的感觉刺激在人类的相互抑制中诱导可塑性。

• DOI: 10.1523/jneurosci.23-06-02014.2003
• 发表时间: 2003
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Perez,MonicaA;Field-Fote,EdelleC;Floeter,MaryKay
• 通讯作者: Floeter,MaryKay

Decreased thickness of primary motor cortex in primary lateral sclerosis.

原发性侧索硬化症的初级运动皮层厚度减少。

• 发表时间: 2007
• 期刊: AJNR. American journal of neuroradiology
• 作者: Butman,JA;Floeter,MK
• 通讯作者: Floeter,MK