T Cell responses in Liver Gene therapy

肝脏基因治疗中的 T 细胞反应

• 批准号: 7595327
• 负责人: James M Wilson
• 金额: $ 40.86万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7595327
• 关键词: Abetalipoproteinemia; Address; Adenoviruses; Adoptive Transfer; Affinity; Animal Model; Animals; Antigens; Capsid; Cardiovascular Diseases; Cell Line; Cells; Clinical; Clinical Research; Clinical Trials; Complementary DNA; Cross Presentation; Cytotoxic T-Lymphocytes; DNA Viruses; Data Aggregation; Dependovirus; Disease; Engineering; Engraftment; Epitopes; Evaluation; Familial Hypercholesterolemia; Family; Gagging; Gene Transfer; Generations; HIV; HIV-1; Health Sciences; Hemophilia A; Hepatocyte; Hepatotoxicity; Human; Human Resources; Immune; Immunization; Infection; Injection of therapeutic agent; Last Name; Liver; Low Density Lipoprotein Receptor; MHC Class I Genes; Macaca; Memory; Modeling; Mus; Names; Oregon; Pennsylvania; Population; Primates; Principal Investigator; Printing; Process; Proteins; Registries; Reporter Genes; Research; Research Project Grants; Role; Safety; Series; Stem cells; T memory cell; T-Cell Activation; T-Lymphocyte; T-Lymphocyte Epitopes; Technology; Time; Toxic effect; Transferase; Transgenes; Triglycerides; Universities; Wild Type Mouse; Xenograft procedure; adeno-associated viral vector; base; cellular engineering; gene therapy; human embryonic stem cell; liver xenograft; mature animal; mouse model; nonhuman primate; novel; pre-clinical; preclinical study; programs; reconstitution; research study; response; vector

Use continuation pages as neededto provide the required information in the format shown below. Start with Program Director(s)/Principal Investigator(s). List all other senior/key personnel in alphabetical order, last name first. Name eRA Commons User Name Organization Role on Project Wilson, James M. WILSONJM University of Pennsylvania PI Wang, Lili LILIWANG University of Pennsylvania Co-Pi OTHER SIGNIFICANT CONTRIBUTORS Name Organization Role on Project Riley, James University of Pennsylvania Collaborator Grompe, Marcus Oregon Health & Science University Collaborator Human Embryonic Stem Cells ^ No Q Yes If the proposedproject Involves humanembryonic stem cells, list below the registration number of the specificcell line(s) from the following list: http://stemcells.nih.gov/research/reaistrv/. Usecontinuation pages as needed. If a specific line cannot be referenced at this time, include a statement that one from the Registry will be used. Cell Line PHS 398 (Rev. 11/07) Page t,1 Form Page 2-continued Number the following pages consecutivelythroughout the application. Do not use suffixes such as 4a, 4b, PROJECT I Program Director/Principal Investigator (Last, First, Middle): Wilson, James M. / WilSOH, James M. The name of the program director/principal investigator must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Description, Project/

根据需要使用延续页，以下列格式提供所需的信息。