High Energy Density Film Capacitors for Compact Implantable Cardioverter Defibril

描述(申请人提供)：每天有1000多名美国人死于心脏骤停(SCA)，这比乳腺癌、艾滋病和肺癌夺走的生命加起来还多。1植入式心脏复律除颤器(ICD)可以24小时监测心率并提供即时有效的治疗，从而可以将总死亡率降低23%，并为患者多提供2.5年的生命。然而，目前ICD的大小、成本和可靠性限制了它被患者接受。作为一个关键部件，电容器占据了ICD体积的三分之一以上，并将必要的除颤能量传递给心脏。在第一阶段计划中，战略聚合物科学公司(SPS)已经证明，在SPS击穿电容器薄膜中可以实现超高的能量密度(27J/cm3)，这远远高于目前的ICD电容器(4-6J/cm3)，是其他聚合物薄膜电容器(&lt；2J/cm3)的十倍(Science 313：334(2006)，“一种具有高电能密度和快速放电速度的介电聚合物”)。此外，SPS介电聚合物具有自愈功能，不含任何液体，不需要定期重整，从而可以提高ICD的可靠性，延长电池寿命。在第二阶段计划中，SPS将开发用于体外测试的ICD电容器原型。公共卫生相关性：基于创新的SPS技术开发先进的高能量密度电容器可以显著降低植入式心脏复律除颤器(ICD)的尺寸/重量和成本。这将使数百万因心脏骤停而紧张的美国人能够广泛获得和接受ICD。

DESCRIPTION (provided by applicant): More than 1000 American die every single day due to sudden cardiac arrest (SCA), which claims more lives than breast cancer, AIDS, and lung cancer combined.1 Implantable Cardioverter Defibrillators (ICD) can provide 24-hour monitoring of heart rhythm and deliver immediate effective treatment, thus can reduce overall mortality by 23% and provide 2.5 more years of life for a patient. However, the size, cost, and reliability of current ICD limit its acceptance by the patients. As a key component, the capacitor occupies more than 1/3 of the ICD volume and delivers the necessary defibrillation energy to the heart. In the Phase I program, Strategic Polymer Sciences, Inc (SPS) has demonstrated that ultrahigh energy density (27 J/cm3) can be achieved in SPS breakthrough capacitor films, which is much higher than the current ICD capacitors (4-6 J/cm3) and ten times higher than other polymer film capacitors (< 2 J/cm3) (Science 313:334 (2006), "A dielectric polymer with high electric energy density and fast discharge speed"). In addition, SPS dielectric polymers have self-healing feature, do not contain any liquid, do not require regular reforming, thus can improve the reliability of the ICD and extend the battery life. In the Phase II program, SPS will develop prototype ICD capacitors for in vitro test. PUBLIC HEALTH RELEVANCE: The development of advanced high energy density capacitors based on innovative SPS technology can significantly reduce the size/weight and cost of Implantable Cardioverter Defibrillators (ICD). This will enable the wide accessibility and acceptance of ICD to millions of Americans threaded by sudden cardiac arrest.