High Energy Density Film Capacitors for Compact Implantable Cardioverter Defibril

用于紧凑型植入式心脏复律除颤器的高能量密度薄膜电容器

• 批准号: 7885392
• 负责人: Shihai Zhang
• 金额: $ 37.38万
• 依托单位: STRATEGIC POLYMER SCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7885392
• 关键词: Acquired Immunodeficiency Syndrome; Advanced Development; Aluminum; American; Anti-Arrhythmia Agents; Arrhythmia; Charge; Chest; Clinical Trials; Development; Devices; Electric Countershock; Electrodes; Electronics; Figs - dietary; Film; Goals; Heart; Heart Arrest; Heart failure; Hour; Implant; Implantable Defibrillators; Life; Liquid substance; Malignant neoplasm of lung; Medical; Miniaturization; Monitor; Operative Surgical Procedures; Patients; Phase; Physiologic pulse; Polymers; Process; Prunella vulgaris; Science; Signal Transduction; Small Business Innovation Research Grant; Speed; Tantalum; Technology; Time; Translating; Universities; Weight; base; cost; effective therapy; energy density; heart rhythm; improved; in vitro testing; innovation; malignant breast neoplasm; mortality; programs; prototype; public health relevance; sensor; sudden cardiac death; voltage

DESCRIPTION (provided by applicant): More than 1000 American die every single day due to sudden cardiac arrest (SCA), which claims more lives than breast cancer, AIDS, and lung cancer combined.1 Implantable Cardioverter Defibrillators (ICD) can provide 24-hour monitoring of heart rhythm and deliver immediate effective treatment, thus can reduce overall mortality by 23% and provide 2.5 more years of life for a patient. However, the size, cost, and reliability of current ICD limit its acceptance by the patients. As a key component, the capacitor occupies more than 1/3 of the ICD volume and delivers the necessary defibrillation energy to the heart. In the Phase I program, Strategic Polymer Sciences, Inc (SPS) has demonstrated that ultrahigh energy density (27 J/cm3) can be achieved in SPS breakthrough capacitor films, which is much higher than the current ICD capacitors (4-6 J/cm3) and ten times higher than other polymer film capacitors (< 2 J/cm3) (Science 313:334 (2006), "A dielectric polymer with high electric energy density and fast discharge speed"). In addition, SPS dielectric polymers have self-healing feature, do not contain any liquid, do not require regular reforming, thus can improve the reliability of the ICD and extend the battery life. In the Phase II program, SPS will develop prototype ICD capacitors for in vitro test. PUBLIC HEALTH RELEVANCE: The development of advanced high energy density capacitors based on innovative SPS technology can significantly reduce the size/weight and cost of Implantable Cardioverter Defibrillators (ICD). This will enable the wide accessibility and acceptance of ICD to millions of Americans threaded by sudden cardiac arrest.

描述（由申请人提供）：每天有超过1000名美国人死于心脏骤停（SCA），其夺去的生命比乳腺癌、艾滋病和肺癌加起来还要多植入式心律转复除颤器（ICD）可以提供24小时心律监测并提供即时有效的治疗，因此可以将总死亡率降低23%，并为患者提供2.5年以上的生命。然而，目前ICD的尺寸、成本和可靠性限制了其被患者接受。电容器作为关键部件，占据ICD容积的1/3以上，向心脏输送必要的除颤能量。在第一阶段项目中，Strategic Polymer Sciences, Inc （SPS）已经证明，SPS突破性电容器薄膜可以实现超高能量密度（27 J/cm3），远远高于目前的ICD电容器（4-6 J/cm3），比其他聚合物薄膜电容器（< 2 J/cm3）高出十倍（Science 313:334(2006)，“具有高电能密度和快速放电速度的介电聚合物”）。此外，SPS介电聚合物具有自愈特性，不含任何液体，不需要定期重整，因此可以提高ICD的可靠性，延长电池寿命。在第二阶段计划中，SPS将开发用于体外测试的ICD电容器原型。公共卫生相关性：基于创新SPS技术的先进高能量密度电容器的开发可以显着减少植入式心律转复除颤器（ICD）的尺寸/重量和成本。这将使数以百万计因心脏骤停而困扰的美国人能够广泛地获得和接受ICD。