Data management and analysis

核心B，数据管理和分析核心(DMAC)有两组主要职责，这可能 可视为具体目标：(A)数据管理和(B)数据分析。我们已经扩展了以下功能 核心B作为所有临床、遗传和表型数据的交换中心。以这种方式，核心B将 有效地成为跟踪所有数据及其来源的集中式小组。 核心可供其他核心和项目的首席调查员用于：(A)获取人力 标本，包括DMA(血液)和手术组织标本；(B)获得相关的临床， 与标本有关的人口统计和详细表型数据；(C)管理和检查 向核心B的数据库资源提供信息；(D)提供用于统计分析和 支持。这一核心结构将允许临床和基础科学研究的最佳协调 计划，通过提供单一的集中化资源。所有项目和Core C监控并选择哪些样本 和/或数据可供它们使用。项目将使用核心B来安排从以下任一地点获取样本 加州大学旧金山分校DMA银行或Core C外科组织银行。 数据分析包括生物统计数据分析、数据清理、质量保证、患者监护 征聘和保留，以及编写中期报告。最佳生物统计分析还包括 参与实验设计问题。核心B还将协助编写手稿和 演示文稿。

Core B, the Data Management and Analysis Core (DMAC) has two primary sets of responsibilities, which may be viewed as specific aims: (a) data management, and (b) data analysis. We have extended the capabilities of Core B to act as a clearinghouse for all clinical, genetic and phenotypic data. In this fashion, Core B will effectively be the centralized group that tracks all data and its sources. The Core is available to the Principal Investigators of the other Cores and Projects for: (a) obtaining human specimens, including both DMA (blood) and surgical tissue specimens; (b) obtaining associated clinical, demographic and detailed phenotypic data associated with specimens; (c) managing and checking the flow of information into the database resources of Core B; and (d) providing datasets for statistical analysis and support. This core structure will allow for optimal coordination of the clinical and basic science research programs by providing a single centralized resource. All projects and Core C monitor and select what samples and/or data may be available for their use. Projects will use Core B to arrange obtaining specimens from either the UCSF DMA bank or the Core C surgical tissue bank. Data analysis includes biostatistical data analysis, data cleaning, quality assurance, monitoring patient recruitment and retention, and preparation of interim reports. Optimal biostatistical analysis also includes involvement in experimental design issues. Core B will also assist in preparation of manuscripts and presentations.